Last Updated: Aug 19, 2020

Bio Complete 3 Review – Is This Gundry MD Gut Health Supplement Worth It?

Research-Based Trusted Source

If you know your pre and probiotics but are unfamiliar with postbiotics, we think you’ll find this article very informative. Who better to introduce us to this new “biotic” than Dr. Steven Gundry of Gundry MD. After a long and distinguished career as one of the world’s pre-eminent experts in heart surgery, Dr. Gundry left his position as Head of Cardiothoracic Surgery at California’s Loma Linda University Medical Center in 2002 and founded The Center for Restorative Medicine. He has spent the ensuing years studying the human microbiome, writing several New York Times bestsellers, and developing his principles of “Holobiotics.” His Center, “Holobiotics,” and his published works focus on lifestyle, nutrition and diet, and their relationship to the human microbiome.

In this review, we will explore Gundry MD’s Bio Complete 3 – the product that introduces postbiotics. We’ll go over its ingredients, discuss its efficacy, and provide our assessment of whether or not it is worth the purchase. Let’s dive in with this Bio Complete 3 review.

Gundry MD Bio Complete 3

Gundry MD Supplements

Dr. Gundry has spent nearly twenty years focusing on the microbiome, the trillions of tiny microbes that live everywhere in, on, and around your body, lifestyle, nutrition, and diet. In addition to his published works, his company has developed an extensive line of supplements, skin, haircare, and food products.

Dr. Steven Gundry

Dr. Gundry has been at the forefront of gut health, its role in immune health, and products developed for digestive health:

  • Total Restore – to promote a strong, healthy gut lining
  • Prebiothrive – prebiotics
  • GI Renew – digestive enhancement
  • Metabolic Advanced – metabolic support
  • Lectin Shield – to eliminate toxic proteins
  • Primal Plants – improves digestion
  • 24 Strain Probiotic – probiotics
  • Power Blues – contains pre and probiotics
  • Gundry’s Bio Complete 3 – pre, pro, and postbiotics

The products, website, and writings all support the company’s mission statement, “To dramatically improve human health, happiness, and longevity through a unique vision of diet and nutrition.”

Bio Complete 3 And Gundry MD Supplements

Dr. Gundry’s “Holobiotics” Philosophy

To know “Holobiotics,” people must first understand that different microbes dominate their bodies. Some of these microbes are good, while others are bad. Unfortunately, most people choose a diet and lifestyle that kills off their good bacteria and increases the growth and multiplication of harmful microbes. This loss of the proper microbe ratio eventually throws off the balance and wellness of your whole body.

“Holobiotics” is the phrase Dr. Gundry created for the diet and lifestyle choices people must make to support their good microbes and bring the ratio back into balance to improve their health.

Biotics, Pre, Pro, And Postbiotics

The National Center for Biotechnology Information tells us that the term “biotics refers to nutritional strategies that can direct gut microbiota towards a more favorable state for host health.” The concept is that prebiotics, probiotics, and synbiotics (food ingredients or dietary supplements, combining probiotics and prebiotics), can change the gut microbiota and its activity to affect the immune response positively. You will remember that the beneficial bacteria in our gut represents some 70% – 80% of our immune cells, which protect us against colds, pathogens, viruses, and other “bugs.”

If you want to stay healthy, taking care of your gut health is paramount. When your immune system is compromised, you are at an increased risk for autoimmune diseases, colds, cases of flu, allergies, and a myriad of other conditions.

  • Prebiotics are microorganisms that support the healthy balance of good bacteria, the probiotics, in your gut.
  • Probiotics are living organisms, the healthy bacteria that protect against digestive issues, as Dr. Gundry likes to say, your gut buddies.
  • Synbiotics refers to a mixture of prebiotics and probiotics that improve the survival rate and activity of beneficial microorganisms in the gut.

NCBI tells us that the newest member of the biotics family, “postbiotics, refers to bioactive compounds produced by food-grade microorganisms during a fermentation process. They include microbial cells, cell constituents, and metabolites designed to help promote health.”

Postbiotics is a rather new term, and although we understand the definition of pre and probiotics, postbiotics are still a bit vague and include a myriad of compounds including:

  • Metabolites
  • Short-chain fatty acids (SCFAs)
  • Microbial cell fractions
  • Functional proteins
  • Extracellular polysaccharides (EPS)
  • Cell lysates

NCBI further proposes that the use of postbiotics in healthy individuals can improve overall health and relieve symptoms in a range of diseases. Perhaps Dr. Gundry is on to something, again, that will improve the microbiome.

What Is Bio Complete 3?

Bio Complete 3 is a dietary supplement in vegetable capsule form, which includes three proprietary trademarked, all-natural ingredients, a prebiotic, probiotic, and postbiotic. Dr. Gundry refers to the formulation as his 3-Pronged Defense for gut health:

  1. Probiotics to provide an abundance of good gut bacteria
  2. Prebiotics providing fuel for the good bacteria
  3. Postbiotics to support the gut lining and to alleviate symptoms of “leaky gut”

The product is manufactured in the U.S. in a certified cGMP (current Good Manufacturing Practices) facility, and the formula is quality and purity tested at an independent, third-party lab. Bio Complete 3 is sugar-free, gluten-free, free of soy, dairy, lectins, and artificial sweeteners. Like all Gundry MD products, Bio Complete is supported by a ninety-day money-back guarantee. These are all best in class standards within the nutritional supplement industry.

Each bottle of Bio Complete 3 contains 120 capsules, a thirty-day supply.

