Longevity Max Review – Is This Gundry MD Supplement Effective?

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By Thomas Youngerman

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

longevity max review

Dr. Steven Gundry and his company, Gundry MD, have produced some of the most well-known supplements out there. With a focus on quality and research, Gundry MD supplements have had the market buzzing for quite some time.

One such supplement is Gundry MD Longevity Max. This supplement is designed to help you feel younger and more energized by supporting your natural levels of NAD and sirtuins.

Longevity Max for Energy

So, now the question is, does this Gundry MD supplement measure up to the claims?

In this Longevity Max review, we’ll take you on a thorough tour through the ins and outs of this Gundry MD supplement. We’ll not only discuss this supplement’s ingredients and benefits, but we’ll provide you with more information on Dr. Steven Gundry, Gundry MD, and what anti-aging really means.

Ready to find out if you should make this Gundry MD supplement your next purchase? Let’s get started with this Longevity Max review!

About Gundry MD and Dr. Steven Gundry

Doctor Steven Gundry, founder of Gundry MD, is one of the leading experts in the natural products space on digestive health and the microbiome. He is one of the most highly educated individuals in our industry, a Yale graduate with honors, the Georgia School of Medicine, residency at the University of Michigan. The doctor holds patents on some incredibly complex tools used in heart surgery, is a best-selling New York Times author, and was one of the pre-eminent heart surgeons in the world before shifting his focus to preventative health. His company, Gundry MD, adheres to some of the best-in-class practices and policies in the world of supplementation:

  • All products are produced in the US in an FDA-certified cGMP-compliant facility (current Good Manufacturing Practices).
  • Products and ingredients are tested in an independent third-party facility for quality and purity. 
  • Whenever practical, products feature full label transparency with no proprietary blends.
  • Each product is doctor-formulated, often using patented and trademarked ingredients, supported by clinical trials to support structure-function claims.
  • The company is conservative in its marketing and health claims.
  • All products come with a 90-day Money Back Guarantee if the customer is unsatisfied with their results. 
Doctor Steven Gundry

If Doctor Gundry is the industry expert on digestive health, Dr. David Sinclair, the Australian-born genetics researcher at MIT and Harvard University Medical School, is the expert on aging and sirtuins. If his name is familiar, it’s probably due to his popularizing Resveratrol in the early 2000s. We will cite Dr. Sinclair’s studies, and quote his theories extensively, in layman’s terms, to help you better understand the subject matter and why our Doctor Gundry may once again be on to a cutting-edge product for better health. 

Anti-Aging – Extending Life / Prolonging Vitality 

Most anti-aging protocols have focused on mitigating the effects of aging, not extending life but lengthening your healthy lifespan, the portion of your life spent without disease or disability. Although we live longer as a species, we are not necessarily living better, with many of our elderly suffering years of debilitating physical and mental illnesses. 

Aging is our most significant risk factor for serious illness, heart disease, cancer, diabetes, or dementia, and we all age. The older one gets, the less trauma required to result in serious illness and eventually death. In Dr. Sinclair’s best-seller, Lifespan, he makes a compelling argument that we should treat aging as an illness, rather than treating the resulting diseases, in what he refers to as the “whack a mole” approach.

The best minds in science have searched throughout history for the “aging gene” in the hopes of manipulating the gene or turning it off completely. There is, it seems, no single gene responsible for aging and death; rather, scientists today agree on eight-nine “hallmarks of aging,” including things such as:

  • DNA Damage
  • Chronic Inflammation
  • Telomere shortening
  • Mitochondrial dysfunction
  • Genes turning on and off
  • Senescent cells

According to Dr. Sinclair, “address one of these hallmarks, and you can slow down aging – address all of them, and you might not age.”

Longevity and Vitality Genes

Scientists have discovered more than two dozen “longevity genes” within our genome that can extend both the average and maximum lifespans in many organisms. (Note: We have positively impacted the average lifespan in humans by reducing infant mortality and through medical innovation; however, we have not affected the maximum lifetime). These longevity genes not only increase the maximum lifespan – but also make the organism healthier. Thus, they can also be thought of as “vitality genes.” They respond to damage and help fix it. 

Gundry MD - Genes

To quote Dr. Sinclair,

“These genes form a surveillance network within our bodies, communicating with one another between cells and between organs by releasing proteins and chemicals into the bloodstream, monitoring, and responding to what we eat, how much we exercise, and what time of day it is. They tell us to hunker down when times are tough and to reproduce when not.”

