Metabolic Advanced Review – Is This Gundry MD Supplement Worth Using?

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By Thomas Youngerman

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Metabolic Advanced Review

Having a fast metabolism is great, as it helps you keep your weight lower, which benefits your overall health. Unfortunately, there are many who simply do not have that type of metabolism, and that can lead to health issues, such as becoming overweight. That is why many are now turning to metabolism-enhancing supplements.

One of these is the Metabolic Advanced supplement from Gundry MD. This product aims to promote a healthy metabolism leading to a variety of health benefits.

healthy metabolism

But what is this “healthy metabolism” Dr. Gundry promises? In this Metabolic Advanced review, we will not only do a deep dive into what this supplement can offer, but we will also cover metabolic rate to help you further your understanding. Ready to find out if Metabolic Advanced can provide the benefits you are looking for? Let us dive in!

Metabolic Advanced Review: Key Facts

BenefitsDigestive Health, Energy, Weight Loss, Glucose Management
IngredientsChromax, BioPerine, Zinc Citrate, Turmeric, and more
DiscountsUp to 16% Off
CompanyGundry MD

What Exactly Is Metabolism?

Before diving into our Metabolic Advanced review, we think it’s important that readers have a basic understanding of how metabolism works. Understanding this process will help you better understand how Gundry MD’s Metabolic Advanced supplement works and whether or not it is a good fit for you.

Let’s get to it.

Research metabolism and you will see tons of articles and ads that promise you can manipulate your metabolism with a new diet, pill, exercise program, green tea, or more coffee. That is because “metabolic rate” is often used interchangeably with the word metabolism. Metabolism is a process, while the metabolic rate is one aspect of that process. 

Every cell in your body requires energy to fuel your body’s internal functions, build and repair tissue, deliver nutrients to your brain, or pump oxygen from your lungs and heart to your muscles. We source that energy from the foods we eat, and your metabolism converts those calories to energy.

Metabolism refers to all the chemical processes in your body that keep you alive and functioning. When working properly, your metabolism keeps the body’s systems functioning normally, in a process called homeostasis.

This complex system is divided into two parts, one that breaks down nutrients from our food known as catabolism, and one that builds and repairs our body called anabolism. 

Metabolism-breaks down nutrients from our food


This process breaks down the foods we digest into smaller molecules that either release energy or are used as the building blocks for growth and repair. Carbohydrate energy metabolism is the catabolic process that raises blood glucose levels but also provides energy to your body’s cells and tissues. 


This is the part of the metabolism in which our body uses the energy from food for the repair of tissues or storage. 

When you consume more food than your body requires for energy and/or anabolism, it is stored as fat. This leads us to the discussion of the metabolic rate, the aspect of metabolism concerned with the number of calories you burn.

Metabolic Rate Explained

Many things affect your metabolic rate. These include the rate at which you burn calories, including gender, body mass index, age (your metabolism declines as you age), height, muscle mass (lean muscle burns more calories than fat), body size, hormonal factors, and genetic predisposition.

There are four key components to your metabolic rate: 

  • Resting or basal metabolic rate (RMR or BMR)  – The number of calories you expend for essential life-sustaining functions in the absence of exercise.  BMR is 60% – 70% of your total calorie expenditure per day. 
  • Thermic effect of food (TEF) – The calories that are required to digest, absorb, and process the nutrients in your food. TEF is typically 10% of your daily calories burned. 
  • Exercise – The number of calories you burn through exercise or physical activity. 
  • Non-exercise activity thermogenesis (NEAT) – The calories you burn through non-exercise activities, such as household chores. Normally, NEAT and exercise represent 20% – 30% of your calories expended. For very active people, this can be as much as 50%. 

Those articles and ads we referenced earlier are primarily concerned with increasing your metabolic rate to burn more calories – the more calories you burn, the easier it is to lose weight and keep it off. 


Metabolic Issues 

You might have heard how unhealthy food cravings, high body mass index (BMI), lack of insulin sensitivity, and weight gain affect you.

Metabolic syndrome is a combination of factors that leads to dysregulation in your metabolism.

This condition is often connected to type 2 diabetes mellitus, heart disease, and high cholesterol levels. 

Metabolic syndrome interrupts your body’s ability to utilize glucose properly, which leads to problems with blood clotting, low energy levels, and increasing blood sugar levels. This syndrome is reversible with good lifestyle choices, diet, and exercise. Gundry MD Metabolic Advanced can also help in treating metabolic syndrome and aiding weight loss. 

