SIBO Breakthrough Kit Review – Is This Supplement Kit Right For You?

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By Callie Miller, MS, RD, LD, CPT

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

sibo breakthrough kit review

Small Intestinal Bacterial Overgrowth, commonly known as SIBO, is gaining awareness in the medical field. SIBO occurs when bad bacteria colonizes in the small intestine, leading to uncomfortable symptoms such as bloating, pain, constipation, indigestion, gas, diarrhea, fatigue, malabsorption, nausea, vitamin deficiencies, and weight loss. There are currently no direct studies on how many people are impacted by this each year, but it is very common in those who have been diagnosed with Irritable Bowel Syndrome (IBS). In fact, about 55% of people who have IBS also have SIBO.

Some people believe in taking a regular probiotic that contains Lactobacillus Acidophilus, one of the most common strains for general wellness. Although this can help the average person, taking the wrong probiotic strains can actually make SIBO worse. Dr. Amy Myers created a SIBO Breakthrough Kit specifically designed to rid the small intestine of this bacterial overgrowth and help repopulate the digestive tract with the right probiotic strains. 

So, is this kit worth the purchase? Let’s dive into this SIBO Breakthrough Kit review so you can learn more about this product and whether or not it’s worth buying.

About SIBO Breakthrough Kit

The creator of this supplement, Dr. Amy Myers, is the author of multiple books including The Autoimmune Solution, The Thyroid Connection, and The Autoimmune Solution Cookbook. She is a passionate functional medicine doctor and has helped thousands of patients with autoimmune, thyroid, and digestive issues. Along with her practice, she has launched many other supplements to further help patients reach their greatest health potential.

Other Amy Myers MD Reviews:

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The SIBO Breakthrough Kit contains two different formulas: Microb-Clear and Primal Earth Probiotic. The Microb-Clear does the work to rid the small intestine of the bacteria that is causing the gut dysbiosis. It contains a blend of herbal extracts and essential fatty acids to rid the bacteria and promote balanced levels of gut microorganisms in the small intestinal tract and colon.

The Primal Earth Probiotic is custom formulated with a soil-based probiotic specifically designed to repopulate the small intestine with the right bacteria. Most generic probiotics contain lactic acid which can actually contribute to the growth of SIBO. The Primal Earth Probiotic does not have any lactic acid and has a specific design to repopulate the gut with proper bacteria.

SIBO Breakthrough Kit Supplement Benefits

SIBO-Specific Cure

The main and most important benefit of this kit is the specific formulation to cure bacterial overgrowth. It is designed specifically to treat SIBO, unlike other generic probiotics on the market. 

Prevention of Recurrent SIBO

It is also specifically designed to prevent SIBO from recurring. Many people who have struggled with SIBO will generally get it again at some point. By taking this supplement kit, you won’t have to worry as much about recurrence.

Improved Digestive Health

Since about 55% of those with IBS have SIBO, addressing the root cause of IBS symptoms can improve, leading to better digestive health and improved wellness.


SIBO Breakthrough Kit Ingredients

Microb-Clear Ingredients

This product contains the following nutrients:

  • Calcium: Can be commonly malabsorbed in patients with SIBO, and is helpful in supporting the diversity of the gut microbiome.
  • Magnesium: Low intake of magnesium can reduce the diversity of your microbiome and also increase constipation.
  • Zinc: This mineral helps to improve the gut barrier function, reduce inflammation, and promote bowel regularity.
  • Berberine: In one study, this supplement altered the bacteria in the gut and improved the structural function of the microbiome.
  • Caprylic Acid: A type of medium chain triglycerides (a.k.a. MCT oil), this is potentially helpful to increase absorption.
  • Seratio Peptidase: Added to help penetrate the outer coating of bacteria that are sticking to the gut walls and destroy the remnants. It’s a significant addition to the supplement in that it helps to not only get rid of the bacteria, but penetrate it deep enough to get rid of it for good and prevent future SIBO.
  • Black Walnut: Known for its antimicrobial effects, black walnut can be helpful to rid unwanted bacteria.
  • Wormwood: Also known for its antimicrobial effects. It also has the added bonus of reducing inflammation, which is helpful for the gut lining to heal.

Primal Earth Probiotic

Primal Earth Probiotic is designed around the Paleo principle. The belief is that our Paleo ancestors consumed root vegetables from the ground and consumed the organic, rich soil that was full of healthy microorganisms. Our sterile society does not allow us to consume the needed microorganisms found in soil. The probiotics in this product also do not contain lactic acid, which makes SIBO worse and is found in most generic probiotics. Instead, they contain probiotic strains that are specifically used to treat IBS, SIBO, and other major gut health issues:

  • Bacillus coagulans 
  • Bacillus clausii
  • Bacillus subtilis

Does the SIBO Breakthrough Kit Work?

