Instaflex Advanced Review – Can This Supplement Give You Joint Pain Relief?

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By Scot Mills

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Instaflex Advanced Review

Instaflex Advanced is a physician-formulated supplement that supports joint health by reducing inflammation and pain.

With a “team” consisting of Chief Medical Advisor David Katz and retired NFL quarterback Doug Flutie, Instaflex is a company bent on keeping your joints healthy and pain-free. It offers the best in all-natural joint care, including pain relief creams and supplements like Instaflex Advanced, designed to keep you and your joints pain-free and moving. 

There are tons of joint supplements out there, from Tropical Oasis Joint Complete Premium to Performance Lab Flex. How do you choose the best one to ensure you get the best value for your money?

In our Instaflex Advanced review, we’ll learn more about this supplement and discuss its benefits, ingredients, and more so you can decide if it is the right choice.

Instaflex Advanced Joint Relief

About Instaflex Advanced

Based on the latest cutting-edge nutritional research, Instaflex Advanced is a doctor-formulated joint supplement containing science-backed ingredients.

It comes in a convenient once-daily capsule, is uniquely (in the world of joint supplements) glucosamine-free, and is backed by a 30-day money-back guarantee.

Instaflex Advanced Joint Relief bottle

Instaflex Advanced Benefits

Provides Significant Relief In As Little As 7-days

Ingredients such as resveratrol, turmeric, Boswellia Serrata Extract, and black pepper fruit extract are potent antioxidants that work immediately to reduce oxidative stress in joints. UC-II also adds collagen to your joint cartilage to keep it smooth and slippery, and hyaluronic acid adds hydration and elasticity to it as well.

Is Free Of Shellfish And Glucosamine

While glucosamine is generally a safe and effective joint care compound, it has side effects for some, and it can be fatal for those allergic to shellfish (which most glucosamine is derived from).

Instaflex Advanced is a safe and effective alternative for people who experience gastric upset, abdominal pain, diarrhea from glucosamine, or those who are allergic to shellfish.

It Frees Up Joints To Restore Pain-free, Flexible Movement

When you reduce joint inflammation and stimulate your body to produce healthy joint cartilage, you get joints that are pain-free, mobile, and have full range of motion. This is excellent news for those suffering from osteoarthritis, which the ingredients in Instaflex Advanced have shown to alleviate the symptoms effectively.

Instaflex Advanced Ingredients

Turmeric Extract

A powerful antioxidant that has been used both medicinally and as a spice throughout history, Instaflex includes 200 mg of Turmeric in its Advanced formula, which provides immense relief from most joint pain caused by inflammation.


A natural plant compound and powerful antioxidant commonly found in red wine and richly colored fruits and nuts, Instaflex includes 100 mg of resveratrol in its formula. Along with its other ingredients, this forms a strong antioxidant force to reduce joint inflammation and keep you moving.

Studies have also shown that Reservatrol supplementation can boost blood flow and cardiovascular health.

Boswellia Serrata Extract

Also known as Indian Frankincense, the 100 mg of Boswellia in Instaflex Advanced contain acids that work to reduce inflammation by relieving the body’s oxidative stress.


Along with its lineup of antioxidant superstars, Instaflex includes 40 mg of UC-II undenatured collagen in its formula to provide healthy construction materials for your joint cartilage. This helps keep your cartilage thick, hydrated, and smooth, promoting joint health and flexibility.

Hyaluronic Acid

Produced naturally in the body to keep connective tissues hydrated and healthy, Instaflex includes 5 mg of hyaluronic acid in its formula that acts as a cushion for the joints, reducing friction and irritation.

Bioperine®-Black Pepper Extract

Along with turmeric, black pepper is a potent antioxidant that has long been used as a spice. Bioperine— AKA Piperine—is the active ingredient in pepper in the form of an extract, which Instaflex includes 5 mg of in their formula.

Instaflex Advanced supplement facts

Does Instaflex Advanced Work?

If you suffer from joint pain related to inflammation or minor cartilage wear, there is a good chance this product will work well for you. That’s because, along with all its ingredients being backed by science, Instaflex Advanced takes a 2-pronged approach to joint care: potent antioxidants to relieve symptoms of oxidative stress and compounds to help rebuild and hydrate joint cartilage to keep it fluid and healthy.

So yes, this product should work for most.

Is Instaflex Advanced Good For Arthritis?

Instaflex Advanced contains anti-inflammatory ingredients that may help alleviate the symptoms of arthritis, including joint pain and swelling.

Who Is Instaflex Advanced Best For?

Anyone experiencing painful, creaking, achy joints should see improvement using this product. This includes those experiencing osteoarthritis and those experiencing normal age-related joint wear and tear.

The product is also gluten-free and free of shellfish, making it ideal for anyone with allergies to these compounds.

Instaflex Advanced Joint Relief supplement for joint pain

Claims vs. Reality

So far as whether or not Instaflex lives up to its claims, there is no reason to doubt them. The product contains scientifically proven ingredients to reduce inflammation, restore cartilage, and keep your joints working smoothly and healthily.

The product is also glucosamine-free for those allergic to glucosamine or shellfish.

On a side note, while the product doesn’t claim to be “all-natural,” we nonetheless question the inclusion of a substance such as “FD&C Blue #1” as part of the gelatin capsule. While FD&C Blue #1 isn’t a significant health concern, seeing such an unnecessary synthetic ingredient in a product meant to benefit natural health is disconcerting.

Is Instaflex Advanced Safe?

As long as the product is used as directed and the user has no allergies to its ingredients, the only known side effects are more unrestrained, pain-free joint movement, and reduced inflammation.

Where To Buy Instaflex Advanced

At $69.99 for a 1-month supply, Instaflex Advanced carries a premium price. Granted, the ingredients live up to the standards one would expect of a pill costing them over $2 per day. There is also the added convenience of it being a simple one-a-day capsule, though the ingredients on their own could likely be gathered for much less.

You can try the Instaflex Advanced free of charge for 14-days before committing to it, which should be enough time to evaluate your results. Beyond that, there are no volume discounts or other offers, so the company is confident in its product’s worth.

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It is also widely available through most online brick-and-mortar retailers selling natural supplements, including Amazon, Vitamin Shoppe, GNC, and many independent stores.

Our Verdict

Instaflex Advanced contains science-backed ingredients that help relieve inflammation and support joint health and mobility. It has many positive user reviews that attest to its efficacy. However, a significant pain point for some was the price, which we think may be worth it given its effectiveness.

Overall, Instaflex Advanced seems like it could be “it” for you. Although similar supplements may be available on the market, many users have experienced relief from using Instaflex Advanced, and so could you.

Overall Rating:
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Scot Mills

Scot Mills is a nutrition writer who uses his unique skills and passions for natural products to share his research with others. Along with over twenty-years of experience working in natural industry sales, Scot graduated at the top of his class as a business major, and is a member of the Sigma Beta Delta honors society for his outstanding scholastic achievements. Scot specializes in using the latest scientific research to review supplements objectively. When he isn’t writing or hitting the gym, Scot can be found enjoying nature on epic trail runs, hikes, and mountain bike rides.