Best Longevity Supplement – 3 Top Picks

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By Jack Cincotta, MS

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

best longevity supplements

The search for that holy “fountain of youth” has existed essentially ever since we’ve been around as humans.

After all, the notion of being able to live longer by consuming some miracle elixir is very intriguing.

Of course, it doesn’t seem like we’ll find such a compound any time soon (or ever, for that matter). Sorry to burst your bubble!

However, there definitely are some ingredients and compounds out there that can support longevity and boost your overall wellness.

In fact, many supplements on the market today are advertised to support longevity and health. And in this article, we’re covering the best ones so you can have a better idea of what to take to boost your health and support longevity. 

Keep reading below to find out what these supplements are and how they may benefit you!

Best Longevity Supplements

The top three longevity supplements we’ve come across here at Fitness Clone are:

  • Verso Cell Being
  • Renue by Science NMN
  • Renue by Science Trans-Resveratrol

Make sure to read the entire article as we’ve also included some bonus supplements that further assist longevity and overall health. 

Verso Cell Being

Best Blend

The best anti-aging blend we’ve come across is Verso Cell Being. This formula contains a powerful 3-in-1 combo of NMN (at 250mg), trans-resveratrol, and trimethylglycine. These work together to boost NAD production and in turn promote cellular energy capacity, DNA repair, and systemic anti-aging effects. 

Verso Cell Being is also made in the USA in a cGMP facility and third-party tested to ensure product potency and purity. 

The regular price is around two bucks per serving, but you can save significant money by choosing one of their bulk options.

verso cell being

Renue By Science NMN

Best NMN

If you’re looking for a pure NMN supplement, Renue By Science’s NMN line has you covered. They offer several different NMN products, from tablets, to capsules, to powder. Depending on the product, you’ll get anywhere from 250 to 500mg of NMN per serving, which is a solid dose to boost NAD and mitigate the natural NAD decline that occurs during aging.

Also, whether you get the fast-dissolving tablets, liposomal capsules, or quick-dissolve powder, each product is designed for optimal bioavailability and absorption.

Plus, Renue By Science NMN products are all third-party tested and verified during several steps of the manufacturing process.

renue by science nmn

Renue By Science Trans-Resveratrol

Best Resveratrol

Renue by Science Trans-Resveratrol is the best resveratrol supplement, due to its high potency and bioavailability. It comes either as a fast-dissolving powder or liposomal capsules, which are both designed for superior absorption. And this may lead to even great anti-inflammatory and anti-aging effects that are known to occur with resveratrol.

You get 500mg of resveratrol per scoop, or 125mg per capsule. So the powder is definitely more cost-effective, but both are solid options.

 Renue by Science Trans-Resveratrol is also third-party tested for safety, purity, and potency. 

renue by science trans resveratrol


Longevity is obviously a complex issue with many factors involved. And while the three we listed above are some of the best supplements to directly target longevity, there are also many other kinds of supplements that can support healthy aging.

In particular, three other supplement categories that may have a positive impact on health and aging are multivitamins, collagen, and probiotics. 


Multivitamins can potentially offer anti-aging effects by giving your body the micronutrients it needs to function optimally on a daily basis.

Deficiencies in vitamins, minerals, or other micronutrients can lead to suboptimal functioning in literally every part of the body, depending on what micronutrient it is. And in today’s world, many people have a hard time getting enough nutrients, due to processed food, soil depletion, high stress, and several other factors. 

Even if you eat a really healthy diet, it’s very likely that it’s not as nutrient-dense as the same diet from 100 years ago, due to some of the factors mentioned.

This is why multivitamins help. They cover your bases to offer general support for heart health, brain function, bone strength, immunity, metabolism, and other key factors related to aging and wellness. 

There are many choices out there, but one of the best multivitamins for longevity is Manna Liposomal Multivitamin. It contains 21 vitamins and minerals plus 11 extracts from fruits and vegetables. And the liposomal delivery offers superior bioavailability. 


Another ingredient that can support longevity is collagen. This substance makes up 30% of the body’s protein. It’s found in connective tissues and the hair, skin, nails, joints, and other areas. 

As we age, collagen production naturally declines, which can lead to things like joint pain, wrinkles, brittle nails, and thinning hair.

And we used to get collagen naturally from the diet by consuming things such as bone broth. But hardly anyone ever eats these “nose-to-tail” foods anymore and thus don’t consume any collagen.

Fortunately, collagen products are an easy way to boost collagen production and synthesis to give you fuller hair, healthier, more vibrant skin, stronger and more flexible joints, and other aspects that contribute to a younger “you”. 

One of the best collagen supplements out there is Vital Proteins Collagen Peptides, which has 10g of collagen per scoop, along with added support from vitamin C and hyaluronic acid. 


Probiotics are also important for longevity mainly because of their impact on gut health. These good bacteria can restore but microbiome balance and optimize several aspects of gut function.

In turn, this may lead to other health benefits since the gut is connected to other areas, such as immune function, metabolism, and even mental well-being. 

Arguably the most comprehensive probiotic out there is Seed Synbiotic, which contains 24 strains of probiotics along with prebiotic fiber for additional gut health support. 


What are Longevity Supplements?

The term “longevity supplement” is very broad. But in general, this refers to any supplement that is designed to promote anti-aging effects, either directly or indirectly. 

The aging process is characterized by a number of issues, such as lower energy, joint pain, brain fog, low sex drive, skin, hair, & nail issues, poorer exercise performance/endurance. Not to mention aging generally increases the risk of various health issues, such as heart problems, cognitive disorders, metabolic dysfunction, and bone and joint problems, to name a few.

