Best NMN Supplements

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

best nmn supplements

The demand for anti-aging supplements has risen in popularity lately. After all, as more and more people are living longer, they’re looking for ways to maintain health and vitality well into old age.

And even for people who are still relatively young, they’re hopping on the anti-aging trend with the goals of enhancing productivity, energy, and overall wellness.

Among all the anti-aging supplements out there, one of the most popular ones is NMN. Research has indicated that NMN may have key roles in energy, health, and anti-aging, which is why it may be beneficial for many different people.

In this article, we’ll go over the top NMN supplements to help you pick the best one for your goals, if NMN is something you want to try. 

Keep reading below, where we’ll jump right into our top 3 NMN supplements. 

Top Rated NMN Supplements

When choosing the top-rated NMN supplements, we paid attention to several important factors.

For example, we made sure that all of the NMN supplements had fully transparent labels and didn’t use any proprietary blends. Also, these top choices are all third-party tested for safety and purity.

In addition, our top NMN supplements had to include the proper doses for NMN and other ingredients (if applicable). 

With these things considered, we were able to come up with three NMN supplements that stand out from the rest.

Renue By Science

Best Overall

Renue By Science earns the top spot for best overall NMN supplement. They actually offer a line-up of several different NMN products, including NMN sublingual powder, capsules, tablets, and even topical sprays.

Each supplement provides anywhere from 250 to 500mg of NMN, which is a high dose to support NAD production. Some of the products also include NR and NAD to offer synergistic energy and anti-aging effects. 

All of the supplements are designed for optimal bioavailability too, such as the powder designed for sublingual use, their acid resistant capsules, or any of their other products which use a potent liposomal delivery system.

Lastly, every one of the Renue By Science NMN supplements are third-party tested and made in a cGMP, FDA-registered facility. 

renue by science nmn

Hello 100 Liposomal NMN+

Best Anti-Aging Blend

Hello 100 Liposomal NMN+ is the best NMN supplement specifically for anti-aging. This formula includes a solid 200mg dose of NMN per serving. And there are other powerful ingredients that offer anti-aging, anti-inflammatory effects such as resveratrol. 

On top of that, Hello 100 Liposomal NMN+ uses liposomal technology to enhance the absorption of the ingredients.

They take necessary measures for quality too as it is third-party tested, vegan, and made in a cGMP, FDA-registered facility. One bottle (30 servings) costs $79, although there are bulk savings available too.

hello100 nmn

Invity Ultimate NMN 12000

Most Potent

If you’re looking for the strongest NMN supplement, Invity Ultimate NMN 12000 is the best. It packs 400mg of NMN per serving for some of the strongest NAD-enhancing effects out there. 

But there are various supporting ingredients in this supplement that may also boost energy, reduce pain, and support metabolism, such as alpha lipoic acid, trimethylglycine, and Levagen PEA. 

Invity Ultimate NMN 12000 is vegan, third-party tested, and manufactured in a cGMP, FDA-registered facility. This one is definitely higher-priced though at $229 for 30 servings.

invity ultimate nmn

What is NMN?

NMN, which stands for nicotinamide mononucleotide, is a type of molecule called a nucleotide. It is used in the body by many different enzymes to produce NAD (nicotinamide adenine dinucleotide), which is a coenzyme important for overall health. 

For example, NAD impacts cellular metabolism, energy production, DNA repair, immune function, cellular balance, and other factors that are involved in maintaining healthy aging. 

But as you age, NAD levels tend to decline, which can lead to things such as lower energy, inflammation, joint pain, cognitive decline, and decreased endurance, among other things.

Therefore, NMN supplements are thought to have potential anti-aging effects due to their ability to restore NAD levels and/or prevent them from declining. 

NMN Supplements Benefits

There are various potential benefits of NMN supplements, all of which generally relate to the increase in NAD and cellular energy production.

It’s important to know that most research has been pre-clinical thus far. But there are some human studies too.

In general, NMN supplements may lead to:

  • Increased Energy
  • Better Metabolism
  • Decreased Inflammation
  • Improved Cognitive Function
  • Heart Support

Increased Energy

NMN is a precursor to NAD, which is involved in mitochondrial production and cellular energy. Thus, NMN may be able to enhance energy levels by boosting mitochondrial health and ATP production.

