Qualia Synbiotic Review – Is It Right For You?

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

qualia synbiotic review

Gut health supplements have come a long way since their initial appearance in the supplement market. At first, they typically contained just one or a couple of probiotics, with not much else.

But now, there are supplements with probiotics, postbiotics, prebiotics, fiber, herbs, and various other ingredients to create comprehensive gut support. 

And one of the newer gut health supplements that’s designed to stand apart from the rest, mainly due to its innovative formulation, is Qualia Synbiotic.

In this Qualia Synbiotic review, we’ll take a look at the unique features and formulation of this gut health supplement to see if it’s truly one of the best for digestion and gut health.

About Qualia Synbiotic

Qualia Synbiotic is advertised as an all-in-one gut health supplement, created by Neurohacker Collective. This well-known supplement company has created a variety of products, including Qualia Mind, Qualia Focus, Qualia NAD+, Neurohacker Qualia (a combination of Mind and Focus), and Eternus.

Qualia Synbiotic

The Qualia Synbiotic formula contains 28 ingredients which are designed to cover all major aspects of gut and digestive health. This comprehensive formulation contains a mixture of shelf-stable, spore probiotics, prebiotic fibers, postbiotics, digestive enzymes, and a number of herbs and fermented berries. 

Together, this combination is designed to give you the easiest full spectrum gut health support out there, all with just one scoop per day. Qualia Synbiotic is designed to rebalance the gut microbiome, promote the growth of good bacteria, optimize digestion, and even support other areas of health connected to the gut, such as brain function and immunity. 

That’s why, overall, Qualia Synbiotic is designed for health-conscious individuals who want to optimize not only their gut and digestive health, but total wellness too.

Qualia Synbiotic Benefits

There are many different advertised benefits of Qualia Synbiotic.

The primary claimed benefits are:

  • Improved Everyday Gut Health
  • Reduced Digestive Discomfort
  • Enhanced Gut-Brain Connections
  • Increased Brain Performance & Mood
  • Immune Support
Qualia Synbiotic Powder Scoop

Improved Everyday Gut Health

So many people deal with gut issues on a regular basis. We have a lot of factors in our world that can damage the gut, such as processed food, stress, food intolerances, and chemicals.

Qualia Synbiotic claims to support and improve everyday gut health so you can defend against all of the gut harmers that are out there. The Qualia Synbiotic formula is loaded with probiotics, prebiotics, postbiotics, fermented berries, and herbs. 

These may all restore balance to your gut microbiome, improve gut barrier function, and promote better gut health overall.

Reduced Digestive Discomfort

Digestive complaints such as bloating, constipation, and heartburn are also very common.

Qualia Synbiotic claims to reduce digestive discomfort by using several clinical compounds, including digestive enzymes and prebiotic fibers, such as Fibriss. These may enhance your body’s ability to digest and break down food, allowing you to finally be able to eat meals on a regular basis without discomfort.

Enhanced Gut-Brain Connections

The gut is connected to the brain via the gut-brain axis, so poor gut health could potentially lead to mental or cognitive issues too.

Qualia Synbiotic is advertised to enhance the gut-brain connection so you can improve your mental health too. In particular, Qualia Synbiotic contains specific probiotics, such as Lactospore to support gut health and mood, as well as various herbs to support the gut-brain axis. 

These are also designed to support enteric nervous system function and vagus nerve health, which also leads to improved gut-brain health. 

Increased Brain Performance & Mood

As we mentioned, the gut is related to the brain. And if your gut health is out of whack, you may have an increased risk of anxiety, poor mood, or even brain fog.

Qualia Synbiotic claims to increase brain performance and mood with a variety of natural compounds, such as Aquamin and celastrus paniculatus. Plus, they have three different probiotics that may also support gut-brain health and mood too.

Immune Support

If you have gut issues, you may also have immune problems too since the immune system is yet another area connected to the gut. 

