AMPK Metabolic Activator Review – Does This Life Extension Supplement Work?

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By Scot Mills

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

AMPK Metabolic Activator Review

We all have fat for a reason, which isn’t to carry around as a status symbol. Instead, it’s your body’s emergency fuel supply to be used during times when your hunting-and-gathering efforts come up short. 

Oh wait, we have supermarkets now and no longer have to hunt, gather, or grow our food, which is probably why many of us have fat stores to survive the entire winter rather than just a few lean days. This is also compounded by many of our modern foods being highly processed, high glycemic, and packing in the empty calories. 

But there’s hope since, along with eating right, exercising, and getting adequate sleep, you can also successfully metabolize more fat using certain supplements. 

Here’s a look at one such supplement by Life Extension called AMPK Metabolic Activator. Life Extension claims this supplement will increase your cellular metabolism and decrease the love handles. Let’s find out if it can really help in this review of AMPK Metabolic Activator. 

AMPK Metabolic Activator

About AMPK Metabolic Activator

AMPK Metabolic Activator is a supplement made and sold by Life Extension, a Florida-based health supplement company. Life Extension produces a wide variety of supplements including Life Extension Migra-Eeze, Life Extension Bifido GI Balance, and Life Extension Senolytic Activator, among others.

AMPK Metabolic Activator combines calcium and 2-plant compounds in a simple formula they claim will activate your body’s fat burning by promoting AMPK enzyme activity. This is important to healthy weight management since the AMPK enzyme tells your body to stop storing fat and promotes the formation of ATP, which is used for cellular energy. 

This not only helps you burn body fat, but also boosts your energy and helps you maintain healthy cholesterol levels and vascular function.

AMPK Metabolic Activator Benefits

Promotes The Burning Of Belly Fat

While the AMPK enzyme is found in every cell of your body, its levels decline as you age. This is why it becomes so hard to lose belly fat as we age, since that’s also where fat tends to accumulate the most. 

But by restoring levels of cellular AMPK to where they once were, you can also restore your middle to the size it once was. Granted, you’ll also need to take measures beyond merely popping some pills, though Life Extension’s formula is a beneficial addition to your healthy eating and exercise program when it comes to lighting up fat stores. 

AMPK Metabolic Activator Benefits

Restores AMPK To Youthful Levels

As we age, our bodies produce less AMPK, which is an enzyme that’s highly beneficial in burning belly fat. Since there is a connection between low cellular AMPK levels and increased accumulation of abdominal fat, it would only make sense that restoring its levels will help you restore your flat belly. 

By promoting AMPK activity, your body is able to produce more ATP, which provides it with cellular energy. This increased energy also means an increased need for fuel, which is where your stored body fat comes in—no need to chase mammoths across the tundra just to burn it anymore!

Simple Formula That Contains 2-Potent Botanical Ingredients

When it comes to supplements, less is often better—especially when a few ingredients are all it takes to achieve the results you’re looking for. It also makes a difference that the ingredients are natural and safe, since what good is reducing your belly fat if the “cure” creates worse problems than what you originally used it for? 

By combining 2-potent botanical ingredients—Hesperidin and Actiponin gynostemma—that are both known to boost AMPK & ATP levels along with calcium and its ability to promote cellular fat burn, you can enjoy less belly fat, more energy, and better health. 

Boosts Cellular Metabolism

Fat is the fuel your cells need to function their best, though their ability to metabolize it diminishes as you age. By restoring AMPK enzymes to their youthful levels, you can also restore your cell’s ability to toss that spare tire on the fire to use as energy rather than love handles. 

AMPK Metabolic Activator Ingredients

Life Extension AMPK Metabolic Activator contains only 3 ingredients within its formula. These ingredients are calcium carbonate, hesperidin, and actiponin gynostemma extract. We will take a closer look at each of these ingredients below.

AMPK Metabolic Activator Supplement Facts

Calcium Carbonate 130 mg

Though we associate this essential mineral with bone health, calcium is also beneficial in burning fat at the cellular level. 