Sir2 – Sirtuin Genes and NAD

Finally, we arrive at the NAD and sirtuins targeted in Dr. Gundry’s Longevity Max product. Sirtuins (named for the Sir2 gene first found in yeast) are longevity/vitality genes. Mammals have seven sirtuins, Sirt1 through Sirt7. These sirtuin genes, the “guardians of the genome,” are made in virtually every cell in the human body, and their role in our health is crucial:

  • They combat chronic inflammation – a risk factor for cancer, Alzheimer’s, and heart disease.
  • Aid in cell health and boost mitochondria – the power packs of cells.
  • Prevent muscle wasting (sarcopenia), osteoporosis (a weakening of the bones), and macular degeneration. 
  • They are responsible for DNA repair
  • Increase exercise endurance
  • Aid in cognition
  • Help with weight management

The other longevity genes include mTOR, and AMPK, two sets of genes that perform similar functions when faced with biological stress. These genes decline as we age and become complacent in the absence of a healthy diet and exercise, leading to susceptibility to disease.

These longevity genes are dependent on a molecule called NAD (nicotinamide adenine dinucleotide) to function. NAD is an essential coenzyme involved in numerous biochemical reactions – it helps turn nutrients into energy and regulates other critical cellular functions. Unfortunately, NAD also gradually declines as we age, like essential hormones, strength/muscle mass, and VO2 max, resulting in reduced sirtuin activity. Less longevity/vitality gene activity is thought to be a significant contributor to aging and a primary reason our bodies develop illnesses as we age.

How to Support Sirtuins as We Age

You may remember from our introduction that Longevity Max works by supporting NAD and sirtuins. Several established compounds, each a form of Vitamin B3, niacin, are precursors to NAD and promote sirtuin activity. Tissues in the body convert absorbed niacin into its main metabolically active form, NAD.

Nicotinamide riboside (NR) is perhaps the best-known, most highly advertised form of B3, a precursor to NAD. Nicotinamide mononucleotide (NMN), another form of B3, is converted into NAD+, which is a cofactor of sirtuins and other DNA-repairing molecules. And of course, Dr. Gundry’s (NAD3™ Matrix)™, a combination of B3, wasabi extract, and theacrine. 

What is Longevity Max?

Armed with this brief history of how we age and the role of NAD and sirtuins, we hope it makes it a bit easier to understand Dr. Gundry’s explanation that Longevity Max supports them to make you feel youthful and energetic at any age. 

Longevity Max by Gundry MD

Longevity Max, like all Gundry MD products, is doctor-formulated. The product comprises five primary ingredients, including two patented compounds, (NAD3 Matrix), and NeuroFactor (Coffee Fruit Extract), and is in vegetable capsule form, so it is Vegan friendly. Each bottle contains thirty servings. Longevity Max adheres to all Gundry MD corporate practices and policies as cited above. Although NAD3 appears as a proprietary blend, it is a finished patented compound with its dosage (312 mg), correctly displayed on the ingredient panel.

Longevity Max Ingredients

Longevity Max has a complex formulation that includes Vitamin B3 (Niacin), a mineral component (Copper), a proprietary, trademarked blend (NAD3 Matrix), Rosemary Extract, and NeuroFactor Whole Coffee Fruit Extract.  

Longevity Max Ingredients

Proprietary Blend (NAD3 Matrix) 312 mg

Per the Supplement Facts panel, this ingredient is patent-pending from Compound Solutions Inc. In a somewhat unique approach, the trademarked NAD3 from High Performance Nutrition (HPN) is combined with two additional ingredients to form a separate patented compound, the Matrix. We analyze this trademarked blend in a different sequence than how it is portrayed on the Gundry MD website. The company speaks first to the B3 component; however, it’s important to know that components are listed according to each ingredient’s amount in the blend when analyzing proprietary blends. Wasabi Extract is the most plentiful ingredient, followed by Theacrine and finally B3.

Wasabi Extract

A root from the Japanese cruciferous vegetable with antibacterial and anti-inflammatory properties that also helps support metabolism.


A naturally occurring chemical similar to caffeine used in sports nutrition, cognition, and anti-aging supplements to support sirtuin activity. Compound Solutions is an industry leader in theacrine supplementation, featuring their patented TeaCrine. 

Cuprous Niacin as NAD3

This patented form of niacin is the second-generation NAD support ingredient from HPN’s, Nicotinamide riboside (NR). NAD3 is an essential cofactor for biological pathways and a precursor to NAD. In-house clinical research by HPN supports its superior absorption and bioavailability.

Rosemary Extract 150 mg 

A rich source of antioxidants and anti-inflammatories, rosemary is used to boost the immune system, improve blood circulation, and in cognition products for memory and focus.

NeuroFactor Whole Coffee Fruit Extract 100 mg

Patented and trademarked by FutureCeuticals, this clinically studied coffee extract is used extensively in brain health products.

Gundry MD Longevity Benefits

As noted, the company is typically conservative in stating its health benefits and avoids scientifically supported structure-function claims. The benefits cited on the Gundry MD website are fairly modest and somewhat ambiguous, feel younger, stronger, sharper, healthier, and more vibrant as you age. Additional benefits include stamina, vitality, endurance, support against free radical-induced oxidative damage, and improved mood and focus. 

