Omega XL Review – How Does It Compare?

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By Leslie Waterson

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


Omega XL is a supplement containing a combination of free fatty acids that support bone and joint health. It is specifically designed to help people with painful joints by combining Omega 3 fatty acids.

Constant joint pain can be challenging to live with. It can even be more difficult to find relief, as sometimes prescription drugs only cause further issues.

Finding an alternative supplement that does what prescription meds can’t do is something many living with chronic pain desire. But there are so many dietary supplements out there that claim to help. How do you know which ones are legit?

Today’s article brings you our Omega XL review as we discuss its ingredients and benefits, efficacy, cost per serving, side effects, and more. At the end of the review, we will let you know if we think Omega XL is worth the money or if you should purchase something else. Stay tuned. 

What is Omega XL?

What Is Omega XL

Omega XL is a daily nutritional supplement that helps relieve inflammation and joint pain.

It contains over 30 Omega 3 fatty acids derived from the green-lipped mussel, which is native to New Zealand. The extract from these mussels carries up to 22 times as many healthy fatty acids as fish oil.

When taking Omega XL (2 soft gel capsules a day), you won’t get any of the side effects you would typically see with fish oil, and you especially won’t have that unpleasant fishy aftertaste.

What Is Omega XL Good For?

Omega XL is suitable for any joint pain or inflammation. The combination of Omega-3 fatty acids has an anti-inflammatory effect that helps relieve pain in your body’s joints and muscles. Whether your pain is from workout soreness or everyday joint pain, Omega XL is designed to help you get relief.

Omega 3 fatty acids also support immune, skin, and heart health.

Omega XL Advantages

  • Reduce inflammation and pain in joints
  • Reduce muscle soreness
  • Improve organ function, especially heart and lungs
  • 30-day money-back guarantee on unopened products
  • No known significant side effects
  • Small, easy to swallow soft-gel



  • Paid spokespeople (e.g., Larry King) but scarce real customer testimonials
  • Only available online
  • No clinical trials published on the company website
  • Poor customer service
  • Canceling a subscription can be difficult

Who Makes Omega XL?

Omega XL Great HealthWorks

The company behind this “secret” to the relief of joint pain is Great Healthworks. It was started in 2003 by Ken Meares, both the founder and CEO, to give people quality dietary supplements so that they could better take care of themselves.

Omega XL was the first product they created to educate people about their health and how to practice “self-care.”

Since then, they have developed many other nutritional supplements for Men‘s Health, Women’s Health, Digestive Health, Antioxidants, Vitamins & Minerals, and much more.

Omega XL Ingredients


Omega XL contains a proprietary blend of:

  • Perna Canaliculus PCSO-524 (patented oil extract) – This is the proprietary blend, which is rich in Omega 3 fatty acids taken directly from the green-lipped mussels in New Zealand. It contains about 30 other fatty acids, including EPA, DHA, ETA, and OTA. All these free fatty acids reduce inflammation and joint pain and can also be good for the heart and the immune system.
  • Extra-Virgin Olive Oil – Aids in reducing inflammation and is believed to have anti-oxidative benefits.
  • Vitamin E – helps the body fight off free radicals to produce healthy red blood cells.

The company lists the total dosage of the fatty acids at 300mg but doesn’t list the dosage of each fatty acid, nor does it say the dosage of olive oil and vitamin E. As such, it can be difficult to accurately assess the effectiveness, quality, and safety of the ingredients in Omega XL.

Omega XL Dosage

The recommended dosage for Omega XL is two soft gels daily, preferably with a meal.

How Does Omega XL Work?

How Omega XL works is relatively simple. The Omega 3 fatty acids and other fatty acids work together to provide powerful anti-inflammatory aid to your joints and muscles, relieving any pain or stiffness in said joints and muscles.

It is believed that the fatty acids all work together to fight and relieve inflammation, specifically in the lipoxygenase (LOS) and cyclooxygenase (COX) pathways. It also competes with arachidonic acid for entry to said pathways. This effectively pushes agents that cause inflammation out of the way, so they don’t gain access to your joints or muscles.

Pain is significantly reduced by doing all of that to relieve inflammation.

How Long Does It Take For Omega XL To Work?

Limited customer reviews and general data on omega-3 fatty acids suggest that it could take weeks to months to see noticeable pain reduction.

Is Omega XL Safe?

Since all-natural ingredients are used, Omega XL claims to be extremely safe, even for those allergic to shellfish, milk, yeast, corn, or gluten.

That said, it is not recommended for use by women who are pregnant or nursing.

There are also no side effects, as stated on the Omega XL website, nor are there any known drug interactions. However, since there is little information about the fatty acids included and their dosage, it can be challenging to understand how someone might react.

As with any nutritional supplement, you should speak with your doctor before taking it if you have any concerns.

For those who have sensitive stomachs when it comes to taking dietary supplements, they recommend eating whenever you take your Omega XL dose.

What Are The Side Effects of Omega XL?

High-dose omega-3 supplements may cause nausea, stomach upset, diarrhea, or heartburn.

Where To Buy Omega XL


The only buying option on the Omega XL website is to purchase two bottles, a two-month supply. This usually costs $144, but they have an introductory price for first-timers of $39.95 plus $4.95 shipping.

If you buy from Great Healthworks, it’s $129.95 for 120 capsules unless you choose the subscription option, which gives you a 15% discount.

Does Omega XL Work?

It’s iffy, but we lean towards yes. On the one hand, Omega XL isn’t utterly transparent regarding its supplement formula, which can be cause for concern. On the other, they do include a high amount of Omega-3 fatty acids, which have been proven to help exhibit an anti-inflammatory effect on the body.

It can be hard to say if Omega XL will help your joint and muscle pain. We suggest you consider all the above information before buying this supplement.

Omega XL: Is It Worth It?

Omega XL is a powerful dietary supplement for easing joint pain and inflammation. We believe they are legitimate and not a scam based on what we’ve read.

However, the fact that they aren’t 100% transparent about what goes into the supplement’s formula and the fine print of their proprietary blend does leave us a bit concerned. That’s something to consider if you’re okay with before placing your order.

Since there are few customer testimonials on their website and only paid spokespeople, gauging whether or not this product does what it says is tricky. Their customer service leaves a lot to be desired, as well.

As such, we recommend caution in buying this product. Talk to your doctor first and see what they think before trying it.

Overall, we think buying Omega XL is a gamble you should only undertake if you can afford it.

Overall Rating:
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Leslie Waterson

Leslie has been passionately involved in the health and fitness industries for over a decade. She is constantly reviewing the latest scientific research and studies in order to take a research-backed approach to lifestyle optimization. Her main areas of interest include nutrition and supplementation. Leslie shares her findings on Fitness Clone to help other health enthusiasts choose the products and routines that will help them achieve their goals.