Qualia Synbiotic is advertised to support healthy immune function. They use a number of gut-immune probiotics, such as bacillus clausii, as well as other ingredients designed to enhance immune health and reduce inflammation, including the Berriotics berry blend. 

Overall, Qualia Synbiotic is truly advertised to be a comprehensive supplement for all-in-one gut health improvement. 

But does this supplement actually work?

Keep reading below to find out!

Qualia Synbiotic Ingredients

Qualia Synbiotic contains 28 active ingredients, including various probiotics, prebiotic fibers, postbiotics, fermented berries and herbs, and digestive enzymes. So, it’s definitely a loaded formula.

Some of the ingredients are in blends, so there aren’t 28 listed out ingredients but rather 13 unique ones.

Below are all of the Qualia Synbiotic ingredients:

  • Solnul
  • Sunfiber
  • InstaKombu 
  • Fibriss 
  • N-Acetyl D-Glucosamine
  • LactoSpore
  • Berriotics
  • DigeZyme
  • Fermeric 
  • Celastrus paniculatus Seed
  • Bacillus clausii
  • Bacillus subtilis
  • Aquamin
Qualia Synbiotic Supplement Facts

Solnul (3,500mg)

Solnul is a trademarked form of resistant potato starch, which is a natural prebiotic fiber source. This can help to increase good bacteria in the gut.

In fact, a clinical trial on Solnul discovered that it significantly increased two types of good bacteria while also reducing diarrhea and constipation. And the dose used in Qualia Synbiotic is right on the money.

Sunfiber (2,700mg)

Sunfiber is a trademarked compound of partially hydrolyzed guar gum, which itself is another form of prebiotic fiber. This feeds the good bacteria in the gut and can also produce beneficial postbiotics, such as short-chain fatty acids.

Clinical studies on Sunfiber specifically show that it can enhance gut microbiome health and improve bowel function. 

It’s also used in other quality gut health supplements, such as Bio Complete 3 by GundryMD. 

InstaKombu (1,000mg)

InstaKombu is a trademarked form of kombucha powder. And kombucha is a fermented drink made from black tea and other ingredients. 

This contains a number of beneficial compounds, such as polyphenols, flavonoids, good bacteria, and prebiotic fibers. In general, kombucha has several possible health benefits, including detoxification, enhanced metabolism, better gut health, and support for cholesterol and blood pressure. 

Fibriss (500mg)

Fibriss is a trademarked form of organic baobab fruit powder. This unique-sounding fruit is native to Africa. It grows on the baobab tree, which has even been called the “tree of life” as they’ve been around for millions of years, and each tree can live up to 5,000 years!

And the fruits are highly nutritious. Baobab contains soluble and insoluble fiber, as well as a variety of polyphenols and antioxidants. 

Together, these compounds in baobab fruit support digestion, regularity, gut health, and overall wellness. 

N-Acetyl-D-Glucosamine (250mg)

N-acetyl-d-glucosamine (NADG) is a naturally occurring amino sugar which is involved in maintaining intestinal wall health and function. Supplementing with NADG may be able to enhance intestinal barrier function while also decreasing gut inflammation.

In fact, some research shows that NADG can reduce symptoms of inflammatory bowel disease, such as diarrhea, nausea, and abdominal pain. 

LactoSpore (2 Billion CFU)

LactoSpore is a trademarked form of a probiotic known as Bacillus coagulans. This is a spore-forming probiotic that likely can enhance gut microbiome health and balance out the good bacteria in your gut. In addition, it can support the gut-brain axis, which also benefits mental health.

Nothing illustrates this more clearly than a clinical study that found LactoSpore simultaneously reduced symptoms of irritable bowel syndrome and symptoms of depression. It improved overall quality of life too.

Another product that uses a quality dose of LactoSpore is Primal Harvest Probiotics

Berriotics (100mg)

Berriotics is a trademarked blend of 10 fermented berries, including acerola, mulberry, cranberry, chokeberry, cherry, raspberry, strawberry, blackcurrant, gooseberry, and bilberry. 

