What Is An AMPK Activator? – A Thorough Look At What This Supplement Can Do

We seem to mention lifestyle changes in conjunction with virtually every health regimen we discuss. Changes include cleaning up your diet and choosing to exercise more. We know the benefits of exercise – increasing muscle, burning calories, improving body composition, more lean muscle, and less fat. What if you could convince your body you were pumping iron or jogging, rather than reading a book or streaming a video? Forget “no pain, no gain,” in this article; we will introduce you to the world of AMPK Activator supplements, designed to stimulate AMPK, mimicking the effect of exercise in your muscles and cells.

So, what is an AMPK Activator? Let’s find out!

AMPK Activator

AMP-Activated Protein Kinase (AMPK) – The Energy Enzyme  

AMP-activated Protein Kinase (AMPK) is a fuel-sensing enzyme present in your body’s cells and plays a role in cellular homeostasis (balancing or establishing equilibrium within your cells). During exercise, AMPK is activated in your skeletal muscle, in adipose tissue, your liver, and other organs. When activated, such as when cellular energy is low, AMPK stimulates energy-generating processes such as glucose uptake and fatty acid oxidation and decreases energy-consuming processes such as protein and lipid synthesis. Exercise is the most potent physiological activator of AMPK, activated when intracellular ATP levels are lowered. ATP or Adenosine triphosphate is the organic compound that provides energy to drive processes in your cells – it’s the source of energy used to power the movement of contractions in working muscles. 

AMPK is often called the “master metabolic regulator” – it switches on the same fat-burning and energy-producing metabolic processes that exercise does.

AMPK Activator For Flat Tummy

What Is An AMPK Activator?

Like other hormones and bodily systems, AMPK levels decline with age, contributing to age-related weight gain, particularly in abdominal adipose tissue. So back to our original premise, what if you could convince your body that your ATP levels are lowered due to exertion or calorie restriction so that you could stimulate or activate AMPK to stop storing and start burning body fat? That is the role of a relatively new category of supplements, AMPK Activators.

This article will explore the other purported benefits of AMPK activation, such as lowering blood sugar levels, preventing metabolic disorders, reducing inflammation, and anti-aging. We will review several of the more popular AMPK activation ingredients, cite findings from clinical studies on AMPK activation, and provide several recommendations of the best products currently on the market. 

If shedding excess body fat is one of your goals, we think you will find this review intriguing. But, don’t be surprised if, in our efficacy comments, we recommend a few additional stressors such as Intermittent fasting, calorie restriction, and intense exercise, to provide even greater AMPK activation. 

AMPK Activator For Weight Loss

Types Of AMPK Activator Supplements

Nearly all AMPK Activator Supplements come in capsule form. They are either single-ingredient products (generally ActiveAMP, a generic form of Gynostemma pentaphyllum, or Berberine) or formulations containing a combination of the ingredients discussed below. The lone exception is Jiaogulan Herbal Tea, a form of Gynostemma tea. See more on Gynostemma below.

Key Ingredients In AMPK Activators

One of the most prevalent AMPK Activating ingredients is the herb Gynostemma pentaphyllum. Rather than using a generic form of this herb, we applaud the brands that opted for a patented, trademarked and clinically validated ingredient such as ActiveAMP® from Gencor.

Check Out Our 9 Top Rated Supplements
Our team has reviewed hundreds of popular supplements - these are our 9 favorites.
Click Here to check out the list.
AMPK Activator To Burn Fat

Active AMP From Gencor – Gynostemma Pentaphyllum

Gencor is a prominent ingredient supplier in the natural products space with several patented and trademarked ingredients, including ActiveAMP. Their clinically studied ActiveAMP is extracted from this adaptogenic herb (Gynostemma pentaphyllum), which contains compounds that regulate metabolic processes typically produced during exercise. 

A double-blind, placebo-controlled study (the gold standard in clinical studies) on eighty overweight participants showed statistically significant decreases in the active group compared to the placebo group in reducing body fat, weight, and BMI (Body Mass Index), and total abdominal fat area.

