Dioxyme MPO Review – Does This Muscle Supplement Work?

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

dioxyme mpo review

As an athlete, you don’t just want to be one-dimensional. You want the whole package of speed, strength, muscle mass, endurance, power, and athleticism. Of course, getting to this point requires a lot of dedication and discipline, and sometimes the use of sports performance supplements is needed to maximize results.

So, let’s take a closer look at one specific option called Dioxyme Muscle Performance Optimizer (MPO). In this Dioxyme MPO review, we’ll discuss everything you need to know about this supplement to find out if it can help you get an edge on the competition when it comes to performance.

Ready to learn more? Let’s get started with this Dioxyme MPO review!

dioxyme mpo supplement

About Dioxyme MPO

Dioxyme MPO is designed to optimize all areas of athletic performance by causing significant changes at the biochemical level. It contains a unique blend of ingredients designed to give your muscles and nervous system the strength and energy they need to perform at an optimal level. Additionally, with its multi-faceted actions, Dioxyme MPO is designed for athletes of all types, from powerlifters, to football players, to endurance runners. 

Dioxyme MPO Benefits

The main benefits of Dioxyme MPO are increased strength and power, greater endurance and reduced fatigue, more muscle growth, better repair, and enhanced recovery. 

dioxyme mpo promotes strength and power

Strength and Power

Dioxyme MPO is designed to increase energy to the muscles and provide increased nervous system output, which is supposed to lead to increased strength and power. 

Endurance and Fatigue

By increasing energy to the muscle and central nervous system (CNS), Dioxyme MPO is also advertised to increase endurance and reduce both muscular and nervous system fatigue. In turn, this means longer and better workouts/competitions. 

More Muscle Growth and Repair

They also say that Dioxyme MPO increases a number of mechanisms in muscle protein synthesis, such as mTOR activation and growth hormone production. As a result, it is designed to promote high levels of muscle growth and repair. 

Enhanced Recovery

Finally, Dioxyme MPO is supposed to enhance both muscular and CNS recovery, leading to improved performance within each workout as well as better recovery between workouts. 

These are all benefits that any athlete or competitor wants. But will Dioxyme MPO actually give you these results? Read on to find out. 

Dioxyme MPO Ingredients

The ingredients in Dioxyme MPO are a combination of some well-known ones as well as a few very unique and lesser-known ones. Below is what’s in each serving (1 scoop) of Dioxyme MPO:

  • Creatine Monohydrate (4,500mg)
  • HMB (3,000mg)
  • Beta-alanine (2,000mg)
  • HICA (1,500mg)
  • Mediator Phosphatidic Acid (750mg)
dioxyme mpo supplement facts

Creatine Monohydrate

Up first is the very well-known creatine monohydrate. Creatine is abundant in the body, especially in skeletal muscles where it is stored as creatine phosphate. Essentially, creatine acts as an energy supply for the muscles, which helps to promote greater strength and power. A lot of research shows that creatine supplementation is particularly beneficial for strength and power athletes and other people engaged in high-intensity exercise as it can improve strength, power, and muscle mass. The most common dose used is 5g, although individual needs vary. 


The next ingredient included is HMB, which is a metabolite from the branched-chain amino acid leucine. HMB has a key role in protein metabolism and muscle hypertrophy, and it also increases muscle protein synthesis and growth hormone/IGF-1 activation, all of which promote better recovery and performance, and prevent muscle breakdown. HMB has a wide range of benefits for athletes, with research showing that it can improve aerobic capacity, strength, and power, as well as reduce fatigue and may even decrease body fat. 


Third on the list is beta-alanine, which is a non-essential amino acid that nonetheless plays a critical role in exercise performance. When ingested, beta-alanine increases muscle carnosine content, which in turn leads to greater muscular strength and energy levels. Research shows that beta-alanine supplementation can improve many aspects of high-intensity exercise capacity, such as strength, power, and muscular endurance. The most effective dosage is 4 to 6 grams daily, although benefits are seen from lower amounts in some cases.


