Protandim Nrf2 Synergizer Review – An Antioxidant Supplement By LifeVantage

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By Ryan Brennan

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

ProtandimNrf2Synergizer - Review

About Protandim Nrf2 Synergizer

Our bodies have an extremely intricate way of keeping themselves healthy, even when threats arrive. While free radicals are naturally produced in the body and are utilized appropriately, too many of these unstable atoms can cause short-term or long-term damage. 

Coincidentally, our bodies will also produce antioxidants. These are molecules stabilize free radicals by donating an electron. When the number of free radicals in the body exceeds the number of antioxidants, your body will experience oxidative stress — which are those short-term and long-term health issues we were talking about. 

The free radicals will eventually start to attack the fatty tissue, proteins, and DNA in your body. Oxidative stress has been linked to various health concerns like diabetes, inflammation, heart disease, high blood pressure, atherosclerosis, cancer, and neurodegenerative diseases. Of all those issues to worry about, most people’s interest lies in its effect on aging. 

Believe it or not, the oxidative stress theory for aging has been around for nearly 70 years. Still, researchers have a lot to understand about oxidative stress and how we can control it more efficiently. One supplement claiming to help control oxidative stress is Protandim Nrf2 Synergizer. Let’s see how this supplement measures up.

What Is Protandim Nrf2 Synergizer?

Protandim Nrf2 Synergizer is a supplement manufactured by LifeVantage. It was designed to target anyone who experiences oxidative stress by increasing the body’s supply of antioxidants. It’ll do this by activating the Nrf2 protein, which plays a vital role in antioxidant production. 

Protandim Nrf2 Synergizer

With a clearer pathway for antioxidants, the number of free radicals will start to decrease and eventually stabilize. In fact, Protandim Nrf2 Synergizer claims to reduce oxidative stress by up to 40% in 30 days — a claim with a clinical study to back it. 

Let’s take a look at some of the other claims made by LifeVantage:

  1. Aids the body in detoxifying genes
  2. Reduces cellular stress 
  3. Helps produce enzymes that can eliminate up to 1,000,000 free radicals
  4. Regulates survival genes
  5. Improves the body’s ability to repair or rejuvenate cells
  6. Increases superoxide dismutase levels by 30% and catalase by 54%

Utilizing 100% vegetarian ingredients, Protandim Nrf2 Synergizer will help your body fight oxidative stress — and win!

Ingredients Of Protandim Nrf2 Synergizer

Of course, we’ll have to take a look at the ingredients before doubling down on Protandim Nrf2 Synergizer. Supplement companies can be highly deceiving and even when you think they’re being transparent, they can still be hiding something. 

Let’s go through every ingredient LifeVantage uses in Protandim Nrf2 Synergizer and find out how good this supplement really is.

Turmeric Root

If you’re looking for a powerful nutrient to add in your daily diet, turmeric is the way to go. Known as one of the most effective nutrients available, turmeric has a mountain of evidence supporting it and has been used as a traditional medicine for over 4,000 years. 

You might know turmeric as what gives curry the yellow color, but it’s known for much more than just that. It is a powerful antioxidant and holds anti-inflammatory properties. It can also improve brain function, lower risk of heart disease, and help prevent cancer or a variety of neurodegenerative diseases. 

Protandim Nrf2 Synergizer - Turmeric Root

Recommended Intake: 250-500mg daily

Green Tea

If you’ve never had a cup of green tea before, you’re missing out on one of the healthiest beverages available. It’s packed with a lot of antioxidants and can help lower the risk of cardiovascular disease, enhance brain function, and protect your body from cancer. 

It’s high in polyphenols, contains epigallocatechin-3-gallate, and a variety of minerals. Green tea can even help prevent aging and bad breath. 

Recommended Intake: 250-500mg daily

Bacopa Monnieri

A plant heavily used in traditional Ayurvedic medicine, Bacopa Monnieri is one of the most powerful and effective nootropics on the market today. This is all due to bacosides, a powerful class of compounds, found in the plant. 

Bacopa Monnieri is known to contain a lot of antioxidants, while also reducing inflammation, boosting brain function, managing ADHD symptoms, and preventing anxiety or stress.

Recommended Intake: 300-500mg daily

Milk Thistle

Silybum Marianum, commonly referred to as the milk thistle plant, has been a natural remedy for thousands of years. The active ingredients belong to a class of compounds called silymarin. One of the main uses of the milk thistle plant is for its antioxidant, antiviral, anti-inflammatory properties. 

Milk thistle will also play a major role in protecting the liver from damage, reduce age-related decline, protect your bones, and can boost milk production in females. 

