Best Supplements for Gut Health

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By Alexa DaFonte

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Best Supplements For Gut Health

Gut health is one of the most important factors in our overall health. Our gut controls so many aspects of our health, including our immune health, hormonal health, skin health, and of course, our digestive health. There are many supplements on the market these days that promote healthy digestion but also work to keep the gut healthy. These supplements may work to add probiotics to your gut or add an acidic component to increase the acidity of your gut, aiding in better digestion.

Regardless of the functioning behind the specific gut health supplement, these supplements are essential to our health. So much of our health begins in our gut, and without a healthy digestive system, our other systems begin to fail us.

Here’s a sneak peek of our top rated gut health supplements. Keep reading to learn more about how and why we chose them.

Product Name Description Discount
Bio Complete 3 Bio Complete 3 Best Overall for Gut Health Save 40%
Multi GI 5 Multi-GI 5 Best for Digestion and Weight Management Save 39%
Total Restore Total Restore Best for Restoring Gut Health Save 40%

Benefits of Supplements for Gut Health

The benefits of healing your gut through supplements extend beyond just healthy digestion. Gut health supplements can benefit proper digestion, a more balanced gut microbiome, better absorption of nutrients, decreased bloating and heartburn, more stable mood, and proper hormonal health. They can also prevent skin issues, support the immune system, promote heart health, and improve anxiety.

These benefits show how far-reaching gut health really is within the body. Although healing your gut through these supplements improves your digestion, it also helps keep your body healthy and stable.

How to Choose the Right Supplement

As with almost any supplement, not all gut health supplements are going to live up to their claims and hype. Additionally, gut health supplements can come in many different forms, from fiber-focused options to peppermint oil choices, making finding the right selection difficult.

Gut health supplements can include a variety of ingredients. Popular ingredients for gut health supplements can typically include probiotic and prebiotic strains, digestive enzymes, fiber, and peppermint oil. Some supplements will focus primarily on certain ingredients, while others may use a blend, with both providing benefits for a healthy gut and proper digestion.

What To Look For

  • High-quality ingredients
  • Professionally-formulated blends
  • The RIGHT healthy bacteria
  • Trustworthy manufacturers
  • Third-party quality testing

What To Avoid

  • Low-quality ingredients
  • Poor/Ineffective blends
  • Fillers
  • Untrustworthy manufacturers
  • Sketchy quality oversight

Top Rated Supplements for Gut Health

At Fitness Clone, we pay close attention when making our supplement selections. We focus on and explore not only supplement formulations and ingredient quality, but also manufacturing practices and company trustworthiness. Here are our top rated supplements for gut health.

Best Overall

Bio Complete 3

by Gundry MD

Bio Complete 3 is the flagship gut health product created by Gundry MD, the leading manufacturer of gut health supplements.

Every Gundry MD supplement is formulated by Dr. Steven Gundry, a cardiac surgeon and gut health specialist. 

Bio Complete contains a blend of probiotics, prebiotics, and postbiotics that work together to optimize gut health.

bio complete 3


  • Simple all-natural formula
  • Supports weight management
  • Supports a healthy gut lining
  • Promotes energy and focus
  • Formulated and backed by Dr. Steven Gundry
  • Manufactured in the U.S. in a cGMP facility
  • 90-day money-back guarantee


  • Can be expensive without any discounts
  • Only includes one probiotic strain

Or Read the Review

Best for Gut Issues

Total Restore

by Gundry MD

Total Restore is another best-selling gut health supplement designed and produced by Gundry MD.

Total Restore’s formula combines 16 all-natural ingredients to promote and support strong, healthy gut lining.

It contains two patented formulas that help reduce gas and bloating, boost energy and focus, and combat junk food cravings.

total restore


  • Includes 16 all-natural ingredients
  • Designed to promote healthy gut lining and reduce fatigue
  • Promotes energy and focus
  • Formulated and backed by Dr. Steven Gundry
  • Manufactured in the U.S. in a cGMP facility
  • 90-day money-back guarantee


  • Can be expensive without any discounts
  • Some users have experienced bloating, gas, and nausea

Or Read the Review

Best for Digestion

Multi-GI 5

by Unify Health Labs

Multi-GI 5 is the best-selling supplement from Unify Health Labs. The supplement is formulated with 12 powerful ingredients to help support gut health.

This supplement is designed to be an “all-in-one” gut health solution for people who want to improve their digestion, manage their weight, and promote a healthy gut.