One of the unique ingredients in Dioxyme MPO is HICA (alpha-hydroxyisocaproic acid). Like HMB, HICA is also a metabolite of leucine, and it is particularly beneficial for preventing muscle protein breakdown. While more research is needed, some studies show that HICA can reduce delayed-onset muscle soreness (DOMS) and increase lean muscle mass during training. The typical dose used is 1.5g daily. 

Mediator Phosphatidic Acid

The final ingredient in Dioxyme MPO is Mediator, which is a trademarked form of phosphatidic acid. Mediator is postulated to work by increasing mTor activation, which has anabolic effects. However, the current research shows no definitive benefits from phosphatidic acid on muscle mass or performance outcomes. This isn’t to say that it won’t work, but it’s still unclear. 

Does Dioxyme MPO Work?

All in all, Dioxyme MPO looks like it offers a number of benefits for overall athletic performance. It contains key ingredients that provide the muscles with strength and energy, increase power, reduce fatigue, and promote muscle growth and recovery. Also, the dosages of the ingredients are in solid amounts, although the dosage for beta-alanine is below the recommended dose. 

dioxyme mpo supplement pack

Another thing to consider is the synergistic effects that the ingredients may have on each other. For example, since they all offer the same general benefits of increased muscular and CNS output, they may create an even larger performance boost when paired together. 

Claims vs. Reality

Overall, the claims about Dioxyme MPO can likely stand. Creatine, HMB, and beta-alanine are all known for increasing strength and power, so I’d expect a moderate increase in this area. It is also likely that you’ll experience greater endurance and reduced fatigue, although this is more likely for anaerobic exercise rather than aerobic since most of the ingredients in here are best for higher-intensity exercise. In other words, lifters, football players, explosive athletes, and that sort are more likely to experience benefits as opposed to endurance runners, swimmers, and similar athletes. 

There are also key ingredients in Dioxyme MPO that should enhance muscle growth and repair, such as HICA. In turn, you will probably experience a reduction in muscle soreness and greater muscle growth compared to what usually occurs. 

Lastly, you will probably experience increased recovery not only between workouts but also within the workouts themselves. Since a lot of the ingredients stimulate the muscles and CNS and provide them with energy, you’ll likely experience a moderate decrease in the time it takes to recover between sets and between workouts. 

Overall, the benefits gained from Dioxyme MPO are likely moderate. I wouldn’t expect any massive changes in performance, but sometimes that little extra edge is all you need. 

Who is Dioxyme MPO Best For?

While the makers claim Dioxye MPO can be used by athletes of all types, it is likely that higher-intensity athletes will benefit the most from this supplement, given the way the ingredients work. The most pronounced benefits of Dioxyme MPO are increases in strength, power, muscular endurance, and hypertrophy, all of which relate the strongest to powerlifters, weightlifters, sprinters, and those sorts of athletes. This isn’t to say that people who are more on the aerobic/endurance spectrum wouldn’t benefit from Dioxyme MPO, but rather that it is not an ideal supplement for these people. 

dioxyme mpo best for athletes

Is Dioxyme MPO Safe?

Dioxyme MPO should be generally well-tolerated, but below are some possible side effects:

  • Bloating, nausea, and other stomach problems
  • Skin tingling

Also, Dioxyme MPO is produced in certified Good Manufacturing Practice (cGMP) facility to ensure quality and safety. 

Where to Buy Dioxyme MPO

You can buy Dioxyme MPO on the Dioxyme website at this link.

dioxyme mpo website

Dioxyme MPO contains 30 servings per container and costs $79.99 ($2.67/serving), so it is a pretty expensive product.

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They do offer a subscribe & save option, as well. If you choose to subscribe to Dioxyme MPO, you’ll get deliveries every month and you’ll save 10%, bringing the price down to $71.99.

Dioxyme MPO is designed to be taken on a daily basis, regardless if you have a workout/practice/game, in order to maximize the benefits. 

Overall Rating:
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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.