Metabolism may also slow down for a variety of other reasons as well. Metabolic slowdown refers to a decline in your metabolic rate, potentially caused by several factors:

  • Age-Related – As we age, most people become less active, experiencing a reduction in muscle mass (sarcopenia). There is also natural aging of your metabolic processes as well as lower energy levels. 
  • Dieting – Consuming too few calories can actually cause a metabolic slowdown and results in even fewer energy levels. 
  • Insufficient Protein Intake
  • Poor Sleep Habits
  • Lack of Exercise— Someone who does not exercise is more prone to diabetes, heart disease, and weight gain. 

With that said, let’s take a closer look at Metabolic Advanced to determine if it can help you solve metabolic issues and improve your health.

About Gundry MD

Metabolic Advanced is created by Gundry MD.

Gundry MD was founded by Dr. Steven Gundry, one of the world’s pre-eminent experts in heart surgery, inventor, author, scientist, and digestive health expert. His New York Times best-selling books include Dr. Gundry’s Diet Evolution, The Plant Paradox, and The Plant Paradox Cookbook.

Gundry MD

The company’s reason for being is

 “To dramatically improve human health, happiness, and longevity through a unique vision of diet and nutrition.”

The Gundry MD company is primarily an online presence that markets dietary supplements focusing on digestive health, the microbiome, and the immune system.

All Gundry MD products are doctor-formulated and made in the U.S. in a certified cGMP (current Good Manufacturing Practices) facility. To further ensure the quality and purity of its products, Gundry has each product tested by an independent third-party facility. 

Metabolic Advanced, the subject of this review, like most Gundry MD products, features all-natural ingredients and contains no artificial sugars. Transparency in labeling is evident. There are no proprietary blends, and each component is on the supplement facts panel with its appropriate dosage.

The company also frequently formulates with patented and trademarked ingredients, clinically proven for effectiveness. There are two trademarked compounds in Metabolic Advanced. 

Each of these go-to-market strategies is a hallmark of best-in-class companies in the dietary supplement space. 

Metabolic Advanced Ingredients

Metabolic Advanced’s formula contains seven natural ingredients known to address digestive health, including two trademarked proprietary ingredients. Our research and editorial team will take a look at how effective Gundry MD and this dietary supplement designed to boost metabolism really are. 

GundryMD Metabolic Advanced Supplement Facts

If you’re not interested in the science behind the formulation, feel free to skip to the next section of our Metabolic Advanced review where we discuss the product benefits (and whether or not it works).

Chromax® (Chromium Picolinate) from Nutrition 21, LLC 100 mcg

Nutrition 21 has performed 35 human clinical studies (more than 100 research studies in total) on Chromax® to support structure-function claims for weight management, appetite control, body composition, glucose metabolism, and energy support. In sports nutrition and weight loss supplements, the ingredient is used extensively (in more than 75 brands).

In reviewing these studies, we observed that the typical dosage was 200 mcg to 600 mcg, so we were a bit disappointed in the 100 mcg in Metabolic Advanced. These dosages are used to improve thyroid function and insulin resistance. Other claims, like reducing unhealthy food cravings are not necessarily proven. 

Chromax® is known for its superior bioavailability, so perhaps, in combination with the other compounds in Metabolic Advanced, the under-dosing is acceptable.

BioPerine® (Black Pepper Fruit Extract) 10 mg

This ingredient comes from Sabinsa Corporation. A prevalent ingredient in dietary supplements, BioPerine is used to increase the absorption and bioavailability of the other active compounds.

10 mg is the standard dosage for BioPerine in most supplements. Clinical studies by Sabinsa range from 5 mg to 20 mg. Metabolic Advanced adds enough black pepper fruit extract in its dietary supplement to make it more effective. 

Zinc Citrate 30 mg

Zinc is an essential mineral that may enhance immune function and stabilize blood sugar levels in addition to other health benefits.

If you are looking for healthy glucose metabolism and even weight loss, having enough zinc in your diet is always beneficial. 

Selenium 70 mcg

Selenium is another essential mineral that must be obtained through the diet. It also happens to be a potent antioxidant. Selenium boosts your immune system by reducing oxidative stress and inflammation.

Cinnamon Bark 250 mg

The delicious cinnamon spice has been valued for its medicinal properties for thousands of years. Cinnamon bark is loaded with highly potent polyphenol antioxidants, which have an anti-inflammatory effect. In the Metabolic Advanced formulation, the role of cinnamon bark is to regulate blood sugar levels.