Multi-GI 5 comes in a Strawberry Lemonade powder that can be mixed with water or smoothies.

multi gi 5


  • Includes 12 powerful ingredients
  • Contains multiple probiotic strains and prebiotics
  • Comes as a tasty, easy-to-mix drink powder
  • Supports healthy digestion and weight management
  • Ingredients subject to 3rd party quality tests
  • 90-day money-back guarantee


  • Proprietary blends don’t show exact ingredient dosage
  • May be overly sweet for some users

Or Read the Review

Best Probiotic

Seed Daily Synbiotic

by Seed

Seed is another of our highest-rated gut health supplements. It is a daily synbiotic that includes a 24-strain probiotic and prebiotic formula. It is designed to not only benefit gut health, but also digestive health, heart health, skin health, gut immune-function, and more.

Seed’s ingredient list contains clinically studied bacteria strains as well as 53.6 billion AFU. 

Seed is a great option for people looking for a simple and effective probiotic.

seed probiotic


  • Contains a 24-strain probiotic and prebiotic formula
  • Clinically tested and studied bacteria strains
  • Designed to provide digestive, gut, and immune system benefits
  • Promotes heart health
  • Clean formula (soy-free, dairy-free, corn-free, gluten-free)
  • Nested ViaCap delivers an average of 100% of probiotic dose


  • Some users have experienced an adjustment period with discomfort, nausea, and tightness
  • Often out of stock
  • No discounts available

Or Read the Review

Supplements For Gut Health FAQ

What are the different types of gut health supplements?

There are a lot of different gut-healing supplements on the market that help heal the gut in specific ways. Below are the more popular types of gut-healing supplements and some of their associated functions:
Probiotics (help balance the gut microbiome by adding healthy bacteria)
Peppermint Oil (helps with bloating and IBS/ constipation)
Ginger (helps with nausea, vomiting, and stomach discomfort)
L-glutamine (helps with constipation, diarrhea, and helps you absorb nutrients better)
Psyllium (contains a large amount of fiber that aids in proper bowel movement habits)
Apple cider vinegar and other acidic compounds (healthy acids add acidity to your gut, which is beneficial if you do not have enough stomach acid to break down your food)
Digestive enzymes (help break down food more readily)

Should you take supplements for gut health?

Gut-healing supplements can be taken by pretty much anyone. However, it’s important to note that you should always consult with a doctor before using any of these supplements. Gut health supplements become especially crucial for individuals suffering from digestive disorders, including IBS, Crohn’s disease, constipation, nausea, vomiting, and diarrhea.

They can also be beneficial for immuno-compromised individuals as nutrient uptake occurs in our guts

Depending on your specific health situation, you may require one or a combination of any of these gut-healing supplements. Do your research on your specific condition and consult with your doctor to find a product or type of supplement beneficial for you.

Do gut health supplements really work?

Gut-healing supplements are all over the market these days. It really depends on what the specific product is, and its ingredients in terms of determining whether or not it’s effective. It also depends on your health condition, as well. For example, for someone with IBS in the form of constant diarrhea, supplements that help you go to the bathroom, like fiber supplements (Metamucil, psyllium husk), might not be the best option. Additionally, if you’re looking to heal constipation issues, some supplements like peppermint oil may be more beneficial for someone, whereas a probiotic/prebiotic blend may be more beneficial for another person. It really comes down to the specific product and its reviews/efficacy, as well as your unique health condition.

Are there dietary sources that can help gut health?

Gut health is very important, but it does start with your diet and lifestyle. It’s important to eat a balanced diet filled with fruits, vegetables, whole grains, and especially fiber. Drinking enough water and engaging in some form of exercise every day also contributes to a healthy gut. Additionally, stress also impedes our gut health, so finding ways to de-stress can benefit your gut immensely. Some dietary sources that help heal the gut include Probiotic and prebiotic-rich foods (kimchi, yogurt, leafy greens, beetroot, kombucha), chickpeas and other beans, whole-grain bread, Psyllium husk powder, flaxseeds, chia seeds, lentils, ginger, avocado, papaya, salmon, banana, bone broths, brown rice, miso, and broccoli.

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Alexa DaFonte

With a degree in Nutrition and Health Sciences from the University of Massachusetts Amherst, Alexa brings a vast knowledge of nutritional sciences, especially as it intersects with modern health and wellness. Due to her passion for a healthy lifestyle, she enjoys spreading awareness of the science behind many of her nutrition practices.