Bio Complete 3 Bottle And Pills

Bio Complete 3 Ingredients

Bio Complete 3 has only three ingredients. Each ingredient is a trademarked or registered compound, owned by an ingredient manufacturer and licensed to Gundry MD.

Bio Complete 3 Supplement Facts

The first ingredient, CoreBiome™, Tributyrin, 1000 mg, is licensed to Gundry MD under an exclusive global distribution agreement with Compound Solutions. Compound Solutions is a respected nutraceutical ingredient manufacturer that provides unique, patented ingredients to the natural products industry. Another Compound Solution ingredient, TeaCrine®, is a staple in the pre-workout products of many of the largest brands in the space.

CoreBiome™ is an SCFA (Short-Chain Fatty Acid). There are three fatty acids, short-chain, medium-chain, and long-chains. People are most familiar with MCTs, medium-chain fatty acids due to the popularity of MCT (Medium Chain Triglycerides) Oils. Long-chain fatty acids are things such as avocados, olive oil, and fish and are healthy also.

Short-chain fatty acids (less than six carbon atoms) may be the most important of the three fatty acids for wellness and are arguably more essential to gut health than either pre or probiotics in promoting balance. SCFAs help create a healthy environment in your gut allowing healthy bacteria to thrive while preventing excess levels of harmful bacteria. Used in conjunction with pre and probiotics, postbiotics create a synbiotic relationship in gut health.

To quote Compound Solutions, “SCFAs such as CoreBiome™ are like a multivitamin for your gut.”

The second trademarked ingredient, Sunfiber® (200 mg) licensed from Taiyo International, Incorporated, is a prebiotic and soluble fiber. This ingredient, which qualifies as a dietary fiber under new FDA guidelines, delivers clinically substantiated health benefits:

  • Supports digestive health
  • Weight management
  • Reduces the glycemic index
  • Feeds beneficial gut bacteria

The third ingredient is ProDURA® 2 Billion CFUs, a registered trademark of UAS Laboratories. UAS Labs, located in Wausau, WI, positions themselves as the Probiotics Company® and prides themselves on their extensive work in clinical research and trials. ProDURA® a Bacillus coagulans probiotic, a unique strain of spore-forming bacteria that supports a healthy balance of beneficial to harmful bacteria in the gut.

Bio Complete 3 Pill Capsules

Overall, we are very favorably impressed with the well-researched, clinically supported, and patented ingredients in the Bio Complete 3 formulation.

Recommended Dosage Of Bio Complete 3

The company’s recommended dosage is two capsules twice per day, preferably before a meal. Dr. Gundry emphasizes taking Bio Complete 3 consistently for optimal gut health and relates he takes his product in the morning before breakfast and again before dinner for twenty-four-hour protection.

Bio Complete 3 Dosage

Bio Complete 3 Benefits

The most significant benefits of Bio Complete 3 are its support of a healthy gut lining, a robust immune system, and its promotion of a healthy balance of beneficial bacteria in the gut. Additional benefits include aiding in digestion, weight management, reduced cravings, providing improved energy, and addressing any stomach or bowel discomfort.

How Does Bio Complete 3 Perform – Claims Vs. Reality

Bio Complete 3 gets high marks for efficacy in reducing bloating and increased energy and vitality. The fiber performs its function, aiding in digestion, relieving abdominal distress, and regularity. There was no noticeable weight loss while using the product; however, we would still endorse this regimen for anyone with stomach issues.

Bio Complete 3 Supplement

Is Bio Complete 3 Safe?

Although there are no instances of serious adverse effects from Bio Complete 3, the combination of ingredients may cause some individuals issues such as bloating, gas, constipation, and thirst.

And, always consult your medical professional before starting any new dietary supplement.

Bio Complete 3 Pricing

Bio Complete 3 is available on the official Gundry MD website for $69.95 per bottle. You can use this link to get your first bottle for only $49.95.

Bio Complete 3 Gundry MD Website

Further discounts are available when you purchase multiple bottles at a time. You can get 3 bottles for $134.95 ($45/bottle) or 6 bottles for $254.70 ($42/bottle). You will also get free shipping when you purchase either the 3-pack or the 6-pack.

You can save an additional 10% off all packages by signing up for a subscription. Subscriptions can be canceled at any time, although we only recommend signing up for the subscription if you actually want recurring orders.

If you have never tried Gundry MD Bio Complete 3 before, we recommend starting with a single bottle so you can see how it works for you. If you are happy with the product, you can save money by stocking up in advance.

Like all of Gundry MD’s products, Bio Complete 3 is backed by a 90-day money-back guarantee.

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In Summary: Bio Complete 3

We are favorably impressed with Gundry MD and Bio Complete 3. They are transparent in their ownership, marketing, labeling, and packaging. They use an independent third-party facility to test all products and stand behind their product with a 90-day, money-back guarantee. We applaud the formulation with its three patented, clinically tested ingredients, and no proprietary blends. We give Bio Complete 3 excellent grades for efficacy, supported by a plethora of favorable reviews on the company website, which were in line with our findings.

Bio Complete 3 Review
  • Efficacy
  • Value


Bio Complete 3 is a dietary supplement manufactured and founded by Dr. Gundry, owner of Gundry MD. This supplement contains a unique 3-pronged blend of probiotics, prebiotics, and postbiotics that aim to work together to give your gut a major boost. Bio Complete 3 claims it can help you achieve a slimmer waistline, smoother digestion, reduced cravings for unhealthy “junk foods”, and help restore your energy levels. Learn more about this pre, pro, and postbiotic supplement in our review of Bio Complete 3.

Disclosure: Some of the links in our articles are from our advertisers. Learn more about how we make money.

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