Other Popular AMPK Activator Ingredients

Berberine – other than Gynostemma pentaphyllum, is the only ingredient used as either a stand-alone product or the other ingredients in this list. Berberine, known to activate AMPK, is a super antioxidant that may improve several age-related issues, such as lowering your bad cholesterol, balancing blood sugar, digestion, heart health, and weight loss. 

Alpha Lipoic Acid – a fatty acid that plays a crucial role in metabolism and energy production. It functions as an antioxidant and has anti-inflammatory properties. 

Hesperidin – a “bioflavonoid” most commonly found in citrus fruits. Hesperidin may help regulate blood sugar, cholesterol, and provide energy for athletic performance.

Resveratrol – from red grapes’ skin and seeds is a potent antioxidant with anti-inflammatory and anti-microbial properties. It’s used in AMPK formulations for its ability to lower cholesterol and protect against obesity.

Calcium – is a mineral that plays an essential role in building bones and keeping them healthy. Calcium also enables our blood to clot, our muscles to contract, and our heart to beat.

Quercetin – a flavonoid that acts as an antioxidant and anti-inflammatory to reduce inflammation, control blood sugar, and help prevent heart disease.

Forskolin – a popular ingredient in many sports nutrition and weight loss supplements, forskolin helps the body burns fatty acids.

Curcumin – one of the most popular ingredients in the natural product space, is the main active ingredient in turmeric. It has powerful anti-inflammatory and antioxidant effects and is thought to be beneficial in combatting many serious health issues.

Carnitine – another popular ingredient in weight loss supplements. Carnitine transports long-chain fatty acids into mitochondria to be oxidized for energy production.

Clinical Studies Of AMPK Supplementation

Per the National Center for Biotechnology Information, recent clinical studies on AMPK Activation show promise for: 

“Considering the extensive effects of AMPK within the cell, it is no surprise that there are many and varied activators of AMPK. Many of these activators show promise for the treatment of a wide variety of health issues including diabetes, cancer, and cardiovascular disease.”

PubMed quotes a National Library of Medicine study:

“AMPK is a key player in regulating energy metabolism, placing it at the center stage in studies of diabetes and related metabolic diseases. AMPK is activated in response to a variety of stimuli, including cellular stress, exercise, and a wide range of hormones and agents that exert impacts on cellular metabolism. Genetic and pharmacological studies demonstrate that AMPK is required for maintaining glucose homeostasis. Activation of AMPK by pharmacological agents presents a unique challenge, given the complexity of the biology, but holds a considerable potential to reverse the metabolic abnormalities associated with type 2 diabetes.”

Given the potential of AMPK Activation, we anticipate continued growth and a plethora of new entries in the category.

AMPK Activator Benefits

Although clinical studies focus on the benefits of AMPK Activation in severe health issues such as cancer, heart disease, and diabetes, the natural products companies market the product differently due to FDA and FTC regulations. The benefits indicated by supplement manufacturers include:

  • Regulates Energy Usage 
  • Supports Weight Loss
  • Decreases Inflammation (actually, a health claim according to the FDA) 
  • Improves Metabolic Pathways and Insulin Sensitivity
  • Improves Physical Performance
  • Supports Healthy Aging
  • Encourages the Body to Burn Stored Abdominal Fat
  • Restores youthful AMPK levels

Will An AMPK Activator Supplement Work For Me?

Every person’s anatomy and response to supplementation is different. However, the preponderance of evidence indicates that added or activated AMPK has significant health benefits. Clinical studies prove that activators will switch on the same fat-burning and energy-producing metabolic processes that exercise does.

The ingredients used in Activators are all proven performers in the natural products space, particularly Berberine, Curcumin, Resveratrol, Quercetin, and Carnitine. Even taken alone, these supplements will have significant healthful benefits.

How to increase the odds that AMPK Activators will work for you? Stressors such as intermittent fasting, severe calorie restriction, and intense exercise are known to activate AMPK. So, a clean diet and exercise finally make their appearance in this article, as methods to augment your AMPK Activator for optimum results.

Are AMPK Activators Safe?

In clinical studies, some participants experienced stomach pain, cramping, flatulence, diarrhea, and constipation.

When considering adding any new supplement to your regimen, talk to your doctor first, particularly if you are on prescription medicines.

