Isotonix OPC-3 Review – Is This Supplement A Healthy Choice?

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By Alexa DaFonte

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

Isotonix OPC-3 Review

Isotonix OPC-3 is an isotonic-capable food supplement that consists of a blend of red wine, bilberry, grape seed, and pine bark extracts. It is a powerful flavonoid and antioxidant supplement that contains oligomeric proanthocyanidins (OPCs) that are 20 times more powerful than Vitamin C. This potent antioxidant supplement works to fight free radicals and associated damage and combat inflammation in the body. It is highly rated by users as an antioxidant supplement, but let’s take a closer look to see if it’s really worth the money in this Isotonix OPC-3 review.

Isotonix OPC-3 Bottle

Isotonix OPC-3 Benefits


Isotonix OPC-3 contains a powerful blend of antioxidants and flavonoids known as oligomeric proanthocyanidins (OPCs). These OPCs are 20 times more powerful than Vitamin C and 50 times more powerful than Vitamin E in neutralizing free radicals. Free radicals can cause damage to our bodies over time and can cause a great deal of inflammation, leading to preventable diseases. One powerful OPC included in the formula is Pycnogenol, a super-antioxidant that helps fight inflammation and fights free radicals.

Promotes Healthy Circulation

Isotonix OPC-3 contains powerful antioxidants that help fight inflammation and promote overall blood vessel health. Maintaining proper blood vessel health is essential for promoting healthy circulation. Also, free radicals often cause damage and destruction when it comes to our circulation, so taking an antioxidant supplement like Isotonix OPC-3 can reduce these free radicals and maintain proper circulation in the body.

Joint Support

These toxic free radicals that build up in our bodies can also cause joint damage. These free radicals can degrade the joint cartilage in our bodies and also cause inflammation, which can lead to a loss in joint flexibility/mobility and even joint soreness and pain. Taking Isotonix OPC-3 can help reduce these free radicals and joint inflammation, leading to ease of movement and greater flexibility.

Isotonix OPC-3

Isotonix OPC-3 Ingredients

The main ingredients in Isotonix OPC-3 include red wine, bilberry, grape seed, and pine bark extracts. These extracts make up bioflavonoids known as oligomeric proanthocyanidins (OPCs). These are all very potent antioxidants normally found naturally in certain fruits and vegetables. One specific OPC in this formula is Pycnogenol, which is a natural extract from pine bark trees. This is the only isotonic form in the world, and it is present in Isotonix OPC-3. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state. The Isotonix products are very beneficial as they exist in an isotonic solution, which allows for maximum absorption within the body and for nutrients to pass directly into the small intestine and then absorbed in the bloodstream.

These potent antioxidants of OPS are 20 times more powerful than Vitamin C and 50 times more powerful than Vitamin E in neutralizing free radicals. These extracts fight free radicals and thus reduce inflammation in the body. Inflammation is often the precursor to certain preventative diseases and can even cause a lot of cardiovascular and bone/joint issues. Isotonix OPC-3 works to reduce inflammation in the body, which can help maintain healthy cholesterol levels, support healthy blood vessel dilation, and regulates blood glucose levels.

The other ingredients are glucose, maltodextrin, and fructose, which are artificial sweeteners. These contribute 2 grams of sugar per serving. It’s definitely not necessary to have these artificial sweeteners in a product, especially as they can cause digestive issues and blood sugar irregularities. Try to stay away from these as often as possible.

Isotonix OPC-3 Ingredients

Does Isotonix OPC-3 Really Work?

Isotonix OPC-3 is highly rated as an anti-inflammatory supplement. Anti-inflammatory supplements are highly beneficial, but only if they are absorbed. Isotonix OPC-3 is a great supplement as it is highly absorbable due to its suspension in an isotonic solution, which resembles our blood and tears. The isotonic nature of this supplement also enhances its passing through to the small intestine and thereby promotes enhanced absorption into the bloodstream.

These extracts are also highly beneficial and have been proven by research to be powerful sources of antioxidants, bioflavonoids, and OPCs.

Who Should Use Isotonix OPC-3?

Isotonix OPC-3 is a great antioxidant and anti-inflammatory supplement. It’s a great product to take if you’re looking to reduce inflammation in your body. This could be a great supplement for someone looking for more joint mobility support, someone with cardiovascular issues, someone looking to combat typical signs of aging, and even for someone looking to regulate their blood glucose levels. Consult with your doctor before taking this supplement or if you have any questions about the particular ingredients.

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Is Isotonix OPC-3 Safe?

Isotonix OPC-3 is safe for use. It is an herbal blend of different bioflavonoid extracts. The biggest cause for concern with this product is the added artificial sweeteners. These can actually disrupt blood sugar levels and can have digestive issues associated with them. Be wary of these as they can lead to nausea, constipation, diarrhea, bloating, headaches, blood sugar irregularities, and have even be linked with diabetes.

Isotonix OPC-3 Alternatives

There are many different anti-inflammatory substances and supplements on the market. One of the best supplements and compounds is turmeric or curcumin. There are quite a few options, such as PuraTHRIVE Liposomal Turmeric and Smarter Nutrition Curcumin. Another great brand to try is Your Super Organic Turmeric Powder. It is a bit pricey, but it is a high-quality option with great reviews. Always be sure that piperine or black pepper extract is included in turmeric supplements for enhanced absorption.

Another great anti-inflammatory supplement is New Chapter’s Zyflamend. This supplement contains herbal ingredients like turmeric, ginger, and rosemary to help fight inflammation and provide antioxidant support. It is decently priced and highly rated by users.

Where To Buy Isotonix OPC-3

Isotonix OPC-3 is available directly from the Isotonix website for a price of $31.95 (30 servings) or $71.95 (90 servings).

Isotonix OPC-3 Website

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Alexa DaFonte

With a degree in Nutrition and Health Sciences from the University of Massachusetts Amherst, Alexa brings a vast knowledge of nutritional sciences, especially as it intersects with modern health and wellness. Due to her passion for a healthy lifestyle, she enjoys spreading awareness of the science behind many of her nutrition practices.