Research-Based

OxySpark Review – How Effective is This Nitric Oxide Booster?

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By Leslie Waterson

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

OxySpark-Review

OxySpark is a powdered nutritional supplement designed to enhance nitric oxide production, alongside several other claimed benefits. Available for the past few years, the product is owned by SyberVision, an IT education company. The owner, with a background in psychology and communications, developed this supplement specifically for Baby Boomers. According to their website, the product was on back-order but resumed shipping on January 30, 2020.

OxySpark Supplement-Product

Benefits of OxySpark

Widen Arteries for Increased Circulation

OxySpark’s ingredients have demonstrated the ability to boost nitric oxide production. This crucial gas molecule regulates circulation by relaxing the smooth muscle surrounding blood vessels. Since our bodies produce less nitric oxide as we age, restoring optimal levels through supplementation can deliver significant benefits.

Reverse Cardiovascular Disease

This represents an extremely bold—and potentially dangerous—claim. While nitric oxide influences blood pressure, and blood pressure affects cardiovascular disease, this doesn’t automatically mean OxySpark can reverse cardiovascular conditions. The FDA explicitly prohibits supplement companies from making disease-specific claims about their products.

Reverse Kidney Disease & Failure

Like the previous claim, this is an extraordinarily serious assertion. While certain ingredients might address underlying factors associated with kidney disease, such research remains in its preliminary stages.

Manage Diabetes by Regulating Insulin

Aside from the magnesium content in OxySpark, no ingredients appear to directly influence insulin secretion or activity. This represents another substantial claim for a nutritional supplement to make.

OxySpark Ingredients

OxySpark Supplement Facts

Multivitamin/Multimineral Backbone

OxySpark features a modest multivitamin/multimineral foundation—though this isn’t necessarily detrimental. The formula includes valuable vitamins like D3, K2, and B-complex, plus essential minerals including magnesium, zinc, and selenium. These nutrients are reasonably dosed, except magnesium, which falls on the low side. While these nutrients offer benefits, they don’t directly support OxySpark’s primary claims. Since the product aims to enhance nitric oxide production and cardiovascular function, it could be more cost-effective and equally potent without these added vitamins and minerals.

Proprietary Nitric Oxide/Vasodilator/Antioxidant Complex

L-Citrulline

This amino acid has become essential in nitric oxide boosting supplements. Although arginine is necessary for nitric oxide production, our liver restricts absorption. Citrulline bypasses this limitation since our bodies absorb it virtually without restriction. This proves advantageous because citrulline converts readily to arginine, subsequently boosting nitric oxide. Interestingly, citrulline supplementation elevates blood arginine levels more effectively than direct arginine supplementation. The recommended citrulline dose typically ranges around 3g or 3,000mg daily. However, OxySpark’s proprietary blend makes determining the exact dose impossible.

ViNitrox (grape & apple polyphenol concentrate)

Polyphenols from grapes and apples have proven effective for vasodilation. These compounds work through multiple mechanisms: reducing inflammation and decreasing foam cell formation plus stiffness in the intima (blood vessel region). This enhances vessel elasticity, enabling superior vasodilation. However, polyphenol quality varies significantly. OxySpark would benefit from specifying the polyphenol types in this ingredient. Without dosage information, comparing against ViNitrox clinical trials becomes impossible.

Beet Root Extract

Beets have traditionally supported heart and cardiovascular health. This root vegetable contains concentrated nitrites, which convert easily into nitric oxide. Unfortunately, minimal research examines beetroot powder specifically—most recommendations stem from beetroot juice studies. OxySpark fails to specify nitrite concentrations in their beetroot powder or provide dosage information.

CoQ10

Coenzyme Q10 ranks among our most potent antioxidants. While our bodies naturally produce it, production declines with age. CoQ10 primarily functions in mitochondria, facilitating energy (ATP) creation. Physicians typically recommend 100-300mg of CoQ10 for cardiovascular support—based on liquid-gel capsules. Since CoQ10 is fat-soluble, powder forms like OxySpark’s offer significantly reduced absorption. Additionally, powdered CoQ10 costs considerably more. CoQ10 supplementation proves more effective in standalone liquid-gel capsules.

AstraGin (Astragulus + Panax notoginseng)

AstraGin is a proprietary ingredient combining astragalus and ginseng. Preliminary manufacturer evidence suggests this blend enhances absorption of other ingredients, specifically claiming a 45% increase in citrulline absorption. However, the research appears conducted through in vitro methods—studying cells in petri dishes. Petri dish environments differ vastly from our complex digestive systems. While promising, these claims lack significance without human trials or animal model studies.

Enzogenol (New Zealand pine tree extract)

New Zealand pine tree contains antioxidant compounds called proanthocyanidins. These antioxidants reduce inflammation by neutralizing free radical damage, resulting in improved blood pressure control. Enzogenol offers the additional benefit of reducing DNA damage in older adults. Like other ingredients in OxySpark’s proprietary blend, the exact amount included remains unknown.

Trace Mineral Complex

The trace mineral complex contents remain unspecified. While some trace minerals appear in the supplement facts panel, it’s unclear whether these constitute the complex or represent additional minerals. This ingredient creates unnecessary confusion.

How Does OxySpark Work?

How Does OxySpark Work

OxySpark incorporates several key ingredients commonly found in nitric oxide supplements. However, the product doesn’t position itself merely as a vasodilator. Their website makes extraordinarily bold claims—even beyond those listed above. This formulation cannot possibly deliver everything they promise. It may enhance nitric oxide and help some individuals with blood pressure or circulation issues.

Claims vs. Reality

OxySpark makes bold claims, most of which violate FDA regulations. The FDA states directly: “… the dietary supplement product is not intended to ‘diagnose, treat, cure or prevent any disease,’ only a drug can legally make such a claim.” For more information, review the Structure/Function Claims link below.

At best, this product may provide modest improvements for blood pressure and circulation concerns. Despite claiming to “Manage Diabetes by Regulating Insulin,” few ingredients in the formulation have undergone relevant research. While OxySpark is unlikely to cause harm, it should never replace prescribed medications.

Safety

Consult your physician before taking this product. Since OxySpark may affect blood pressure and targets those with cardiovascular concerns, combining it with blood pressure or heart medications could produce adverse effects.

Where to Buy OxySpark

OxySpark Supplement Website

OxySpark $79.95

Studies

Foods Containing L-Citrulline 

Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials 

Custom Formulation Supplement Manufacturer Private Label NutraCap Labs 

Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects – ScienceDirect 

Structure/Function Claims

Overall Rating:
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Leslie Waterson

Leslie has been passionately involved in the health and fitness industries for over a decade. She is constantly reviewing the latest scientific research and studies in order to take a research-backed approach to lifestyle optimization. Her main areas of interest include nutrition and supplementation. Leslie shares her findings on Fitness Clone to help other health enthusiasts choose the products and routines that will help them achieve their goals.

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