Best Polyphenol Supplements

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By Thomas Youngerman

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Best Polyphenol Supplement

Everyone wants to age gracefully. A solid diet and a good fitness routine can definitely benefit you when it comes to the aging process, but what if you want or need more?

Polyphenol supplements are here to help! These supplements can not only provide anti-aging benefits, but they can also reduce inflammation, benefit weight management, increase energy, and more. The only issue? Like most supplements, polyphenol supplements are not all made the same. Some can provide wonderful benefits, while others fall flat.

So, in this guide, we’ll solve the problem of which polyphenol supplement to use by giving you our picks for the best polyphenol supplements. Let’s get started!

Best Polyphenol Supplements

Here are our top picks. Keep reading to learn how we chose them.

  • Best Overall: Vitals Reds
  • Best for Energy: Energy Renew
  • Best Polyphenol Capsules: Polyphenomenal
  • Best Single-Ingredient Product: Resveratrol

Benefits of Polyphenol Supplements

Polyphenols have been indicated as providing a variety of health benefits including:

  • Reduced Inflammation 
  • Antioxidant
  • Enhanced Metabolism
  • Increased Energy
  • Promotes Tissue Repair
  • Weight Management
  • Healthier Skin
  • Gut Health 
  • Blood Sugar Support
  • Eye, Brain, and Heart Health
  • Anti-Aging

Additionally, polyphenols are linked to:

  • Lower blood sugar levels – reducing the risk of type 2 diabetes
  • Reduced risk of heart disease – due to antioxidants and reduced chronic inflammation
  • Protection against cancer – again due to the antioxidant and anti-inflammatory properties
  • Promotes healthy digestion – polyphenols may help probiotics thrive and survive
  • Improved cognition – polyphenol-rich foods may boost your focus and memory; cocoa flavonols may improve blood flow to the brain

How to Choose the Right Supplement

When picking the best polyphenol supplements, we adhered to strict criteria.

We ensured the products are manufactured in the U.S. in a certified cGMP facility (Good Manufacturing Practices). We also looked for companies and brands that have independent third-party testing such as NSF, Informed Choice, or Safe for Sport certifications.

Additionally, having a Money-Back Guarantee was important to us as it indicates the manufacturer’s confidence in its product. Finally, whenever possible, we opted for natural, organic ingredients

What to Look For

  • High-quality ingredients
  • Professionally-formulated blends
  • The RIGHT polyphenols
  • A healthy blend of superfood compounds and other ingredients
  • Trustworthy manufacturers
  • Third-party quality testing

What to Avoid

  • Low-quality ingredients
  • Ineffective blends
  • Too much marketing “hype”
  • Fillers
  • Sketchy manufacturers
  • Lack of quality oversight

Top Rated Polyphenol Supplements

At Fitness Clone, we have reviewed over 500 supplements. We pay close attention to supplement formulations, ingredient quality, manufacturing practices, and company trustworthiness. Here are our 4 top-rated polyphenol supplements.

Best Overall

Vital Reds

by Gundry MD

Gundry MD’s dedication to providing high-quality, top-of-the-line supplements has landed two of its products on our list.

Vital Reds is a superfood supplement powder from Gundry MD. This supplement contains a concentrated polyphenol blend with over 50 different ingredients. These ingredients include polyphenols, metabolism-boosting ingredients, ingredients for digestive support, probiotics, vitamins, and minerals.

Vital Reds is designed to boost energy and reduce fatigue. Additionally, it also provides benefits including improving and repairing skin, promoting fat burning, and assisting in healthy digestion.

Vital Reds


  • Formula includes a reds blend, a blend for enhancing metabolism, and a blend for supporting digestion
  • Designed to promote energy, improve digestion, and repair skin
  • Comes in a delicious red-berry flavor
  • Provides additional amino acids and vitamins
  • Backed by Dr. Steven Gundry
  • Clean and natural formula that is soy-free, sugar-free, and artificial sweetener-free
  • Manufactured in the USA
  • 90-day money-back guarantee


  • Can be expensive without any discounts

Or Read the Review

Best for Energy

Energy Renew

by Gundry MD

Energy Renew is another supplement from Gundry MD, founded by Dr. Steven Gundry. Dr. Gundry was a world-renowned cardiologist before founding his Center for Restorative Medicine in Loma Linda, CA. He has spent the past twenty years studying the human microbiome, and today is one of the industry’s pre-eminent experts on polyphenols and digestive health.

Energy Renew is a powdered dietary supplement formulated with vitamin C, D Ribose, N Acetyl L-Carnitine, and an antioxidant-rich Polyphenol blend designed to support muscle recovery and cardiovascular health.

Energy Renew has one flavor available, Passion Fruit. Each jar delivers thirty servings of seven-gram scoops. Gundry recommends you mix one scoop with ten ounces of water daily for best results.

