Natural Stacks CILTEP Review – Does This Supplement Work?

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By Leslie Waterson

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


CILTEP is a natural nootropic designed for mental performance. The question is, is it worth taking?

We’ll start this review with a bit of information about the parent company, Natural Stacks. The company was co-founded in 2013 by Ben Hebert and Roy Krebs. Industry sources estimate that they currently have 58 employees generating $10.6 million in sales. Although they are a relatively new and small company, they appear to be doing several things the right way. 

They position themselves as “the world’s first open-source supplement company.”

They believe in transparency and Full Label Disclosure; no proprietary blends, and all ingredients and the amount of each component is identified on the label. They even go so far as to allow you to track the source of the ingredients to the supplier. They refer to this as their Ingredient Traceability program. And they use “3rd Party Lab Testing.”

We admire the sound of this approach, and we’ll delve into what it means in greater detail in this review.

So, let’s take a closer look at Natural Stacks’ brain enhancer, CILTEP (note that since our review, CILTEP has now become NEUROFUEL). In this CILTEP review, we’ll dive into this supplement’s key ingredients, benefits, claims, and pricing, we’ll also discuss how it compares to other mental performance supplements and provide a numerical value to its efficacy and its cost.

Let’s dive in!

CILTEP Mental Performance Supplement

What is CILTEP 

The product is positioned as a natural nootropic supplement for mental performance.

The Natural Stacks site claims CILTEP is “the premier natural nootropic for obtaining laser-like focus for hours and creating long-lasting memories. Designed to induce long-term potentiation in the brain, which is crucial to the formation of new memories.”

Most nootropics address focus and memory. CILTEP is the first in our experience that touts creating new, long-lasting memories. 

CILTEP’s Key Ingredient

CILTEP’s formula contains:

  • Vitamin B6 – 5mg
  • Artichoke Extract – 900mg
  • Coleus Forskolin Extract – 20 mg
  • L-Phenylalanine – 500mg
  • Acetyl-L-Carnitine – 750 mg

The label remains true to the transparency promise as each ingredient, and its precise amount is spelled out on the Supplement Facts label. 

Key Ingredients: Premium Artichoke Extract. Artichoke extract contains Luteolin, a safe, natural inhibitor of PDE4.  PDE4 inhibitors have been shown to have significant nootropics effects, including increased cognition, improved long term memory, increased wakefulness, and neuroprotection. Forskolin, derived from Coleus Forskohlii activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP.

Additional purported benefits of Artichoke Extract include fat burning, weight loss, and lowering cholesterol. When used in combination with Forskolin, as is done in CILTEP, there is a synergistic effect whereby they benefit PDE4 and cAMP to improve LTP (Long Term Potentiation) and memory.

L-Phenylalanine, is an essential amino acid. lists the potential benefits of this ingredient in combatting depression, ADHD, arthritis, pain, and weight loss. L-Phenylalanine can also be converted to a substance (phenylethylamine) which occurs naturally in the brain and which elevates mood 

Acetyl-L-Carnitine, another amino acid, is used frequently in supplement products for its benefits in supporting memory, reducing fatigue, and preventing Alzheimer’s. 

The CILTEP formula is patented by the U.S. Patent and Trademark Office. The product is non-GMO, Gluten-free, and contains no artificial colors or preservatives. 

CILTEP Mental Performance Supplement Ingredients

CILTEP Dosages

The recommended dosage for CILTEP is 1-3 capsules in the morning immediately upon waking on an empty stomach. You should not take more than three capsules per day. Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results. The product can be taken daily; however, the company suggests taking 1-2 days off per week.

Benefits of CILTEP

When discussing the benefits of CILTEP, the company emphasizes the brain’s ability to form vivid, long-lasting memories and remain motivated and focused for hours. Other benefits cited by CILTEP consumers:

  • Beats Brain Fog
  • Increased motivation and mental endurance
  • Improved concentration and alertness
  • Improved mood and social ease
  • Enhanced ability to study

The company also introduces the concept of long-term potentiation LTP. They explain that LTP is a crucial mechanism involved in the formation of new memories and the strengthening of neural synapses.

Per Wikipedia: 

“In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength.”

Who Needs CILTEP

As opposed to several other nootropics we have reviewed CILTEP appeals to a much younger crowd. Many of the reviewers were in the 25 – 35 age bracket. Students, business-people, professors, and executives who are seeking extra energy, a little extra motivation, a competitive edge, and just feeling sharper all seem to enjoy the benefits of the product. 

CILTEP Mental Performance Supplement Health Facts

Does CILTEP Actually Perform – the Claims versus the Reality

The Natural Stacks site tracked nearly 4,000 customer reviews with a 4.7 satisfaction record. We did not find any negative reviews; however, noted that the degree of efficacy varies from person to person. 

Tim Ferriss, of 4 Hour Body fame is a fan of the product. It should be noted Ferris is not a doctor, scientist, or nutritionist. However, he does serve as a guinea pig and tends to screen out the pretenders.

Many reviews on unbiased sites were positive for increased focus, better learning, more motivation, and improved memory.

CILTEP Mental Performance Supplement User Reviews

Potential Side Effects of CILTEP

If used as directed, there should be no adverse side effects from using CILTEP. That said, there have been several reports of mild side effects such as drowsiness and reduced choline levels in the body.

CILTEP Pricing

You can purchase CILTEP directly from the official Natural Stacks website here. A one-time purchase will cost $29.95. If you really like CILTEP, though, you can choose to use their subscribe & save 20% option which brings the price down to $23.96/bottle.

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Most supplements come in thirty serving sizes, basically an industry-standard, one-month supply. CILTEP deviates from this by packaging their product in a twenty serve bottle. That said, they do recommend you refrain from using the product daily, recommending taking one to two days per week off the product. We assume this recommended usage pattern is their rationale for packaging this way.

In Summary

Natural Stacks seems to run a great business. They say the right things from a consumer’s perspective, such as their Full Label Disclosure, the Ingredient Traceability program, and their “3rd Party Lab Testing.” They appear to work with a limited number of distribution partners and enforce their pricing policies. 

As promised in our intro, let’s circle back to those consumer promises:

Transparency – Full Label Disclosure

  • The company delivers on its promise not to use proprietary blends
  • Each ingredient is listed
  • The amount of each component is listed

Traceability Program

A review of the website includes a listing of the ingredient suppliers – they do not trace ingredients to their actual source, but most companies do not divulge their ingredient suppliers. As an example, a competitive nootropic includes an element, CERA-Q. Although this company does not list its supplier, a search of the internet will identify the ingredient manufacturer, Novel Ingredients

3rd Party Lab Testing

The company engages Intertek to ensure the potency and purity of every ingredient after each production. Many reputable companies have a similar process wherein each batch of a product receives a Certificate of Analysis.

So, although the company positioning, “the world’s first open-source supplement company,” represents a bit of marketing speak, they do deliver on the promised aspects of transparency. 

In the final analysis, if you’re seeking a boost in cognition, or suffering from a bit of “brain fog,” we think CILTEP may be worth trying. 

Other Natural Stacks Supplements

Overall Rating:
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Leslie Waterson

Leslie has been passionately involved in the health and fitness industries for over a decade. She is constantly reviewing the latest scientific research and studies in order to take a research-backed approach to lifestyle optimization. Her main areas of interest include nutrition and supplementation. Leslie shares her findings on Fitness Clone to help other health enthusiasts choose the products and routines that will help them achieve their goals.

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