All of these berries are loaded with highly absorbable antioxidants, such as anthocyanins and flavonoids. So, it has strong anti-inflammatory effects.

Plus, the fermentation process provides easily absorbed forms of fiber to help feed the gut and digestive tract for optimal gut balance. The combination of polyphenols and fiber may lead to increased gut health, including enhanced number of good bacteria as well as the production of postbiotics to support gut barrier function. 

DigeZyme (100mg)

DigeZyme is a trademarked Mult-Enzyme Complex, which provides amylase, protease, lipase, cellulase, and lactase.

These five digestive enzymes improve the digestion and absorption of carbs/starches, protein, fats, cell walls in fruits and vegetables, and lactose found in some dairy products.

So, together, DigeZyme may be able to reduce digestive symptoms, especially from foods that are typically harder to digest.

DigeZyme is also sometimes used in general health products too, such as Alani Nu Super Greens.

Fermeric (50mg)

Fermeric is a trademarked form of fermented turmeric root powder. On its own, turmeric root is naturally high in curcumin and other anti-inflammatory, health-boosting compounds. 

But the fermentation process may actually enhance the bioavailability and absorption of these compounds, making the anti-inflammatory effects even more powerful.

Plus, the fermentation process results in other beneficial substances, such as inactive good bacteria, metabolites, and postbiotics. 

Altogether, Fermeric may be able to reduce inflammation and oxidative stress, support detoxification, enhance brain function, and support gut barrier function, among other things. 

Celastrus paniculatus Seed (30mg)

Celastrus paniculatus seeds have potential benefits for brain and gut health. For example, these seeds may increase acetylcholine levels while also protecting the brain from inflammation. And together this can enhance cognitive function.

Celastrus paniculatus seeds may also be able to relax the intestines which may lead to better digestion and possibly less constipation. 

Bacillus clausii (10mg) and Bacillus subtilis (5mg)

Bacillus clausii and Bacillus subtilis are both types of spore-forming probiotics. Due to their spore-forming effects, they can resist digestion and end up in the intestines where they have the greatest effects.

Ultimately, these probiotics may support gut barrier function, digestion, and overall gut health. 


Aquamin is a trademarked form of magnesium and many other minerals. These can provide support for bone and joint health, and may also have anti-inflammatory activities.

Does Qualia Synbiotic Work?

Overall, Qualia Synbiotic is very likely to work for gut health and digestion. There are many well-researched ingredients, including several trademarked forms that have been clinically studied, such as Solnul, Sunfiber, DigeZyme, and LactoSpore.

Qualia Synbiotic Drink

And for the most part, the ingredients are dosed at or close to the recommended amounts used in the studies. Some doses are lower, but since there are so many ingredients with similar benefits, this isn’t likely as big of a deal either.

Qualia Synbiotic definitely seems to be able to support gut health, digestion, balanced microbiome, and gut barrier function, while also reducing inflammation, improving immunity, and supporting mood and cognitive function. So, it’s a really good research-backed formula that actually can stand by its claims.

Claims vs. Reality

Of course, not everyone will experience great results. And even for those who do get benefits, they most likely take time to develop. It’s also best to combine this supplement with a healthy diet and lifestyle, especially one that involves figuring out any food intolerances you may have or other factors that disrupt your gut. 

But all things considered, Qualia Synbiotic definitely has a high potential to help with gut health. 

Qualia Synbiotic Powder

How Does Qualia Synbiotic Compare?

Qualia Synbiotic is truly one of the most comprehensive gut health supplements out there. They go above and beyond most other gut supplements by including several beneficial compounds, such as prebiotics, probiotics, postbiotics, digestive enzymes, and beneficial herbs and berries. 

They also have a fully transparent label and use effective doses for the most part. Not to mention their formula doesn’t contain any added nonsense. Additionally, this formula doesn’t require refrigeration and all of the ingredients are shelf-stable, while also highly absorbable. So it’s truly a quality gut health product. 