Protandim Nrf2 Synergizer - Milk Thistle

Recommended Intake: 300-400mg daily


Here’s another ancient medicinal herb that’s officially classified as an adaptogen, which helps your body manage and move past stress. It is known to help improve brain function, memory, lower cholesterol, increase muscle mass, reduce depression symptoms, boost testosterone, reduce cortisol levels, and reduce blood sugar. 

Research has proven it to be safe for most adults, but should be avoided if you are suffering from an autoimmune disease, thyroid disease, or are pregnant. 

Recommended Intake: 400-500mg daily

Dosage, Packaging, & Pricing For Protandim Nrf2 Synergizer

Protandim Nrf2 Synergizer comes in an attractive blue bottle, about the size of your typical pill bottle. It’ll have a gray top and gray lettering, but minimal text on the label. They don’t waste space with those precious claims and guarantees, instead letting their product speak for itself. 

They do give us the ingredients on the label, but they aren’t exactly transparent on the dosage of each ingredient. Instead of giving you exact numbers for each, they display their ingredients as a proprietary blend totaling 675mg per caplet. It also contains 77mg of calcium.

Each bottle will come with 30 caplets, intended to be taken once per day. It’s suggested to take by mouth with food. You will have two options when purchasing — a single bottle for $59.99 or a three-pack for $150.99 (about $10 less per bottle). 

Protandim Nrf2 Synergizer - Packaging

Pros vs. Cons

Every supplement you come across on the market today will come with pros and cons. Some might be more prominent than others, which is why it’s always important to do your research before making a purchase. 

Let’s see what the pros and cons look like for Protandim Nrf2 Synergizer.


  • Clinical trial proved a 40% reduction in oxidative stress within 30 days
  • All ingredients come with evidence to back it up
  • Will do what it says it does
  • Bacopa Monnieri and Ashwagandha are extremely popular plants in supplements
  • Every ingredient provides antioxidants for the body
  • Acts as an Nrf2 activator, reducing oxidative stress
  • NSF and BCSG-certified
  • 100% Vegetarian
  • Free of Gluten, Wheat, Dairy, Gelatin and Yeast


  • Not yet rated by the FDA
  • Rather expensive for a month’s supply
  • Proprietary blend doesn’t tell you how much of each ingredient
  • Proprietary blend is a rather small dosage for all 5 ingredients to begin with

Protandim Nrf2 Synergizer Claims vs. Reality

One of the biggest claims this product makes is that it will effectively help reduce up to 40% of oxidative stress within 30 days of daily use. The good news is they have a clinical trial that supports that claim, including peer-reviewed studies conducted by the likes of Harvard, Ohio State, the American Journal of Physiology and many more. 

Looking at the list of ingredients, it’s pretty clear why it’s been so beneficial to so many people. They use highly-researched ingredients with a large amount of supporting evidence backing them. Unfortunately, it’s tough to fully analyze the effectiveness of Protandim Nrf2 Synergizer without knowing how much of each ingredient they used. 

While it won’t harm you or cause any major side effects, there’s a good chance it isn’t packing enough of the right ingredients to work for everyone. 

Final Verdict For Protandim Nrf2 Synergizer

There are plenty of ways to reduce oxidative stress in the body. There are various fruits and vegetables that can help boost the production of antioxidants like berries, cherries, olives, tomatoes, citrus fruits, prunes, carrots, broccoli, and dark leafy greens. 

In addition to that, making smarter and healthier lifestyle choices can reduce oxidative stress in the body. A regular exercise routine, no smoking, being cautious with cleaning chemicals, and wearing sunscreen can help. 

Still, many people will struggle with oxidative stress when free radicals start outnumbering the antioxidants in your body. Having a daily supplement to take will help your body ward off any imbalances in your cells — even on those days you can’t find the time to exercise. 

With Protandim Nrf2 Synergizer, you’ll definitely get a product with the right ingredients. Unfortunately, there’s a chance it isn’t as effective for everyone. There’s likely a reason they aren’t showing us the exact dosages. 

Overall, Protandim Nrf2 Synergizer is a good product that shouldn’t cause harm. If it doesn’t seem to help after 30 days, there’s a good chance it’s just not powerful enough.

Overall Rating:
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Ryan Brennan

Ryan Brennan is a health and fitness writer with both personal and professional experience in the field. His passion for nutrition stems from personal experiences dealing with malnutrition, low energy, and other health complications. Through research and experimentation, Ryan was able to overcome these issues and take control of his health. He now aims to help others do the same. Ryan has been writing about nutrition, fitness, and supplementation for the past 7 years. He also has experience in the field, serving as the manager of a high-end fitness facility in Las Vegas, NV where he currently resides.