PROBIO-50 Review – Is This Cutler Nutrition Probiotic Worth Buying?

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

probio 50 review

Gut health optimization is at the forefront of health and wellness today, and for good reason. Many people today struggle with gut issues, whether it’s bloating, nausea, constipation, or other issues. And the thing is, an unhealthy gut means an unhealthy body, since the gut is connected to so many systems.

Within gut health optimization, one of the best things to do is to increase the health of the microbiome, and there are many supplements that claim to help do this. One such supplement is called PROBIO-50 by Cutler Nutrition.

So, does this probiotic work? How are the ingredients? And is it really worth the price? In This PROBIO-50 review, we’ll answer all of those questions are more. Now, let’s dive in and find out if PROBIO-50 is worth the purchase!

cutler nutrition probio 50

About Cutler Nutrition PROBIO-50

Cutler Nutrition PROBIO-50 (here on referred to as PROBIO-50) is a multi-strain probiotic blend supplement created by Cutler Nutrition. This supplement company was created by football player Jay Cutler and has produced a variety of other supplements in addition to PROBIO-50, such as Prevail Pre-Workout, Amplify Pre-Workout, and Total Iso Protein.

PROBIO-50 contains over 50 billion CFUs (colony-forming units), but what makes it unique is its inclusion of a specific postbiotic ingredient called CoreBiome designed to maximize the power of all of these probiotics. Essentially, this PROBIO-50 is designed to increase the number of good bacteria in your gut as well as enhance the overall function of the gut via CoreBiome, which is supposed to create benefits not only for your gut, but your overall health too.

PROBIO-50 Benefits

With its influence on gut flora, the microbiome, and intestinal function, PROBIO-50 is advertised to improve digestion, eliminate bloating, improve immunity, decrease inflammation, and increase energy levels. 

cutler nutrition probio 50 improved digestion

Improved Digestion/Reduced Bloating

The inclusion of probiotics and CoreBiome are advertised to improve all areas of digestive health, such as better nutrient absorption, reduced gas/diarrhea. It is also designed to eliminate bloating, especially that occurs from heavy meals or indigestion. 

Improved Immunity

The gut and the immune system are intricately related, so it’s no surprise here that PROBIO-50 is supposed to enhance immune system function and promote greater overall wellness. 

Lower Inflammation

CoreBiome in PROBIO-50 is also supposed to regulate the inflammatory response and fight off oxidative stress, leading to reduced intestinal inflammation and overall greater gut health. 

Increased Energy

Finally, PROBIO-50 is designed to increase energy levels simply by enhancing nutrient absorption and clearing out waste products more effectively. Essentially, it’s designed to give you an energy boost by creating allowing you to make the most use out of the nutrients you take in.

These are some awesome benefits, and ones that many people in the modern world could use right now. But how likely is PROBIO-50 to deliver on its promises? Read on to find out!

PROBIO-50 Ingredients

PROBIO-50 comes in capsule form, and the serving size is 3 capsules. So, here is what’s in each serving of PROBIO-50:

  • Tributyrin (as CoreBiome 30%) (1000mg)
    • Yields 300mg
  • Vegan Multi-Strain Probiotics (50 Billion CFU), which contains these strains:


    • Lactobacillus acidophilus
    • Bifidobacterium breve
    • Lactobacillus fermentum
    • Lactobacillus rhamnosus
    • Lactobacillus gasseri
    • Lactobacillus plantarum
    • Bifidobacterium lactus
    • Lactobacillus casei
    • Lactobacillus paracasei
    • Lactobacillus salivarius
    • Bifidobacterium longum
    • Bifidobacterium bifidum
    • Bifidobacterium infantis
    • Streptococcus thermophilus

That’s a mouthful to read, but just understand that these are all different probiotic strains. 

cutler nutrition probio 50 supplement


PROBIO-50 is unique as a probiotic supplement in that it also contains CoreBiome, which is a form of tributyrin. Tributyrin is a short-chain fatty acid (SCFA) that acts as a postbiotic. And postbiotics are essentially byproducts of the fermentation process carried out by probiotics. 

There is also prebiotics, and these are what the probiotics eat. So, the overall process is that after probiotics eat prebiotics, they produce postbiotics. I know, that’s a lot of “biotics” to differentiate, but that’s the general idea of what goes on in the gut. 

Now, there are many different benefits of postbiotics, including the form tributyrin. For example, postbiotic supplementation is proven to increase the function of the immune system and significantly decrease inflammation. Additionally, postbiotics help increase the integrity of the gastrointestinal system and decrease leaky gut and other gut health problems. 

Moreover, postbiotics indirectly have benefits on the probiotics and overall gut microbiome. 

While more research is needed, the current status says that postbiotics are effective for a wide variety of problems, including inflammation, IBS and other gut health issues, neurological disorders, and even certain cancers. And CoreBiome is a well-researched, effective form of postbiotics as it can reach both the small and large intestine, and it has a high bioavailability. 