Best AMPK Activators

When making our selections for recommended NMN supplements, we adhered to the following criteria:

  • Our preference for a patented, clinically tested ingredient played a significant role in our choices.
  • We ensured the products are manufactured in the U.S. in a certified cGMP facility (Good Manufacturing Practices). 
  • We looked for companies and brands that have independent third-party testing for quality and purity.
  • Having a Money-Back Guarantee was important to us as it indicates the manufacturer’s confidence in its product.

Active-PK by LCR Health 

Active-PK by LCR Health 

Our first selection comes from LCR Health (Live Cell Research) of Woodland Hills, CA, an anti-aging supplement and nutraceutical company. Active-PK has only three ingredients, each indicating its precise dosage, and one is a clinically proven, patented ingredient, ActivAmp®, manufactured by Gencor Labs. The other ingredients are Berberine and Quercetin. We love the formulation and the company’s go-to-market strategies, including their cGMP certification, third-party testing, and quality guarantee.

On the company website, a thirty-day supply retails for $89.95. There are also special offers for sixty-and-ninety-day supplies. On Amazon, sixty capsules, a thirty-day supply sells for $52.95.

SAVE UP TO 60% ON ACTIVE-PK

AMPK Metabolic Activator, from Life Extension

AMPK Metabolic Activator, from Life Extension

Life Extension is one of the most respected brands in the healthy aging space. Their AMPK Metabolic Activator features Actiponin®, another patented Gynostemma extract, combined with Calcium and Hesperidin.  

Life Extension maintains a Certificate of Analysis on file for every product manufactured and offers a Money-Back Guarantee on all products.

Thirty-servings retail for $28.50 on the company website.

GET THE BEST PRICE ON AMPK METABOLIC ACTIVATOR

Jiogulan Tea from Immortalitea

Jiogulan Tea from Immortalitea

We wanted to round out our best of products with a representative product from the Jiogulan Tea variety. Jiogulan Tea is from Gynostemma pentaphyllum, the most potent form of AMPK Activator on the market today. Traditional Chinese Medicine and modern science agree, our bodies need the synergistic effects of full-spectrum herbs. Pharmaceuticals and extracts manufactured with chemistry are less effective. Immortalitea gynostemma organic tea is pure 100% gynostemma pentahyllum leaf, is naturally sweet and brews a bright green delicious caffeine-free herbal tonic.

An eight-ounce bag retails for $27.28 on Amazon.com. The product costs $9.95 for a fifteen-teabag package on the company website immortalitea.com. The company also offers a 100-count, 500 mg capsule package for $19.83. 

GET THE BEST PRICE ON IMMORTALITEA JIOGULAN TEA

Stacking AMPK Activator Supplements

Suppose you are taking a single ingredient product such as Berberine or Gynostemma pentaphyllum. In that case, even if you are using ActiveAMP, we believe there are benefits to stacking your product with the other ingredients listed in our review:

  • Alpha Lipoic Acid 
  • Hesperidin 
  • Resveratrol 
  • Calcium 
  • Quercetin 
  • Forskolin 
  • Curcumin C
  • Carnitine

To Summarize: AMPK Activators

We find AMPK Activators’ science intriguing and love the concept of tricking our bodies into thinking we have exercised to help achieve our weight loss goals. The clinical studies and quality ingredients in these formulations give us confidence in recommending you consider adding an Activator to your supplement arsenal.

You May Also Like
What Foods Does Dr. Gundry Recommend? – A Complete Guide

What Foods Does Dr. Gundry Recommend? – A Complete Guide

Dr. Steven Gundry is one of the natural products industry's leading experts on the microbiome and digestive and immune health. After a distinguished career as one of the world’s pre-eminent experts in heart surgery, Dr. Gundry founded the Center for Restorative...

Benefits Of Niacinamide – Can It Support Your Overall Health?

Benefits Of Niacinamide – Can It Support Your Overall Health?

With so many available and countless skincare ingredients on the market, it can be hard to choose what's right for your skin type. Trying to navigate what skincare ingredients are really effective in your skincare ingredients can also be quite the process. ...