One popular gut health supplement that’s worth comparing it to is Seed Daily Synbiotic. Seed has a much higher dose of probiotics per serving, and it also contains a higher number of probiotic strains. It also has a prebiotic compound. However, their formula doesn’t have any herbs, digestive enzymes, or some of the other compounds found in Qualia Synbiotic. 

Overall, Qualia Synbiotic is likely the more comprehensive product, whereas Seed Synbiotic is best if you’re looking for a more concentrated product of just probiotics and prebiotics. Seed Synbiotic is quite a bit cheaper at $49.99 for a one-month supply versus Qualia Synbiotic at $79 for 30 servings.

Another supplement that’s designed for comprehensive gut health is Onnit Total Gut Health. Their formula includes probiotics, prebiotics, digestive enzymes, betaine HCL, and various herbs such as ginger and fennel. Together, these provide a well-rounded solution to reduce digestive symptoms, enhance gut barrier function, and promote a healthier microbiome. 

Qualia Synbiotic still seems a bit more comprehensive, although they’re both solid options. Onnit Total Gut Health is a bit high-priced at $75.90 for 30 servings. 

Who is Qualia Synbiotic Best For?

Qualia Synbiotic is best for individuals who want a comprehensive gut health formula to take care of all of their gut and digestive needs, while also offering support for immunity, inflammation control, brain health, and overall wellness.

qualia synbiotic

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Qualia Synbiotic

  • Formula includes Solnul, Sunfiber, Instakombu, and more
  • Ingredients are vegan- non-GMO, and gluten-free
  • Benefits gut health, digestion, gut-brain connections, mood, and immunity

How to Take Qualia Synbiotic

Qualia Synbiotic comes in powdered form. The serving size is one scoop. Neurohacker Collective recommends taking just one serving per day, mixed with water.

Qualia Synbiotic Drink Mix

Is Qualia Synbiotic Safe?

Qualia Synbiotic should be safe for most as it contains all ingredients that are generally recognized as safe when used in appropriate doses.

That said, there are many ingredients in this formula which simply increases the chances of side effects. Possible side effects of Qualia Synbiotic are:

  • Nausea
  • Upset stomach
  • Bloating
  • Other digestive symptoms
  • Headache
  • Dizziness
  • Allergic reactions

Qualia Synbiotic is made in a cGMP, FDA-registered facility, and it is third-party tested for quality, purity, and safety. Furthermore, Quality Synbiotic is vegan, non-GMO, gluten-free, low FODMAP, and free from artificial sweeteners or other artificial ingredients.

This formulation doesn’t require refrigeration either. 

Where to Buy Qualia Synbiotic

You can buy Qualia Synbiotic on the Neurohacker Collective website at this link.

Qualia Synbiotic Website

There are 20 servings (20 scoops) per container. Qualia Synbiotic comes in two flavors:

  • Unflavored
  • Tropical

The one-time purchase price is $79 ($3.95/serving), which is definitely very high. But you can save money with their Subscribe & Save option. You get 50% off your first order, which brings the price down to $39.50 ($1.98/serving). Then, it’s $69 ($3.45/serving) thereafter.

Overall, it’s one of the highest-priced gut supplements out there. But keep in mind that it’s also one of the most comprehensive, well-dosed, and research-backed too. 

Neurohacker Collective also has a 100-Day Money-Back Guarantee

Verdict: Qualia Synbiotic Review

If you’re looking for a comprehensive gut formula, you can’t get much better than Qualia Synbiotic. It truly has all that you need, including prebiotics, probiotics, postbiotics, digestive enzymes, and herbal extracts. Many of these are trademarked forms and the majority have solid evidence behind them.

Together, they offer support for digestion, gut barrier function, microbiome balance, gut-brain support, and overall wellness. Plus, all it takes is one scoop per day, and you don’t need to rely on multiple gut supplements which can get annoying over time. 

Granted, Qualia Synbiotic is priced very high. And we think it could still be a bit lower. But even still, it truly is one of the highest-quality gut formulations out there. So if you’re able to afford it, we definitely recommend it.

Overall Rating:
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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.