Energy Renew


  • Formula includes an antioxidant-rich Polyphenol blend
  • Promotes all-day wakefulness and clearer thinking
  • Designed to support muscle recovery and cardiovascular health
  • Backed by Dr. Steven Gundry
  • 100% Natural, contains no artificial sugars
  • Manufactured in the USA
  • 90-day money-back guarantee


  • Can be on the pricey end without discounts

Or Read the Review

Best Polyphenol Capsules


by Bulletproof

Polyphenomenal is a polyphenol supplement from Bulletproof, a well-known health supplement company with a variety of highly-rated products.

Polyphenomenal delivers antioxidants from a broad-spectrum polyphenol-rich blend of berries and botanicals, including pomegranate, turmeric, and green tea to help fight free radicals and support healthy aging. 

In addition to healthy aging and fighting free radicals, Polyphenomenol also provides benefits including combatting oxidative stress and supporting healthy immune function.



  • Contains a unique blend of 9 polyphenol-rich botanicals and berries
  • Is vegetarian/vegan-friendly
  • Designed to support healthy aging and combat oxidative stress
  • Provides all-in-one daily antioxidant support
  • Comes in easy-to-use pill capsule form
  • All-natural with plant-based antioxidants


  • Does not include a probiotic blend like other options

Best Single-Ingredient Product


by Purely Beneficial

Resveratrol is a resveratrol and polyphenol blend supplement from Purely Beneficial. This supplement is designed to support heart health, anti-aging, and blood pressure.

Resveratrol’s formula includes vitamin C as well as a Trans Resveratrol Complex and a Polyphenol Complex. Included in these complexes are the ingredients Japanese knotweed extract, green tea extract, grape seed extract, acai extract, red wine extract, pomegranate extract, blueberry extract, noni fruit extract, alfalfa leaf extract, and hawthorn berry extract. 

Resveratrol contains no fillers, artificial ingredients, or harmful preservatives. Additionally, all Purely Beneficial products are made in the USA in an FDA inspected cGMP facility, and the company backs the product with a 100% money back guarantee.



  • Contains 100% natural ingredients
  • Vegan-friendly
  • Benefits heart health, anti-aging, and blood pressure
  • Includes 1450mg of a highly potent Resveratrol Blend
  • Convenient and easy to swallow pill capsules
  • NO fillers, preservatives, gluten, or artificial ingredients
  • 100% satisfaction guarantee


  • Does not include a probiotic blend like other options

Common Questions About Polyphenol Supplements

What exactly are polyphenols?

Polyphenols are nutrients naturally found in plant foods, responsible for their health-promoting properties. Examples include berries, vegetables, spices, coffee and tea, herbs, and dark chocolate. The more colorful the plant – the higher the polyphenol content. Polyphenols protect plants against the sun’s radiation and help defend them against disease.

Foods rich in polyphenols and polyphenol compounds protect us similarly, acting as antioxidants and helping combat inflammation, among other essential benefits.

What are the different forms of polyphenols?

These supplements come in a myriad of forms from powdered mixes, to tablets and capsules, and gummies. How and when you use the products will vary by brand and method of delivery.

What are the different types of polyphenols?

There are quite a few different types of polyphenols, below are a few of the most common.
The first type is flavonoids. Flavonoids are the largest group of phytonutrients, with more than 6,000 types, found in almost all fruits and vegetables. Flavonoids and carotenoids are responsible for the vivid colors in fruits and vegetables. In supplementation, quercetin from green vegetables, apples, or onions is the most popular compound.

The next type of polyphenols is phenolic acids. Phenolic acids are a phytochemical found in the seeds, skins of fruits, and leaves of vegetables. Green tea and caffeine are two of the more recognizable compounds in this group.

One final common type of polyphenol is polyphenolic amides. This category includes the capsaicinoids found in chili peppers and the powerful antioxidant avenanthramides found only in oats. The compound capsaicin is frequently used in weight loss supplements and is thought to have benefits in increasing metabolism by burning fats.

Many of the remaining polyphenols are popular in supplementation, including resveratrol from red wine, curcumin, and turmeric, and the lignans in flax seeds, sesame seeds, and whole grains.

What are the best polyphenols for addressing free radical damage?

It’s all about antioxidant polyphenols. In 1956 Denham Harman, a Cal Berkley Ph.D. theorized that free radicals were a primary contributor to aging and death, the “free radical theory of aging.” Generations of scientists have followed in Harman’s path, exploring the role of free radicals in aging and disease and the effectiveness of antioxidants to forestall both. We have since learned that free radical damage is a chief contributor to the most common diseases of aging, including cancer, heart disease, diabetes, Alzheimer’s disease, and even arthritis.

Some of the most potent antioxidant polyphenols used in the natural products space include green tea extract, CoQ 10, resveratrol, quercetin, cocoa beans, pomegranate, and caffeine.

