Bio Complete 3 Review – Is This Gundry MD Gut Health Supplement Worth It?

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By Thomas Youngerman

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Bio Complete 3 Review

Keeping our gut happy and healthy is an important part of our overall well-being. But having good gut health is easier said than done, and many of us are missing out on key things our bodies and guts need to not only survive but also thrive. 

That’s where Bio Complete 3 by Gundry MD claims to come in to help fill the gaps. This supplement is unique in that it not only includes prebiotics and probiotics but also postbiotics.

What are postbiotics? And, more importantly, is Bio Complete 3 a worthy option for your gut health? Let’s take a closer look at this supplement and all things gut health so you can make the final decision. We’ll discuss its ingredients, dosages, benefits, and more. Without further ado, let’s get started with this Bio Complete 3 review!

Bio Complete 3 Review: Key Facts

BenefitsGut Health, Weight Loss, Energy Levels
IngredientsTributyrin, Sunfiber, Bacillus Coagulans, and more
DiscountsUp to 40% Off
CompanyGundry MD

About Gundry MD

Indeed, who better to introduce us to this new “biotic” than Dr. Steven Gundry of Gundry MD?

After a distinguished career as one of the world’s experts in heart surgery, Dr. Gundry left his position as Head of Cardiothoracic Surgery at California’s Loma Linda University Medical Center in 2002. He then founded The Center for Restorative Medicine.

Since then, he has spent the ensuing years studying the human microbiome developing his principles of “Holobiotics.” 

Gundry MD Bio Complete 3

Gundry MD Supplements

Dr. Gundry has spent nearly twenty years focusing on the microbiome, the trillions of tiny microbes that live everywhere in, on, and around your body.

In addition to his published works, his company has developed an extensive line of supplements, skin, haircare, and food products.

Dr. Steven Gundry

Dr. Gundry has been at the forefront of gut health, its role in immune health, and in developing products for digestive health. Here are just a few of the popular products.

  • Total Restore – promotes a strong, healthy gut lining and prevent the leaky gut syndrome
  • Prebiothrive – prebiotics to regulate bowel movements, treat inflammatory bowel disease, and improve gut health
  • GI Renew – helps with digestive enhancement and reduction of stomach pain
  • Metabolic Advanced – provides metabolic support for improved energy levels, support digestion, and work out immune responses
  • Lectin Shield – eliminates toxic proteins
  • Primal Plants – improves digestion
  • 24 Strain Probiotic – a probiotic supplement
  • Power Blues – contains pre and probiotic strains
  • Gundry’s Bio Complete 3 – contains pre, pro, and postbiotics

The products, website, and writings all support the company’s mission statement, “To dramatically improve human health, happiness, and longevity through a unique vision of diet and nutrition.”


“Holobiotics” Philosophy

Before we get to the review of Bio Complete 3, it can be helpful to understand the philosophy behind the product. 

To know “Holobiotics,” people must first understand that different microbes dominate their bodies. Some of these microbes are good, while others are bad.

Unfortunately, most people choose a diet and lifestyle that kills off their good bacteria and increases the growth and multiplication of harmful microbes.

This loss of the proper microbe ratio eventually throws off the balance and wellness of your whole body. Some signs of this happening, include irritable bowel syndrome, weak immune system, and skin or stomach issues.

“Holobiotics” is the phrase Dr. Gundry created for the diet and lifestyle choices people must make to support their good microbes. Eventually, bringing the ratio back into balance and improving their health.

Prebiotics, Probiotics, and Postbiotics

The National Center for Biotechnology Information tells us that the term “biotics refers to nutritional strategies that can direct gut microbiota towards a more favorable state for host health.”

The concept is that prebiotics, probiotics, and synbiotics (food ingredients or dietary supplements, combining probiotics and prebiotics), can change the gut microbiota and its activity to affect the immune response positively.

You will remember that the beneficial bacteria in our gut represents some 70% – 80% of our immune cells, which protect us against colds, pathogens, viruses, and other “bugs.”

If you want to stay healthy, taking care of your gut health is paramount. When your immune system is compromised, you are at an increased risk for an autoimmune disease, colds, cases of flu, allergies, and a myriad of other conditions.