This product is likely to be effective, based on reviews from previous buyers. However, there are no specific studies done on this particular kit that have been documented. Some of the components in the supplements do have research to back their claims to improve gut health symptoms, such as calcium, magnesium, zinc, and the probiotics bacillus coagulans, clausii, and subtilis. 

Claims vs. Reality

The SIBO Breakthrough Kit claims it treats and heals SIBO specifically. Again, there are no documented studies on this particular product line, but there are many good reviews stating the product helped to heal their symptoms for good. 

How Does The SIBO Breakthrough Kit Compare?

Dr. Amy Myers’ SIBO kit is unique in that it combines supplements that work well together. There are not many combination kits like this. However, there are comparable product lines. Priority One has a SIBO product line that is comparable in ingredients. Ortho Spore is another good option but only includes the probiotic blend, not the SIBO support blend.


There is no clinical research on any of these products specifically to test whether they are effective or not. However, they all contain ingredients that have been shown to improve SIBO outcomes including the probiotic bacillus blend, caprylic acid, berberine, and added minerals.


Dr. Amy Myers’ SIBO breakthrough kit is priced at $114.97 for both supplements. In comparison, Priority One, with a purchase of all three SIBO supporting supplements, is around $227. Purchasing individual products (i.e. just the probiotic blend or just the SIBO support blend) varies from $30-$70 per bottle.


Dr. Amy Myers is rated 4.7 out of 5 on the website. There are many positive reviews of the kit, including improved SIBO outcomes and overall improvement in gut health. Priority One is rated around 4.2 out of 5, and Ortho Spore is rated 4.5 out of 5.

Who is the SIBO Breakthrough Kit Best For?

This kit is perfect for anyone who has been officially diagnosed with SIBO, experiences digestive issues (gas, bloating, etc) after meals, has noticed more food sensitivities, has leaky gut, does not tolerate generic probiotics, is following a low FODMAP diet, or is concerned they may have SIBO.

Is the SIBO Breakthrough Kit Safe?

This product does not indicate whether it is third-party tested, which means the ingredients have not been verified for safety. Supplements are not regulated by the Food and Drug Administration, so many companies will hire a third party to test their supplement for safety. 

In the reviews, most buyers are pleased with the results. A few have documented an increase in gut health issues when initially taking the product, but this claim varies. In addition, those who have nut or walnut allergies should err on the side of caution due to the presence of Black Walnut in this product line. Dr. Amy Myers recommends you talk with your doctor before taking this product to ensure no medications or supplements interact.

Where to Buy SIBO Breakthrough Kit

You can purchase the SIBO Breakthrough Kit through the official Amy Myers MD website here.

sibo website

A one-time purchase of the SIBO Breakthrough Kit costs $114.97. They do also offer a subscribe and save option as well, which will save you 15% and lower the price to $97.72.

sibo breakthrough kit

Get up to 15% OFF

SIBO Breakthrough Kit

  • Features two different formulas
  • Ingredients include calcium, magnesium, Bacillus Coagulans, and more
  • Benefits include helping to treat bacterial overgrowth and improving digestive health

SIBO Breakthrough Kit Ratings

This product has an overall rating of 4.7 out of 5, and in reading the reviews from customers is very helpful to improve symptoms of SIBO and reduce onset of future bacterial overgrowth. The ratings show a very positive outcome, even though there are a few who didn’t see a big change in outcome or felt there were some potential GI side effects from taking the supplements.

The Bottom Line: SIBO Breakthrough Kit Review

The SIBO Breakthrough Kit could potentially be a good option for someone who is struggling with recurrent SIBO occurrences, or issues with IBS. Although there is no direct data available on the specific product, it does contain essential nutrients that can help combat SIBO. The price is very reasonable compared to competitors for the bundle. Overall, it is a great option to try if you are ready to heal your gut for good.

Overall Rating:
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Callie Miller, MS, RD, LD, CPT

Callie Miller, MS, RD, LD, CPT is a Registered Dietitian and Certified Personal Trainer with eight years of experience in coaching clients to achieve weight loss, manage chronic disease, and improve sports performance. She received her Bachelor of Science in Dietetics Degree from Idaho State University, and Master of Health Science in Nutrition Degree from Western Carolina University. She has worked in multiple areas including community nutrition programming, clinical nutrition, and private practice.

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