Modere Axis TreBiotic Review – Is This Gut Supplement Worthwhile?

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

modere axis trebiotic review

The gut microbiome is an insanely hot topic today in the wellness world. And you can bet your money that supplement companies have attempted to cash in on this popularity. Of course, with so many gut health supplements out there, it’s hard to figure out which ones are actually effective. That’s why we’re here to help!

We’re going to take a look at one specific gut health supplement called Modere Axis TreBiotic. Is this gut microbiome supplement worth using? Does it have the right ingredients? Provide the benefits you want? In this Modere Axis TreBiotic review, we’ll answer all of those questions and more so you can find out if this supplement can truly enhance your gut microbiome and overall health. 

Ready? Let’s dive in!

modere axis trebiotic

About Modere Axis TreBiotic

Modere Axis TreBiotic is a gut microbiome supplement from Modere, a well-known health and wellness company. Modere aims to make clean supplements and lifestyle products based on research and science. This, of course, includes Modere Axis TreBiotic as well as their many other supplements such as Modere Trim, Modere Go, and Modere Life.

Modere Axis TreBiotic is designed to enhance the health of your gut and other areas connected to it. The “tre” refers to the 3-in-1 Microbiome Matrix technology, which is designed to support the gut with three key ingredients: prebiotics, probiotics, and postbiotics. 

Plus, they use a unique beadlet delivery system and acid-resistant strains to make sure the product actually gets where it needs to go. Thus, Modere Axis TreBiotic is supposed to be an optimal supplement not only for the gut microbiome, but for the rest of your body as well. 

Modere Axis TreBiotic Benefits

There are a number of advertised benefits from Modere Axis TreBiotic, such as:

  • Improved gastrointestinal health
  • Supported gut barrier integrity
  • Enhanced microbiome diversity
  • Optimized micronutrient synthesis
  • Immune support
  • Better brain and cognitive function
  • Enhanced overall well-being and energy

modere axis trebiotic improved gut health

Gut Health 

The first three benefits, gastrointestinal health, gut barrier integrity, and microbiome diversity, are all due to the specific ingredients in their Microbiome Matrix. The prebiotics, probiotics, and other substances are designed to promote increased growth and health of gut bacteria, while also supporting gut barrier integrity and contributing to overall gut function. 

Micronutrient Synthesis

Modere Axis TreBiotic is also advertised to improve micronutrient synthesis, largely due to enhanced microbiota health and function. 

Immune Support

The gut is connected to the immune system, so it’s no surprise here that this product is also designed to support immune health and function via the gut microbiome. 

Brain and Cognitive Function

Modere Axis TreBiotic is also designed to support brain health and cognitive function, again due to the connections between the gut and brain, often referred to as the gut-brain axis. 

Overall Well-Being and Energy

The makers of Modere Axis TreBiotic claim that the gut microbiome is the “master switch” to wellness, and thus increasing gut health ultimately can enhance energy levels and overall well-being. 

These are some pretty normal claims for a gut health supplement. But will Modere Axis TreBiotic stand out from the rest? Or will it even work at all? Read on to find out!

Modere Axis TreBiotic Ingredients

Modere Axis TreBiotic has just a few ingredients, all included in their Microbiome Matrix Proprietary Blend. Here’s what’s in each serving, which is one scoop: 

modere axis trebiotic supplement facts


Up first is galactooligosaccharides, which is a type of prebiotic. These non-digestible carbohydrates pass through the upper gastrointestinal (GI) tract and reach the colon, where they can promote the growth of beneficial bacteria and thus increase gut health. In turn, galactoologisoaccharides, as evidenced by research, can improve irritable bowel syndrome (IBS), digestion, micronutrient absorption, immune health, cholesterol and fat metabolism, and even mental health (e.g., reductions in anxiety). 


Modere Axis TreBiotic also has EpiCor, which is a whole food fermentate made from baker’s yeast. It acts as a postbiotic, which is a metabolite resulting from probiotics, and that can benefit gut health. rEsearch on EpiCor shows that it can reduce digestive distress, decrease pathogens, increase probiotics, and improve bowel function and overall gut health. 