Benefits Of DHEA – How Can It Help Your Health

Benefits Of DHEA – How Can It Help Your Health

Hormones are well-known for their astounding ability to make our lives better or worse. They’re markers in our bodies that can either provide us with energy, or leave us feeling sluggish and out of it. They have a variety of different functions, from regulating...

Benefits Of Castor Oil – What It Does For Your Health

Benefits Of Castor Oil – What It Does For Your Health

Have you heard of Castor Oil? It’s quite a popular oil these days that has a variety of benefits and purposes. Would you believe us if we told you the benefits range from hair growth to help induce labor?  In this article, we are going to discuss castor oil, what...

Benefits Of Multivitamins – Why You Should Take These Supplements

Benefits Of Multivitamins – Why You Should Take These Supplements

Multivitamins are a go-to supplement for many adults who are living in a fast-paced world of work. They are one of the most commonly known and used supplements in the world, and for good reason.  The popularity of multivitamins usage has increased rapidly in the...

Disclosure: Some of the links in our articles are from our advertisers. Learn more about how we make money.

Contents

Reviews

Latest Fitness Profiles

Keanu Reeves

Keanu Reeves

facebooktwitteryoutubeinstagramKeanu ReevesActor Born: 1964Keanu Reeves was born in Beirut, Lebanon. His father abandoned the family when he was just 2 and Reeves and his mother moved to Australia and New York City before settling in Toronto, Canada. His mother...

Zachary Levi

Zachary Levi

facebooktwitteryoutubeinstagramZachary LeviActor Born: 1980 Zachary Levi Pugh was born in Louisiana but his family moved around and lived in several states before settling in California. Levi began acting on stage in regional productions at age 6. His first tv...

Rob McElhenney

Rob McElhenney

facebooktwitteryoutubeinstagramRob McElhenneyActor Born: 1977Rob McElhenney is from Philadelphia, PA. His parents divorced when he was 8 and his mother came out as a lesbian. He attended Temple University but did not complete a degree. McElhenney’s found small roles...

Taylor Lautner

Taylor Lautner

facebooktwitteryoutubeinstagramTaylor LautnerActor Born: 1992Taylor Lautner is from Michigan. Always active, Lautner took his first karate class at age 6, earned his first black belt at age 8 and won several junior world championships. In middle school, Lautner...

Eva Longoria

Eva Longoria

facebooktwitteryoutubeinstagramEva LongoriaActress Born: 1975Eva Longoria Bastón is originally from Texas. While she was in college earning a degree in kinesiology at Texas A&M, she won the 1998 Miss Corpus Christi USA title. A talent contest after college led her...

Latest Reviews

Iconic Protein Drink Review – Is It Really A Healthy Choice?

Iconic Protein Drink is a protein drink made of grass-fed cow’s milk. This protein shake has a total of 20 grams of protein per bottle, and it also includes a complete amino acid profile. This shake also contains BCAAs (branched-chain amino acids) and has been...

Related Articles

Benefits Of Juicing – 9 Reasons To Drink Your Fruits And Veggies

Our world is becoming more health-conscious day by day and it's no surprise many people are taking their health seriously. With a lot of emerging infectious disease, and some diseases sprouting from poor lifestyle choices, people are searching for ways to improve...

Benefits Of Circuit Training – Why This Workout Works

With so many types and different styles of working out and exercising, one of the most well-known is circuit training. Circuit training is popular for good reason, it provides a variety of health benefits while helping consumers build muscles and maintain a low level...

Benefits Of Chaga – What Can These Mushrooms Do For Your Health?

When most people think of mushrooms, they think of those white buttons and portobello mushrooms commonly found in the grocery store. While we have nothing against those mushrooms, they simply don’t compare to the power of functional mushrooms.  Functional...

Benefits Of A StairMaster – What Can It Do For Your Health?

When it comes to choosing the best exercises and machine equipment to use at your gym, it can be overwhelming. From treadmills like the Treadly 2 to rowers such as the Hydrow Rower, it can be pretty difficult to choose what gym equipment is best in helping you...

Top Rated Supplements
Best Supplements

Our team has reviewed hundreds of popular supplements - these are our 9 favorites.


Check Out the List

Pin It on Pinterest

Share This