About Neo40
Neo40 is a nutritional supplement designed to boost nitric oxide production. By increasing nitric oxide levels, manufacturer HumanN claims Neo40 can enhance overall cardiovascular function. The combination product dissolves on the tongue rather than being swallowed. Neo40 should be taken for 30-45 days before results appear according to the supplement maker. It’s worth noting that HumanN is currently involved in a lawsuit with Thermo Fischer regarding patent disputes and false marketing claims.
Benefits of Neo40
Support Healthy Blood Pressure
Neo40’s primary mechanism involves boosting nitric oxide production. This crucial gas molecule relaxes smooth muscle surrounding blood vessels, leading to reduced blood pressure.
Support Cardiovascular and Heart Health
Healthy blood pressure directly contributes to improved heart and cardiovascular function. If Neo40 effectively lowers blood pressure through nitric oxide enhancement, overall cardiovascular health should benefit accordingly.
Support Healthy Arterial Function
Beyond relaxing blood vessel muscles, nitric oxide actively protects vessels from plaque formation. This enables arteries and veins to function optimally while maintaining their natural elasticity.
Ingredients
Vitamin C
Vitamin C functions as a potent antioxidant with established immune support properties. Research suggests it may improve blood pressure, though most studies examining this effect were relatively brief. The optimal dose appears to be approximately 500mg daily. Neo40 contains only 100mg, making it unlikely that its vitamin C content significantly impacts blood pressure.
Vitamin B12
Vitamin B12 serves as a critical coenzyme in breaking down homocysteine. While everyone naturally produces this chemical, excessive levels prove dangerous. Elevated homocysteine dramatically increases heart attack, stroke, and cardiovascular event risks. Vitamin B12 participates in the methylation cycle, helping reduce homocysteine levels. In patients with high homocysteine, normalizing levels can also improve blood pressure.
Proprietary Nitric Oxide Blend (428mg)
Beetroot Powder
Beetroots provide concentrated nitrites, which convert readily into nitric oxide—the gas molecule that opens blood vessels and relaxes smooth muscle. Research demonstrates that consuming nitrite-rich sources, like those from beets, elevates nitric oxide levels and improves blood pressure. Most research focuses on beetroot juice. Without knowing the nitrate concentration in this beetroot powder extract, determining its effectiveness for nitric oxide enhancement proves difficult.
Hawthorn Berry Extract
Hawthorn berry (crataegus azarolus) has demonstrated positive blood pressure effects, though conflicting information exists. Some hawthorn berry extracts may actually increase blood pressure. Several studies show hawthorn berry effectively addresses hypotension (low blood pressure) in teens and adults.
L-Citrulline
This amino acid plays a key role in nitric oxide production. If you’ve browsed supplement stores like GNC, you’ve likely noticed shelves stocked with arginine supplements. Arginine is required for nitric oxide synthesis, during which it converts to L-citrulline. Eventually, L-citrulline can convert back to arginine, restarting the cycle. Unlike arginine, L-citrulline absorption faces no restrictions. Our liver limits excessive arginine absorption, but L-citrulline bypasses this barrier. L-citrulline supplementation more effectively boosts nitric oxide than arginine. Neo40’s proprietary blend totals 428mg, while L-citrulline typically requires 3g dosing for blood pressure benefits.
Sodium Nitrite
This nitrate converts readily into nitric oxide, reducing blood pressure. Sodium nitrite is typically dosed around 100mg daily. Interestingly, Neo40 contains both beetroot and sodium nitrite, despite beetroot being a natural nitrite source.
Does Neo40 Work?
Neo40 contains several ingredients with proven blood pressure benefits. Vitamin C and B12 effectively reduce oxidative stress and homocysteine levels. The remaining ingredients target nitric oxide production. Combined, these components should produce meaningful effects. However, based on existing literature, the doses appear insufficient for significant impact. The product does have clinical trial support, though the study involved relatively few participants and lacks sufficient power for strong validity. More robust trials with larger participant groups would enhance Neo40’s credibility.
Claims vs. Reality
Neo40 contains numerous ingredients individually tested for blood pressure benefits. However, comparing Neo40’s ingredients to research findings reveals concerning underdosing across all components. Additionally, ingredient quality remains unassessable since none are standardized for specific active compound concentrations.
Despite these limitations, Neo40 has undergone clinical testing—something most supplements avoid entirely. While their claims may be overstated, evidence suggests Neo40 can provide meaningful benefits for individuals with elevated blood pressure.
Who is Neo40 best for?
The Neo40 study involved patients clinically diagnosed with hypertension. However, this product may better suit those at risk of developing high blood pressure. Consider this product a preventive measure to keep numbers from climbing to medication-requiring levels.
Safety
Anyone with cardiovascular disease history or currently taking cardiovascular medications should consult their physician. Neo40’s ingredients can enhance or inhibit certain medication effects, potentially requiring dosage adjustments.
Where to Buy Neo40