Berberine HCI 250 mg

Berberine has been part of Ayurvedic and Chinese medicine throughout history. This alkaloid compound has many health benefits and treats inflammation, high blood pressure, obesity, and even types of cancer.

Turmeric Root Extract 100 mg

Curcumin, the main active ingredient in turmeric, is a powerful antioxidant and anti-inflammatory. One of today’s most popular supplement ingredients, you will find turmeric in everything from weight management to joint support and cognition products. 

GundryMD Metabolic Advanced

Metabolic Advanced Benefits

Ironically, Dr. Gundry downplays weight management, lean body mass, or fat-burning as benefits of Metabolic Advanced. He does mention in an FAQ segment the potential to slim your waist.

However, the doctor focuses on positioning the product as designed to “support a healthy metabolism, which can set off a chain of additional health benefits, helping you improve your overall health and wellness.”

Below are some of the beneficial metabolic effects that Gundry MD Metabolic Advanced has to offer. 

Increased Energy 

The ingredients in the Metabolic Advanced supplement are meant to improve your metabolism and to do this, they also improve energy levels. 

Metabolic Advanced contains zinc citrate and chromium, which are both known for their enhanced insulin sensitivity properties. This effect results in better utilization of nutrients, and thus more energy. 

Healthy Digestion 

Part of having a good metabolism is that you do not feel as though your body is not digesting well. The ingredients in Metabolic Advanced all help move things along and create a healthier gut. 

Weight Loss and Glucose Management 

Metabolic Advanced is meant to help control food cravings, but might also lead to weight loss. You can also take this supplement to improve your insulin sensitivity and lower blood sugar levels. Chromium picolinate, zinc citrate, and turmeric root extract all improve your glucose metabolism. 

Furthermore, managing your weight and glucose levels will also protect your heart health and prevent other chronic diseases, such as diabetes. 

Less Inflammation 

Treating inflammation is one of the benefits of Metabolic Advanced. Turmeric root extract is regarded as one of the best anti-inflammatory agents out there, and having black pepper fruit extract in this supplement will also help reduce your inflammation and pain. 

Working Out

Recommended Dosage

The company recommends two capsules twice per day, with your largest meals. Note: given the product’s 120 capsules per bottle, this equates to a thirty-day supply.

How Does Metabolic Advanced Perform?

The most notable benefits of Metabolic Advanced are the increased energy you feel and the absence of brain fog throughout the day. Even though weight management is not a highly touted benefit, the inclusion of Chromax® in the formulation will help some people trim their waistline somewhat. 

Most Metabolic Advanced customer reviews showed that clients are satisfied with their product, particularly because of more energy, slight weight loss, and better GI habits. 

Is Metabolic Advanced Safe?

Metabolic Advanced is generally considered safe for healthy adults with no pre-existing blood sugar conditions. In addition, the company reports no adverse reactions.

However, its various ingredients, particularly berberine, may cause digestive issues, such as an upset stomach, constipation, or nausea.

Before adding any new supplement to your regimen, we recommend consulting with your licensed healthcare provider. 

Where to Buy Metabolic Advanced

You can buy Metabolic Advanced directly from the official Gundry MD website here. Each bottle of Metabolic Advanced contains 120-capsules, good for 60 servings or 30 days.

GundryMD Metabolic Advanced Website

Gundry MD offers Metabolic Advanced in three sizes and pricing options, with savings for purchasing additional bottles. Below we will detail the pricing and savings offered by Gundry MD.

Metabolic Advanced Pricing:

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Additionally, members in the Gundry MD VIP program get up to 60% off retail with a subscription, free shipping, and priority handling – reducing the cost to approximately $30.00 per bottle

Realizing each person is unique and responds differently to ingredients, Gundry offers a ninety-day money-back guarantee to anyone not satisfied with their purchase. 

In Summary: Metabolic Advanced Review

We admire Dr. Gundry’s credentials and acknowledge his expertise in the world of digestive health, the microbiome, and the immune system.

The formula he created for Metabolic Advanced comprises clinically tested ingredients, proven effective in combatting oxidative stress and inflammation and providing more energy. The corporate philosophies are spot on with their manufacturing certifications, third-party testing, label transparency, patented ingredients, and money-back guarantee.

If you feel like adding a new supplement to boost energy levels or help get blood sugar levels in the normal range, then Gundry MD Metabolic Advanced is something to try. It also helps to know that your money is safe with their 90-day money-back guarantee. 

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