LiverMD Review – Will This 1MD Supplement Support Your Liver Health?

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


The liver plays a crucial role in cleansing your body from harmful and foreign particles and is vital for overall health. Therefore, taking care of your liver should be one of your main priorities if you want to live a healthy life.

Aside from living a healthy lifestyle – that is, eating a proper diet, working out regularly, getting enough sleep, and managing your stress properly – taking dietary supplements will help keep your liver healthy and in shape.

But what should you buy for your liver? There are many choices available out there, and one of the more popular options among these is 1MD LiverMD.

So, continue reading as we dive into this LiverMD review to gauge its overall quality, effectiveness, value, and more.


About LiverMD

LiverMD is a liver supplement made by 1MD Nutrition, a supplement company that is dedicated to “helping people live longer, healthier lives through the powerful integration of advanced science and nature.” 1MD Nutrition is well-known in the health and wellness industry, having produced a large variety of popular supplements, including Complete Probiotics Platinum, CurcuminMD, and ImmunityMD, among many others.

As a liver supplement, LiverMD is made to support our liver health, with the notion that a strong liver equals a strong body. It is featured by 2 clinically proven and patented ingredients (Siliphos and EVNolMax) to support and maintain liver function. Plus, it includes numerous assisting ingredients to stimulate liver health and various liver functions. 

LiverMD Benefits

Specifically, LiverMD is advertised to:

  • Supports healthy liver function
  • Promotes liver detoxification
  • Support healthy metabolism and weight loss
  • Increase energy and focus
  • Increase antioxidant effects

Liver Function and Detoxification

LiverMD contains Siliphos and EVNolMax along with various essential nutrients and other ingredients designed for liver support, function, and detoxification. And since the liver is so important, it can contribute to whole-body health. 

Metabolism and Weight Loss Support

The makers also claim that LiverMD will aid in metabolism and weight loss due to the role that the liver plays in these areas. 

Increased Energy and Focus

By ridding the body of harmful toxins, LiverMD is designed to decrease sluggish feelings and increase energy levels and focus, along with overall brain health. 

Antioxidant Effects

Finally, LiverMD contains many different antioxidants designed to assist the liver and its enzyme levels, and even improve focus and clarity. 


Overall, these seem to be some impressive benefits. 

But let’s take a look at LiverMD’s ingredients to see what we are really getting inside and to figure out if LiverMD is really promising or not for liver health. 

LiverMD Ingredients

LiverMD contains 6 main ingredients. Namely, they are:

  • Siliphos
  • EVNolMax
  • Alpha Lipoic Acid (ALA)
  • L-Cysteine
  • Zinc
  • Selenium
  • Vitamin E

Let’s figure out the properties of each ingredient and how they might work!. Siliphos and EVNolMax are their two featured ingredients, so we’ll start with them.

LiverMD Supplement Facts


Siliphos is a patented form of milk thistle extract. Milk thistle is a plant that’s known to support liver and gallbladder health. Specifically, its active ingredient, silybin, helps in stopping toxic substances from attaching to the liver and keeps them from causing damage to our healthy cells. It is also said that silybin can aid in varying liver diseases such as hepatitis and liver cirrhosis, likely due to its role in the detoxification process.

Silybin also contains antioxidant and anti-inflammatory properties, making it great for protecting your body against inflammation and oxidative stress as well as liver damage.

Finally, Siliphos milk thistle extract has been clinically proven to have enhanced bioavailability and absorption compared to common or generic milk thistle extract. Overall, it is effective against liver disease and improves liver health. 

Most studies use around 420mg per day, but Siliphos is more bioavailable so the necessary dosage is likely less. 


Next up is EVNolMax, which 1MD labeled as their “supercharged” form of vitamin E. It contains both tocotrienols and tocopherols, which makes it a “full-spectrum” vitamin E supplement.

Vitamin E has potent antioxidant properties and vitamin E can protect our body from the damages caused by chronic inflammation and oxidative stress. This is very important because if chronic inflammation is left untreated, it can cause initially subtle but eventually major damage to the body. 

Fortunately, research shows that vitamin E (including the clinically tested EVNolMax) can naturally protect our liver from chronic inflammation and oxidative stress. Plus, it helps to stimulate new liver cells by encouraging proper cell division. all of this should help prevent liver disease (esp. nonalcoholic fatty liver disease), liver cancer, and other liver problems down the road.

100 to 200mg is typically used, though there is a bit of varianace.

Alpha Lipoic Acid (ALA)

Now let’s take a look at alpha-Lipoic Acid (ALA). ALA is another ingredient with a high antioxidant capacity, so it can be very helpful in defending your body against chronic inflammation and oxidative stress.

Furthermore, ALA plays a role in fat digestion and can help mitigate liver damage that occurs with excessive fat and triglyceride levels. And this is why some research shows it can be effective against fatty liver diseases. 

Plus, its effects on fatty acids (as well as insulin) make it beneficial for modest weight loss, as some studies show.

Usually, at least 300mg is most beneficial.


