Research-Based

Best Choline Supplements

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By Alexa DaFonte

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Best Choline Supplements

Our bodies require numerous nutrients and vitamins to maintain optimal health. We need Vitamin D, Vitamin C, fiber, and many others. Another crucial nutrient you shouldn’t overlook is choline. Considered an essential nutrient, choline must be obtained through our diets since our liver produces only minimal amounts. What makes choline unique is that it’s neither a vitamin nor a mineral, yet remains vital for our bodies. Choline maintains nervous system health, supports healthy metabolism, synthesizes DNA, and helps produce cell messengers.

While choline deficiency is uncommon, insufficient levels can severely impact liver health, cause muscle damage, and create pregnancy complications. Choline is particularly important for reducing heart disease risk. Given choline’s numerous benefits in the body, choline supplements have gained significant popularity. So, what are the best choline supplements? Let’s explore!

Choline Supplements

What Are the Different Types Of Choline Supplements?

The most common supplemental forms include choline chloride, Alpha-GPC, betaine, and CDP-choline (citicoline). CDP-choline and Alpha-GPC are widely used and potentially more effective since they offer superior absorption. Our bodies respond to these two choline supplements similarly to dietary choline sources.

CDP-choline (citicoline) delivers substantial choline content and helps transport dopamine, the neurotransmitter responsible for positive emotions. Citicoline may specifically help improve memory deficits while enhancing focus and concentration.

Alpha-GPC increases production of acetylcholine, the neurotransmitter responsible for muscle memory that enables proper muscle movement. It may also trigger dopamine release in the brain. Alpha-GPC is known to enhance cognition, increase strength, and aid muscle recovery, particularly after workouts. Alpha-GPC appears to have a slight advantage in boosting choline levels and associated benefits, though more research is needed.

Food additives containing choline also exist, with soy lecithin being particularly popular. You can purchase lecithin as a supplement, and it has proven effective in the body.

Choline DIAGRAM

Choline Supplement Benefits

Choline is an incredibly vital nutrient our body requires. It serves as a component of acetylcholine, a neurotransmitter essential for brain function. Choline also plays a key role in cellular growth and metabolism. Here are the primary functions and benefits of choline:

  • Healthy metabolism
  • Cellular growth
  • DNA synthesis
  • Production of cell messengers
  • Maintains and promotes nervous system health
  • Produces acetylcholine, a neurotransmitter
  • Reduces the risk of heart disease
  • Supports liver health
  • Supports a healthy pregnancy
  • Reduces the risk of birth defects among babies, including neural tube defects
  • Supports muscle growth
  • Promotes memory function
  • Plays a role in our mood

Many people take choline supplements to prevent insufficient levels and amplify these benefits. Notable advantages of supplemental choline include enhanced memory and cognition, heart health protection, metabolic boost, and reduced pregnancy complications.

Benefits Of Choline Supplements

Should I Take Choline Supplements?

While we require choline from dietary sources, certain at-risk populations may need choline supplements. The following groups face increased risk of choline deficiency (though rare):

  • Postmenopausal women
  • Pregnant women
  • Athletes undergoing endurance training (marathon runners)
  • Individuals who consume a lot of alcohol

Choline requirements vary by age, gender, and pregnancy status. If you require supplemental choline, consult a doctor first. Additionally, excessive choline can cause hypotension, sweating, vomiting, and liver toxicity.

Choline Supplement Pills

Do Choline Supplements Work?

Though choline requirements vary based on different factors, we generally don’t need large amounts. Even so, many people don’t get adequate choline and require supplementation, particularly at-risk populations like pregnant women.

Researchers have deemed choline relatively safe in supplemental form and proven it beneficial. One of the greatest advantages for pregnant women is significantly reducing the likelihood of neural tube defects in babies. However, some research shows it’s unsafe in large quantities, as choline toxicity can cause vomiting and fishy body odor.

Choline functions similarly to B vitamins in our bodies. While choline is important, this doesn’t mean everyone should take large doses. Consulting your doctor beforehand is essential, especially given toxicity risks and limited research.

The Best Choline Supplements

NOW Supplements Alpha-GPC

NOW Supplements Alpha-GPC

This highly-rated supplement contains 300 mg of Alpha-GPC, the most bioavailable choline form. The Alpha-GPC is derived from soy lecithin.

Jarrow Formulas Citicoline CDP Choline

Jarrow Formulas Citicoline CDP Choline

This product contains 250 mg of CDP choline, another highly bioavailable choline form. While excellently rated, it comes at a higher price point than other choline supplement options.

Nested Naturals Choline Bitartrate

Nested Naturals Choline Bitartrate

This product delivers 500 mg of choline bitartrate. Highly rated and an excellent vegan option, the only drawback is that this form may not be as bioavailable as others.

Choline Supplement Alternatives

Choline appears in many dietary sources that can provide adequate levels of this nutrient. Here are excellent dietary choline sources:

  • Beef liver
  • Eggs
  • Cod
  • Salmon
  • Cauliflower
  • Soybeans
  • Nuts and seeds
  • Whole grains (quinoa, rice)
  • Most beef
  • Most fish

Incorporating these choline sources into your diet will help maintain adequate choline levels while providing other essential vitamins and minerals—an added advantage of dietary sources over supplements.

Choline And Your Health

Choline is an essential nutrient that your body and nervous system depend on. Though choline deficiencies are rare, many people don’t obtain sufficient amounts through dietary sources. Certain at-risk groups, like pregnant women, require higher levels and may need supplemental choline.

Many choline supplements are available, but those containing Alpha-GPC or citicoline are superior due to better bioavailability. Ensuring adequate choline intake helps protect your brain, nervous system, heart, and muscles. Always consult your doctor before taking choline supplements.

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Alexa DaFonte

With a degree in Nutrition and Health Sciences from the University of Massachusetts Amherst, Alexa brings a vast knowledge of nutritional sciences, especially as it intersects with modern health and wellness. Due to her passion for a healthy lifestyle, she enjoys spreading awareness of the science behind many of her nutrition practices.