Users may notice physical and mental energy improvements. 

Better Metabolism

Some research shows that NMN can improve aspects of metabolism, such as insulin sensitivity, glucose tolerance, and fat metabolism. This may also help with weight management and fat loss.

Decreased Inflammation

NMN may also be able to decrease inflammation and oxidative stress due to its ability to decrease inflammatory cytokines and other markers of inflammation. 

As well, NMN can enhance immune cell function and seems to decrease inflammatory damage, especially in key areas such as the heart, brain, and kidneys.

Improved Cognitive Function

There are a few ways which NMN may improve cognitive function and brain health. First, NMN has anti-inflammatory effects which may reduce oxidative stress in the brain. Second, NMN can improve brain blood flow. 

Additionally, NMN can enhance energy metabolism and mitochondrial function in brain cells. Together, NMN could reduce aging-related cognitive impairments and may even have protection against Alzheimer’s and other brain disorders.

Heart Support

NMN may also offer heart support. Research has shown that NMN can reduce oxidative stress and inflammation in the heart. 

Plus, it may also enhance circulation and support blood vessel health and function. 

How to Choose the Right NMN Supplement

There are many different NMN supplements out there. That’s why it’s important to know how to choose the right ones so you can actually support your health goals rather than wasting hard-earned money on something that doesn’t work or has a questionable safety profile.

One of the things to consider when choosing an NMN supplement is the dosage. Generally, you want to find a product that has at least 150mg of NMN per serving, preferably 200mg or higher. At this dose, it’s more likely that you’ll experience actual benefits.

You also want to think about your specific goals. For example, if you want maximum NAD production support, you may want to look for products that include ingredients alongside NMN for that purpose, such as NR. 

Or perhaps you want a total anti-aging supplement. Which in this case, it’d be good to include various anti-inflammatory and anti-aging compounds alongside NMN, such as resveratrol, quercetin, or CoQ10.

With that said, many people simply want a pure NMN supplement too. And there are plenty out there that have NMN as the only ingredient.

Whatever supplement you want, it’s also important that you pick one that’s third-party tested and made in a cGMP, FDA-registered facility. This ensures that you’re taking in a safe, high-quality product. And the chance for side effects is much lower.

Additional Information (FAQ)

Listed below, we also have some additional information that’s important to help you best understand NMN supplements and how to use them for anti-aging or other health goals.

Does NMN really work for anti-aging?

No product is guaranteed to work. And there needs to be more clinical trials done on NMN. However, there definitely are many research studies that have shown explicit benefits of NMN, such as decreased inflammation, improved cognitive function, enhanced energy, and heart support. And these all point to a general anti-aging effect of NMN, mainly by enhancing NAD production.

Who should take NMN?

NMN supplements may be particularly useful for middle to older-aged individuals who want to restore NAD levels and possibly become healthier, more energetic, and to just feel “younger”.

But even young adults may want to supplement with NMN, especially as a preventive measure against aging. 

It’s not a fountain of youth. But NMN may offer anti-aging support at the very least.

Does NMN go well with other supplements?

NMN may have synergistic effects with other anti-aging ingredients, especially various antioxidants. For example, resveratrol, CoQ10, quercetin, and alpha lipoic acid may offer additional support for anti-aging and overall health. 

Can you get NMN from diet?

Yes. NMN is found in small amounts in various foods, especially fruits and vegetables such as cabbage, cucumber, broccoli, tomato, and avocado. However, the amounts present in food are much less concentrated compared to what you’d get from a supplement.

It’d be impossible to reach 200+mg of NMN from diet, which is why supplementing is much more practical. Of course, it’s still important to eat a healthy diet, which will naturally give you a little more NMN too.

Are there any side effects of NMN?

NMN is generally safe and shouldn’t pose side effects for most people. If side effects do occur, they’re generally mild, such as nausea, bloating, headache, or itchy skin. 

Keep in mind that NMN isn’t well-studied in humans. And it’s always best to consult your doctor before taking any supplement, especially if you have medical conditions and/or take prescription medications.

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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.