  • Prebiotics are microorganisms that support the healthy balance of good bacteria in your gut.
  • Probiotics are living organisms, the healthy gut bacteria that protect against digestive issues. As Dr. Gundry likes to say, these are your gut buddies.
  • Synbiotics refer to a mixture of prebiotics and probiotics that improve the survival rate and activity of beneficial microorganisms in the gut.

NCBI tells us that the newest member of the biotics family, postbiotics, refers to

“bioactive compounds produced by food-grade microorganisms during a fermentation process. They include microbial cells, cell constituents, and metabolites designed to help promote health.”

Postbiotics is a rather new term and still a bit vague. They include a myriad of compounds including:

  • Metabolites
  • Short-chain fatty acids (SCFAs)
  • Microbial cell fractions
  • Functional proteins
  • Extracellular polysaccharides (EPS)
  • Cell lysates

What Is Bio Complete 3?

Now that we’ve covered the holobiotics philosophy it’s time to discuss Bio Complete 3 and how it can improve your health.

Bio Complete 3 is a dietary supplement in vegetable capsule form. It also includes three proprietary trademarked, all-natural ingredients: prebiotic, probiotic, and postbiotic.

  1. Probiotics to provide an abundance of good gut bacteria
  2. Prebiotics to fuel the good bacteria
  3. Postbiotics to support the gut lining and to alleviate symptoms of “leaky gut”

The product is manufactured in the U.S. in a certified cGMP (current Good Manufacturing Practices) facility. The formula is quality and purity tested at an independent, third-party lab as well.

Bio Complete 3 is sugar-free, gluten-free, free of soy, dairy, lectins, and artificial sweeteners.

Each bottle of Bio Complete 3 contains 120 capsules, a thirty-day supply.

Bio Complete 3 Bottle And Pills

Bio Complete 3 Ingredients

As noted, Bio Complete 3 only has three ingredients. Each ingredient is a trademarked or registered compound, owned by an ingredient manufacturer and licensed to Gundry MD.

Bio Complete 3 Supplement Facts


The first ingredient is CoreBiome™, which consists of 1000 mg Tributyrin. This ingredient is also licensed to Gundry MD under an exclusive global distribution agreement with a company called Compound Solutions.

As a matter of fact, Compound Solutions is a respected nutraceutical ingredient manufacturer that provides unique, patented ingredients to the natural products industry.

CoreBiome™ is in fact a short-chain fatty acid (SCFA), one of three other fatty acids.

People are most familiar with MCTs, medium-chain fatty acids, due to the popularity of MCT oils. Long-chain fatty acids are present in foods such as avocados, olive oil, and fish and are healthy also.

Nonetheless, short-chain fatty acids may be the most important of the three fatty acids for wellness. They are arguably more essential to gut health than either pre or probiotics when promoting balance.

SCFAs help create a healthy environment in your gut allowing healthy bacteria to thrive. They also prevent excessive levels of harmful bacteria. At the end, when you use them in conjunction with pre and probiotics, postbiotics create a synbiotic relationship in gut health.

To quote Compound Solutions, “SCFAs such as CoreBiome™ are like a multivitamin for your gut.”


The second trademarked ingredient is licensed from Taiyo International Inc. It is a prebiotic and soluble fiber.

Moreover, this ingredient qualifies as a dietary fiber under new FDA guidelines, and delivers clinically substantiated health benefits:

  • Supports digestive health
  • Weight management and weight loss
  • Reduces the glycemic index
  • Feeds beneficial gut bacteria


Finally, the third ingredient is ProDURA® 2 Billion CFUs, which is a registered trademark of UAS Laboratories.

UAS Labs, located in Wausau, WI, positions itself as the Probiotics Company® and has extensive work in clinical research and trials.

ProDURA® is a Bacillus coagulans probiotic, a unique strain of spore-forming bacteria that supports a positive balance of beneficial to harmful bacteria in the gut.


Overall, we are very favorably impressed with the well-researched, clinically supported, and patented ingredients in the Bio Complete 3 formulation.

Other Ingredients:

This dietary supplement, like other Gundry MD products, is very straightforward about any fillings or additives. In this case, Bio Complete 3 contains the following ingredients in smaller amounts:

  • Microcrystalline Cellulose
  • Hydroxypropyl Methylcellulose
  • Silica
  • Magnesium Stearate

Bio Complete 3 Benefits

As with other dietary supplements, their effectiveness also depends on whether you are following a healthy diet, trying to lose weight, suffer from joint health problems, or want to boost your overall gut health.