Longevity Max - Feel Young

Gundry MD makes no claims relative to life extension or disease avoidance. By contrast, a major competitor in the NAD support space lists age-related brain degeneration and a reduced risk of heart disease as benefits of their product. We prefer the Gundry approach unless compounds are clinically proven in scientific studies to deliver the purported benefits. 

Recommended Dosage

Per the Gundry MD website, take one capsule in the morning, preferably before your first meal. The site states that you may experience increased energy within the first 10-20 minutes as your body naturally produces NAD and sirtuins. Given the product contains caffeine and theacrine, both stimulants, this would be logical. However, it is also a slick marketing ploy to suggest a response, even if only a placebo effect.

How Does Longevity Max Perform?

Not surprisingly, most product reviews attribute increased energy to the product. We do not doubt that B3, theacrine, and caffeine will boost your energy. Further, we know that NAD helps turn nutrients into energy. The comprehensive formula in Longevity Max should increase NAD, stimulate sirtuin activity and provide the benefits promised by Gundry.

Longevity Max Capsule

Will it extend life? Increase your healthy lifespan? Protect against illness and disease? Only time will tell. That said, the expert in the field, Dr. Sinclair, takes a B3 supplement religiously to stimulate sirtuins to protect his body’s cells, instructing them to hunker down and not replicate during times of biological stress.  

Additional Methods to Promote Sirtuin Activity

Stressors, such as exercise, calorie restriction, intermittent fasting, and hot and cold trigger sirtuin activity without damaging cells. Adding these to a NAS support product regimen should yield additional benefits and provide additional support. 

Is Longevity Max Safe?

Longevity Max is generally considered safe for healthy adults at the prescribed dosage, and the company has not reported any adverse reactions to the product. Women who are pregnant or breastfeeding should not use the product due to the Rosemary Extract. 

Longevity Max - Healthy Aging

Longevity Max is essentially a B3 Vitamin. Some individuals may be allergic to B, and others may experience a niacin flush with certain B-vitamins – typically, those taking concentrated dosages in pre-or intra-workout sports supplements. 

Other potential side effects include:

  • Nausea
  • Dizziness
  • Headaches
  • Diarrhea
  • Indigestion

As always, before adding any new supplement to your regimen, we suggest you speak with your healthcare professional.

Where to Buy Longevity Max 

Longevity Max is only available on the official Gundry MD website. The product is not offered for sale on any other online stores. Fortunately, the Gundry website offers specials, quantity discounts, the VIP program, and a 90-day money-back guarantee, only accessible through Gundry’s site.

Gundry MD Longevity Max Website

Longevity Max is available for purchase in three sizing options with discounts for purchasing larger quantities. Below, we will detail the pricing and savings you can expect.

Longevity Max Pricing:

With the discounts for purchasing multiple bottles, you can bring the $99.95 per bottle price of Longevity Max down to $92.95/bottle when you order 3 or to $89.95 per bottle when you order 6. Additionally, customers who participate in the Gundry MD’s VIP program can enjoy discounts up to 60% off retail with a subscription.

Longevity MaxSave up to 10% on Longevity MaxWe scour the web for the best deals on supplements. Want to get up to 10% off your order of Longevity Max? Click the button below to get this deal!GET THE DEAL

Pricing in the NAD support category varies dramatically. Several category leaders retail at the $40.00 price range for a thirty-day supply, while others demand a premium price point. At a 60% discount, Gundry VIP pricing for Longevity Max becomes competitive with the more mainstream items – at the full list price of $99.95, this Gundry MD product is in the premium range.  

In Summary: Longevity Max Review

Sirtuin genes play such essential roles in addressing stress, combatting chronic inflammation, in cell health, boosting mitochondria, and DNA repair that ensuring their ability to function is crucial. In fact, adding more sirtuin genes to mice in clinical studies helped them live longer. We support these longevity genes by providing sufficient NAD as we age. Longevity Max by Gundry MD provides the NAD3™ precursor to NAD required to promote healthy sirtuin activity. 

As Dr. Sinclair states, if we address just one of the hallmarks of aging, we can slow down aging. Address all of them, and you might live younger longer.

More reviews of Gundry MD products:

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Thomas Youngerman

Thomas Youngerman is an entrepreneur and author in the health and wellness space with extensive experience in the supplement industry. He has owned multiple sports nutrition stores and served as the Category Manager and Director of Business Development for a regional chain of nutrition stores. Thomas created a successful line of men’s healthy aging supplements that was distributed in GNC, The Vitamin Shoppe, and Kroger, and later sold to a West Coast corporation. Thomas was previously a certified nutrition coach. He has a strong understanding of nutrition, supplement formulations, DSHEA, cGMP, and FDA regulations.