Vegan Multi-Strain Probiotics

The other ingredient is the Vegan Multi-Strain Probiotics blend which contains 14 different probiotic strains and totals around 50 billion CFUs. 

Probiotics, as mentioned, are the “good” bacteria. They reside in the GI system and directly influence our gut health, which further influences overall health. Probiotics are also necessary to ward off bad strains of bacteria and keep the gut at an optimal ratio of good to bad bacteria. So, via probiotic supplementation, a large number of probiotics enter into the gut, which then positively impacts our health. 

Unsurprisingly, probiotic supplementation improves GI health and digestion and can reduce bloating, nausea, constipation, IBS, and other concerns. But, probiotic supplementation is also able to reduce inflammation, curb allergy symptoms, improve immune health, increase fat metabolism, and even reduce depression and anxiety and improve some aspects of cognitive function, among other things!

Now, you’ll notice that PROBIO-50 uses primarily various strains of Lactobacillus and Bifidobacterium, and this is great since these are two of the most well-researched strains. 

For best results, research shows that at least 10 billion CFUs are typically needed.

Does PROBIO-50 Work?

After reviewing the ingredients, it’s highly likely that PROBIO-50 will work as a gut health supplement. There is so much research behind probiotics in general, and there is also a lot of evidence behind CoreBiome and other postbiotics, although a lot of the information and testing has been done in animals rather than humans. 

cutler nutrition probio 50 and total iso

Also, both of these main ingredients are at the right doses, which should lead to the most effective results. 

Essentially, it is likely that PROBIO-50 will improve many aspects of gut health as well as overall health, given the connection between the gut and the rest of the body (and the research that proves all of this). Primarily, it is likely that PROBIO-50 will also decrease inflammation, increase immune function, and support digestion, but it also may have benefits for energy, cognition, and mental health too. 

Claims vs. Reality 

One thing to note, however, is that the extent to which you benefit from this product may depend on how severe your conditions are. Probiotic supplementation does appear to benefit healthy people and those with an already solid microbiome, but the benefits aren’t as pronounced as they are in people with various health conditions. This isn’t a bad thing at all, though, since most of the people who likely want to try gut health supplements are already experiencing many different problems and symptoms. 

Another thing to note is that different strains produce different benefits, and since there are so many different strains in PROBIO-50, it may not be the exact combination you need for your specific health problems. For example, maybe you just need specific strains that improve your mental health, in which taking in other strains is unnecessary. 

Yes, all of the strains provide benefits, but it’s unclear exactly how much of each strain is in here and to what degree they will affect different health outcomes. 

Also, probiotic supplementation takes time to work, so don’t expect improvements overnight for immune health, inflammation, energy, digestion, and so forth. Probiotic supplementation has to be chronic, and you also have to ensure you’re still eating right and living a healthy lifestyle to reap the full benefits. After all, you can’t out-supplement a bad diet and lifestyle (though probiotics may come the closest out of any supplements to be able to try and do so). 

Who is PROBIO-50 Best For?

With all of this considered, PROBIO-50 is best for people with general health complaints and problems related to poor digestion, inflammation, immune health, and energy levels. This isn’t necessarily for people with severe problems related to any of those specific domains since a more targeted supplement would be better in those cases. But PROBIO-50 is likely a solid choice if you’re just someone looking to improve your overall gut health and the general benefits that come with that. 

Cutler Nutrition Probio-50 Supplement Bottles

Is PROBIO-50 Safe?

People are sometimes disheartened when a probiotic/gut health supplement leads to an increase in some of their symptoms, but this is almost always due to the internal battle of “good vs. bad bacteria.” And as the body adjusts to the influx of good bacteria, these symptoms will go away and (usually) improve significantly. Also, some of you may experience no side effects at all. But here are some possible ones:

  • Temporary increase in gas and bloating
  • Headache 
  • Allergic reactions/sensitivities

Also, PROBIO-50 is vegan-friendly, non-GMO, gluten-free, and free of fillers and dyes. 

Where to Buy PROBIO-50

You can get your hands on PROBIO-50 by going to the Cutler Nutrition website at this link

jay cutler nutrition probio 50 website

Each bottle contains 30 servings (90 capsules). The price for a one-time purchase is $49.99 ($1.67/serving), or you can choose the Subscribe and Save option, which lowers the price by 15% to $42.49 ($1.42/serving)

PROBIO-50 is a moderately expensive product, so it’s important to keep in mind that it’s best to take it every day when factoring in the price.

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PROBIO-50 Review Ratings

  • Ingredient Quality: 4.3
  • Ingredient Dosage: 4.4
  • Effectiveness: 4.0
  • Safety: 4.4
  • Value: 3.5
  • Company Trustworthiness: 4.2

Overall Rating:
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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.

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