Gut Health

The most significant benefits of Bio Complete 3 are its support of a healthy gut lining. This is an area that contains live organisms and where a part of the immune system resides.

When we eat junk foods or unhealthy food, the human gut will begin to lose its healthy bacteria and we can suffer from things like irritable bowel syndrome, digestive issues, and inflammation.

In addition, following a healthy lifestyle, taking probiotic supplements, and eating more dietary fiber promotes good gut bacteria growth.

Evidently, Bio Complete 3 does this for you, taking care of your digestive health without having to take multiple supplements at once.

Other Benefits

Even though these are not the main reasoning behind Bio Complete 3, there are a few more things this Gundry MD product can do for you.

Additional benefits include better digestion, helping you lose weight, balanced bowel movements, reduced junk food cravings, a major boost in energy, and addressing your immune response.

Recommended Dosage For Bio Complete 3

Gundry MD recommends a dosage of two capsules twice per day, preferably before a meal.

Still, taking Bio Complete 3 consistently for optimal gut health is the best choice.

According to Gundry MD, the product is best when you take it in the morning before breakfast and again before dinner. This will give you twenty-four-hour protection.


How Does Bio Complete 3 Perform?

Bio Complete 3 gets high marks for efficacy in reducing bloating and giving you more energy and vitality.

The fiber present in the supplement performs its function by aiding in digestion and relieving abdominal distress. In addition, it can relieve irritable bowel syndrome symptoms.

However, there was no noticeable weight loss while using the product. But it could aid in weight management.

We would still endorse this regimen for anyone with stomach issues and looking for other health benefits.


Is Bio Complete 3 Safe?

Although there are no instances of serious adverse effects from Bio Complete 3, the combination of ingredients may cause some individuals issues, such as bloating, gas, constipation, and thirst.

Of course, we always suggest you consult with your physician before starting any new dietary supplement.

Keep in mind that the Food and Drug Administration does not regulate supplements, however, all Gundry MD products undergo testing and review.

Where to Buy Bio Complete 3

Bio Complete 3 is available on the official Gundry MD website for $69.95 per bottle. You can use this link to get your first bottle for only $49.95.


Furthermore, other discounts are available when you purchase multiple bottles at a time. You can get 3 bottles for $134.95 ($45/bottle) or 6 bottles for $254.70 ($42/bottle). Also, you get free shipping when you purchase either the 3-pack or the 6-pack.

Save an additional 10% off all packages by signing up for a subscription. Still, the subscriptions can be canceled at any time. Although we only recommend signing up for it if you actually want recurring orders.

If you have never tried Gundry MD Bio Complete 3 before, we recommend starting with a single bottle. By doing this, you can see how it works for you. 

Like all of Gundry MD’s products, Bio Complete 3 comes with a 90-day money-back guarantee.

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Bio Complete 3 Review: Final Thoughts

We are favorably impressed with Gundry MD and Bio Complete 3. The company is transparent in its ownership, marketing, labeling, and packaging as well.

Gundry MD uses an independent third-party facility to test all products. They also stand behind their supplements with a 90-day, money-back guarantee.

To conclude, we applaud the formulation with its three patented, clinically tested ingredients, and no proprietary blends.

Also, we give Bio Complete 3 excellent grades for efficacy. This is supported by a plethora of favorable reviews on the company website, which were in line with our findings.

You might be ready to try Gundry MD Bio Complete 3 if you want to take care of your digestive system. It is also good for you if you want to achieve a healthy weight, feel more energy, and help your immunity. 

We recommend you start with one bottle and take one capsule at a time to see if Bio Complete 3 is for you.

More reviews of Gundry MD products:

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Thomas Youngerman

Thomas Youngerman is an entrepreneur and author in the health and wellness space with extensive experience in the supplement industry. He has owned multiple sports nutrition stores and served as the Category Manager and Director of Business Development for a regional chain of nutrition stores. Thomas created a successful line of men’s healthy aging supplements that was distributed in GNC, The Vitamin Shoppe, and Kroger, and later sold to a West Coast corporation. Thomas was previously a certified nutrition coach. He has a strong understanding of nutrition, supplement formulations, DSHEA, cGMP, and FDA regulations.