Next up is l-cysteine, which is created from N-acetyl cysteine. Generally, cysteine aids in the production of glutathione, which is the most potent antioxidant and detoxifier produced by the body. Research shows cysteine aids in detoxification and is particularly good at scavenging free radicals (which are harmful substances). 

Additionally, some research shows that cysteine can reduce LDL cholesterol levels and is able to decrease the build-up of fat in the liver. This is why it’s particularly effective against fatty liver disease.

In terms of dosage, 600 to 1,800 mg is generally effective.


Zinc is an essential trace mineral for overall health. Among its other health benefits, it has a vital role in supporting our immune system as well as hormonal health.

Aside from our immune system and hormonal health, zinc supports our liver health by reducing inflammation and oxidative stress. In fact, zinc is necessary for many liver functions and liver health, in which a zinc deficiency is strongly related to various liver diseases.

It also reduces apoptotic hepatocyte death, which is a condition where our liver cells start to self-destruct due to damage or lack of health. And this can eventually lead to liver failure.

Overall, zinc supplementation can protect against acute and chronic liver disease progression. 


Selenium is another trace mineral that also plays an essential role in our body. This mineral increases the function of antioxidants in our body, making them more effective in protecting us against oxidative stress. Selenium also plays a role in supporting thyroid function and other hormonal functions.

Selenium is also helpful in promoting detoxification for our body, and it is beneficial both for our liver and kidney health. Research shows selenium is protective against cirrhosis, hepatitis, and liver cancer. 


Does LiverMD Work?

Based on the ingredients and dosages, it is possible that LiverMD will benefit liver health and function.

The ingredients are of very high quality and well-researched, especially the two patented ingredients. However, a few of the ingredients have suboptimal dosages, such as Siliphos, ALA, and EVNolMax. So, as you can see, the main two ingredients are dosed too low, which limits its effectiveness. 

Nonetheless, since the other ingredients are dosed at the right amounts, coupled with the fact that every ingredient does have research behind it, LiverMD should offer improvements for liver health and overall health, especially in detoxification and reducing inflammation.

Claims vs. Reality

Remember that LiverMD is advertised to aid in detoxification and liver health, offer antioxidant properties, support weight loss and metabolism, and increase energy, focus, and brain health. 

In reality, only a few of these can definitively be judged. 

First, you definitely should experience a healthier and stronger liver, and you’ll likely get a boost in detoxification thanks to Siliphos, EVNolMax, as well as zinc, ALA, and other key antioxidants. 

Also, the inclusion of ALA may aid weight loss, but I wouldn’t expect anything noticeable in terms of a metabolic boost or weight loss.

Next, the antioxidant and anti-inflammatory benefits should occur since every ingredient in here acts as an antioxidant, whether it’s a primary or secondary feature. 

Lastly, LiverMD could theoretically improve energy, focus, brain health, and other aspects of health, given the connection between the liver and the rest of the body. But this can’t be stated definitively based on the research.

Overall, what you’re looking at with LiverMD is a product that can moderately boost liver health, detoxification, and antioxidant actions and the resulting benefits that come from those effects.

Who is it Best For?

LiverMD is best for people with current liver issues or individuals who want to prevent future liver problems down the road. If you are dealing with a current liver problem, common symptoms include jaundice, dark urine color, itchy skin, fatigue, and other issues. Always consult your doctor with any health concerns. 


LiverMD Safety and Side Effects

So far, there is no known major report that LiverMD causes side effects. However, it does not necessarily mean that the supplement will not cause any side effects anymore.

For starters, you should take the supplement in its proper dosage. Taking dosages more than what is recommended to you can cause mild or serious side effects.

Also, if you are pregnant or you’re currently taking any medications, you should consult your doctor first before taking any supplement to avoid any side effects that may harm your pregnancy or cause harmful interactions with your medications.

There are no listed side effects by 1MD Nutrition, but potential side effects include:

  • Abdominal pain, bloating, diarrhea, gas, indigestion, and similar symptoms
  • Loss of appetite
  • Lightheadedness, weakness, and tiredness

Also, LiverMD is free from preservatives and certain allergens, namely dairy, wheat, peanuts, and shellfish. 

Liver MD is also Good Manufacturing Practices (GMP) certified.

Where To Buy LiverMD

If you want to try out LiverMD, you can buy it here. You have many different options as you can choose to buy 1,3, or 6 bottles at a time, either as one-time purchases or through their Subscribe and Save program. And each bottle of LiverMD has 30 servings (60 capsules). 

Here are the prices, with the normal price on the left and the subscription price on the right:

1 bottle: $49.99 each; $40.99 each

3 bottles: $43.99 each ; $35.99 each

6 bottles: $37.99 each; $29.99 each

Clearly, the more you buy, the more you save. So the bulk options are definitely worth it if you find that the LiverMD supplement works well for you.

LiverMD Website

Additionally, if you sign up for automatic delivery, then the price for one goes to $45, and the price for 6 drops to $30 each, saving you over one hundred dollars.

LiverMDGet up to 40% off LiverMDWe scour the web for the best deals on supplements. Want up to 40% off LiverMD? Click the button below to get this deal!GET THE DEAL

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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.