500mg per day is recommended. 

Probiotic Complex

Another main ingredient included in this formula is the Neuroflora probiotic complex, which includes lactobacillus plantarum DR7, pediococcus acidilactici, and lactobacillus brevus. Probiotics are the good bacteria themselves, so taking in probiotics is a direct way to increase the number of healthy gut bacteria. And probiotic supplementation with these specific strains is typically able to improve overall GI health, immune health, mood, cognitive function, and nutrient absorption. 

Saffron Stigma Extract

The last ingredient is saffron stigma extract. Saffron has many different benefits, particularly related to its antioxidant and anti-inflammatory effects. And research shows that it can improve mood and cognitive function. 

Does Modere Axis TreBiotic Work?

Based on the evidence, Modere Axis TreBiotic should be a pretty effective gut microbiome supplement. It contains prebiotics, probiotics, and postbiotics, all of which can support gut health and other aspects of health in different ways. 

modere axis trebiotic and two other products

For example, the research has shown that these ingredients should improve digestion, nutrient absorption, immune health, fat, and cholesterol metabolism, mood, and overall GI function, thus reducing the risk for IBS, bloating, and other GI problems. 

Plus, there’s research on the specific forms of the ingredients used in Modere Axis TreBiotic, such as EpiCor, and lactobacillus plantarum DR7. Another benefit of this product is that the strains used are able to resist stomach acid and reach the colon, so they can exert their benefits in the place that matters most.

One downfall is the fact that the ingredients are in a proprietary blend weighing only a little over 1 gram. As such, the dosages are probably too low, especially since EpiCor itself should be around 500mg and galatooligosaccharides should be at least 2.5g. This definitely marks down the potential effectiveness, but it still should be a pretty solid product. 

Claims vs. Reality

So, overall, Modere Axis TreBiotic should do what it says, especially since there aren’t any specific claims made, such as like increasing digestion by 300 percent or something. What you should get out of this product is mild to moderate improvements in gut health and possible improvements in immune health, mood, cognitive function, and other related areas. 

But don’t expect this product to work instantly, either. Improvements in gut health typically take at least a few weeks and are most noticeable after a couple of months. The key is to be consistent since it takes a while to build up the gut microbiome to a once-again healthy level. 

Who is Modere Axis TreBiotic Best For?

Modere Axis TreBiotic is best for anyone dealing with various GI issues and poor health in general. While you could always get a prebiotic supplement, like Performance Lab Prebiotic, or a probiotic supplement, like Biohm Probiotic, having the combination of prebiotics, probiotics, and postbiotics all in one is a nice benefit of Modere Axis TreBiotic.

If you have bloating, indigestion, nausea, flatulence, and coinciding issues such as low mood, energy, or immunity, then Modere Axis TreBiotic could be a great supplement to implement alongside a healthy diet and lifestyle. 

modere axis trebiotic stomach discomfort

Is Modere Axis TerBiotic Safe?

Modere Axis TreBiotic is generally a safe product. Here are some possible side effects:

  • Bloating, stomach discomfort, flatulence, and other GI symptoms (usually reside after a week or so as the GI system adjusts)

Modere Axis TreBiotic is gluten-free, sugar-free, non-GMO, vegetarian, and keto-friendly. 

Also, it is made in the USA in a NSF GMP-certified facility. 

Where to Buy Modere Axis TreBiotic

You can buy Modere Axis TreBiotic on the Modere website at this product link.

modere axis trebiotic website

Each container has 30 servings. The regular price of Modere Axis TreBiotic is $74.99. Or, you can choose the Subscribe and Save option, which lowers the price to between $63.74 and $71.24 (depending on the total number of Modere products you buy). 

Regardless, this is an expensive product, since you’ll be paying over two dollars per serving no matter what, up to $2.50/serving for the regular price. Most gut health supplements are typically under $2/serving, but it’s still worth looking into because of its quality potential. 

Overall Rating:
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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.

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