In fact, studies show that the higher the cellular calcium level, the more fat is burned. This can be as much as 42% higher in mice that were studied, though more importantly, in another study, those who consumed dairy over a 24-week period lost more weight (5lbs) and belly circumference (1.5”) than those who did not. 

Hesperidin [from orange extract] 500 mg

Derived from citrus fruits, hesperidin has antioxidant, anti-inflammatory, and anticarcinogenic properties as well as helping mediate AMPK and PPAR signaling pathways to help you burn more fat. 

This is an important “double-pronged” approach to lighting up fat stores, since oxidative stress leads to inflammation, which leads to obesity, and so do low AMPK levels in your cells. This is also a key to lowering your risk for many chronic diseases such as cancer and type II diabetes, both of which LOVE inflammation and excess body fat. 

Actiponin Gynostemma Extract 450 mg

Also known as Southern Ginseng, gymostemma is an herb known as an “adaptogen” for its ability to adapt to your body’s energy needs. It does this at a cellular level, and along the way, it also reduces your risk for chronic disease, lowers inflammation, and relieves symptoms of anxiety and stress. 

By increasing AMP-activated protein kinase (that’s the long way of saying AMPK) at a cellular level, it also helps rid you of belly fat while giving you the extra energy to hit the gym for yet more fat burn. 

Does AMPK Metabolic Activator Work?

As we’ve stated countless times when reviewing fat-burn supplements, there is no such thing as a magic weight loss pill. Instead, Life Extension’s product will work for you so long as you work for it. By this, we mean adding a commitment to a healthy eating and exercise program along with getting enough sleep, drinking enough water, and everything else necessary in staying lean, healthy, and energetic. 

On the other hand, if you want pills, you can chase with a bottle of Coke and a few beers before enjoying an afternoon of Twinkies on the couch, good luck, since such a thing only exists in the realm of The Fountain of Youth and time travel. 

AMPK Metabolic Activator For Weight Loss

Who Is AMPK Metabolic Activator Best For?

Anyone with belly fat to burn and a desire to burn it can benefit from this product. This includes gym rats and exercise enthusiasts, along with anyone getting older and experiencing the effects of age-related AMPK decline. 

AMPK Metabolic Activator For Losing Weight

But if you’re pregnant or nursing, you need to check with your doctor before using this product, and it is to be kept out of reach of children. You also need to stay within the recommended dose, and since this is screamed in all-caps on Life Extension’s website, we assume it to be critically important. 

Claims vs. Reality

So long as you do your part with healthy eating and exercise plan and stay within the recommended dose, AMPK Metabolic Activator will boost your cellular level of ATP so that you burn more fat. No, it’s not a magic pill, nor do they promote it as such, though it will take over where diet and exercise leave off and improve your overall results. 

Is AMPK Metabolic Activator Safe?

Life Extension’s product is neither a stimulant nor appetite suppressor but instead promotes healthy fat metabolism at a cellular level. By working naturally with your body to get your cells working at their optimum fat-burn capacity, there are few concerns with safety or side effects so long as you stay within the recommended dose.

But this doesn’t mean that some won’t be allergic or sensitive to any of its ingredients, though the product is backed by a generous 100% money-back, 12-month guarantee just in case you are.  

Where To Buy AMPK Metabolic Activator

AMPK Metabolic Activator starts at a reasonable $28.50 for about a 1-month supply, and you can save further through volume discounts or auto ship to bring your cost down as low as $24. Free shipping is also included with auto ship and orders over $50. 

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Along with Life Extension’s website, the product can be found at Walmart, Amazon, ProHealth, and many other independent and corporate stores, both online and brick-and-mortar.

Life Extension AMPK Metabolic Activator Website

Overall Rating:
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Scot Mills

Scot Mills is a nutrition writer who uses his unique skills and passions for natural products to share his research with others. Along with over twenty-years of experience working in natural industry sales, Scot graduated at the top of his class as a business major, and is a member of the Sigma Beta Delta honors society for his outstanding scholastic achievements. Scot specializes in using the latest scientific research to review supplements objectively. When he isn’t writing or hitting the gym, Scot can be found enjoying nature on epic trail runs, hikes, and mountain bike rides.

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