What are the best polyphenols for potent anti-inflammatory properties?

There are two types of inflammation, acute inflammation, and chronic inflammation. Acute inflammation happens when you experience swelling, as with inflamed joints, arthritis, or infection. Chronic inflammation is more severe and more deadly.

The insidious thing about chronic, low-level inflammation is that it so often has no symptoms or signs; plaque in arteries, bacteria, or cells dividing uncontrollably as in cancer. Some experts believe that if we could eliminate chronic inflammation, we could slash the chance of heart disease and cancer by 50%.

Research on the dangers of systemic inflammation indicates it is a much more significant factor in the diseases of aging than most people, or even their doctors realize. It now appears to be a primary risk factor for cancer, Alzheimer’s disease, and heart disease. Understanding and controlling systemic inflammation is critical to disease prevention and life extension.

Some of the polyphenol compounds with the most potent anti-inflammatory properties include quercetin, rutin, morin, hesperetin, and hesperidin.

How do polyphenols affect aging?

What causes us to age? We often think of aging as the things we lose or that decline or decay over time, such as wrinkles, graying hair, less muscle mass, less energy, and decreased libido. So, is aging inevitable?
Scientists theorize that aging is accumulated wear and tear from toxins, free-radical damage, chronic inflammation, declining hormone levels, DNA-damaging radiation, disease, and stress. The thinking is that eventually, our bodies wear out and can’t fight back.

Contrast this with a theory offered by Dan Buettner in Blue Zones:

“Scientific studies suggest that genes dictate only about 25 percent of how long we live. The other 75 percent is determined by our lifestyles and the everyday choices we make. If we optimize our lifestyles, we can maximize our life expectancies within our biological limits.”

At what age should one start an anti-aging regimen? Skincare companies will tell you that skin begins to age in your twenties and that an ounce of prevention is worth a pound of cure. Dan Buettner suggests that optimizing lifestyle choices, particularly diet and exercise, should start as early as possible.

In addition to these lifestyle changes, though, supplements can help push your health to the next level and fill in the gaps for areas currently missing. That’s where polyphenol supplements swoop in to save the say. These nutrients, naturally found in plant foods, can provide a wide variety of health benefits including reduced inflammation, increased energy, antioxidant effects, and more. In this guide, we will take a more thorough look at polyphenol supplements and their key ingredients, and give you our picks for the best polyphenol supplements worth adding to your diet routine.

Can you get polyphenols through your diet alone?

Although most people don’t take in sufficient polyphenols through diet alone, there are foods you can choose to improve your antioxidant and anti-inflammatory properties. Some of the best-known sources are Dark Leafy, Vegetables, Cocoa, Berries, Green tea, and Coffee.

Although these are some of the best-known sources, many other foods offer significant amounts of these compounds, some delightful such as red wine and dark chocolate.

Other supplements high in antioxidants and anti-inflammatories would be Vitamin C, A, and E. beta-carotene, and Astaxanthin.

Will polyphenol supplements work for you?

Just a quick review of the attributes of polyphenol supplements leads us to a resounding, yes! Understanding the dangers of free radical damage and chronic inflammation alone is sufficient reason to endorse these powerhouse polyphenols. Add to that the fact that diet alone does not achieve the recommended daily intake, plus the NCBI’s documented and published clinical trial evidence – we endorse the use of polyphenol supplements.

That said, we caution against the prudent use of these supplements as the higher quantity of polyphenols in some supplements may exceed recommended doses.

Are polyphenol supplements safe?

No doubt, polyphenol-rich foods are safe for most people. Some polyphenol supplements can interact with medications or nutrient absorption. They may reduce your body’s ability to absorb other essential elements.

When considering adding a new supplement to your regimen, talk to your doctor first, particularly if you have a diagnosed nutrient deficiency or are on prescription medicines.

Are there any clinical studies of polyphenol supplementation?

Per the National Center for Biotechnology Information, clinical studies on fruit-derived polyphenols’ effect on athletic performance indicate they may enhance endurance and recovery from exercise-induced muscle damage.

“Fruit-derived polyphenols have antioxidant and anti-inflammatory properties and can enhance exercise performance, since excess reactive oxygen species generation has been implicated in fatigue development, and enhance recovery from intensive exercise due to the involvement of inflammation and oxidative damage within muscle.”

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Thomas Youngerman

Thomas Youngerman is an entrepreneur and author in the health and wellness space with extensive experience in the supplement industry. He has owned multiple sports nutrition stores and served as the Category Manager and Director of Business Development for a regional chain of nutrition stores. Thomas created a successful line of men’s healthy aging supplements that was distributed in GNC, The Vitamin Shoppe, and Kroger, and later sold to a West Coast corporation. Thomas was previously a certified nutrition coach. He has a strong understanding of nutrition, supplement formulations, DSHEA, cGMP, and FDA regulations.