Aging can’t ever be fully stopped, of course. But people use longevity supplements to slow down this natural process, which may also mitigate some of these issues.

As you’ve seen from above, many anti-aging supplements, such as NMN, try to target NAD, which is a key compound involved in cellular energy production and DNA repair. And since everything in the body starts on a cellular basis, this is designed to turn back the clock on cellular function, leading to systemic benefits.

Otherwise, there are many other anti-aging ingredients that are designed to reduce inflammation, boost nutrient intake, and ultimately give the body the ingredients it needs to maintain tip-top shape as long as possible. 

Benefits of Longevity Supplements

The potential benefits of longevity supplements are vast. But it’s also important to remember that no benefits are guaranteed. And as of yet, there certainly isn’t a cure-all or true fountain of youth. 

With that said, some of the benefits that may occur from longevity supplements are:

  • Increased Energy
  • Improved Brain Function
  • Heart Support
  • Boosted Athletic Performance
  • Better Sleep
  • Decreased Inflammation & Pain
  • Immune Support

Increased Energy

Longevity supplements may lead to increased energy, particularly if they include NMN or other ingredients designed to boost NAD production. This may lead to enhanced cellular energy production, which can lead to greater physical and mental energy as a whole. 

In addition, compounds such as B-complex vitamins, magnesium, and iron may also enhance energy production, especially if one is deficient in these. 

Improved Brain Function

Anti-aging supplements may also lead to improved brain function and cognitive performance. For one, this could be due to various anti-inflammatory ingredients, such as resveratrol, which can decrease brain inflammation.

Plus, NMN can activate energy production in the brain, leading to sharper cognition and focus. And sometimes, longevity supplements also include various herbs, vitamins, and minerals (e.g. B-complex vitamins, zinc, lion’s mane) that may improve brain cell function and overall brain health. 

Heart Support

Longevity supplements may also contribute to a healthier heart and circulatory system. The various ingredients found in these products can control inflammation in the heart, boost the strength and energy production of heart cells, and possibly enhance blood flow and circulation. 

In terms of micronutrients, getting enough vitamin D, vitamin K, calcium, and magnesium seem most important. 

Boosted Athletic Performance

Another possible benefit of anti-aging products is boosted athletic performance. Decreased NAD, lower levels of certain hormones, and other factors can lead to poorer endurance and exercise performance. 

But NMN, TMG, certain vitamins and minerals, and other compounds in longevity supplements may assist exercise performance by ramping up energy production in the muscles, lungs, nervous system, and other areas involved in exercise. 

Other ingredients like collagen may even support exercise recovery and joint support.

Better Sleep

It’s very common for people to have trouble sleeping as they get older. The effects of NMN and other longevity compounds may enhance NAD levels, which could lead to healthier, more restorative sleep that you achieved in your younger years. 

Plus, taking certain supplements to correct deficiencies, such as magnesium or vitamin D, may also improve sleep quality. 

Longevity Supplements For Better Sleep

Decreased Inflammation & Pain

Longevity supplements may also decrease inflammation and oxidative stress, which are two hallmarks of aging. Resveratrol, curcumin, vitamin C, vitamin E, and many other anti-inflammatory agents are often found in these products, which can work to reduce oxidative stress in many areas of the body.

And since inflammation is connected to pretty much every chronic disease, this may also lead to a reduced risk of various health problems, not to mention less pain too.

Immune Support

Anti-aging supplements could offer immune support. Some of the anti-inflammatory effects mentioned above may also be beneficial for immune health. 

NMN may be able to improve the efficiency of immune cells. And a number of other ingredients, such as vitamin D, vitamin C, resveratrol, and zinc may also improve immune health.

Healthier Skin, Hair, & Nails

Lastly, longevity supplements may also offer benefits for hair, skin, nails, and overall appearance. NMN may help slow down accelerated skin aging. And another common ingredient used is collagen, which can support the health and strength of hair, skin, nails, and even the joints. 

Possible benefits are decreased wrinkles, more hydrated skin, fuller hair, and stronger nails.

How to Choose the Best Longevity Supplement

As we mentioned, longevity supplements are a very broad category. And with so many potential products out there, it can be overwhelming to try to find the right one. But this section helps you identify which supplement is best for you.

Now, one of the most important things to consider is your goals. For example, you want to think about how general or specific your desired benefits are, how comprehensive of a supplement you want, and if you want to use just one or more products.

For people who just want one, general anti-aging supplement, NMN-based products are great choices. 

Additionally, compounds such as resveratrol, CoQ10, and other antioxidants are great additions to support longevity and overall wellness.

And as you’ve seen, you can also include a multivitamin, probiotic, and/or collagen supplement as these also provide further support for longevity and overall health and wellness. 

Regardless of the supplement (s) you choose to buy, it’s also important that they are:

  • Made in cGMP, FDA-registered facilities
  • Ideally third-party tested
  • Aligned with your dietary restrictions/preferences
  • Fully transparent (with the label/doses)

Also, consider how you want to take your supplement. Do you like taking pills, powder, capsules, or maybe even a liquid?

With so many choices out there, it’s likely that you’ll find a product that has your desired product form. 

Additional Information (FAQ)

This section provides additional information on longevity supplements, including answers to some of the most common questions.

Do longevity supplements work?

Overall, yes. However, individual results can and will vary. And as we’ve mentioned, there isn’t any supplement that’s a true fountain of youth or miracle pill. With that said, there certainly are plenty of high-quality longevity formulas out there now that may help slow down the natural aging process and lead to various health benefits. 

How long do I have to take anti-aging supplements?

For best results, most anti-aging supplements likely take at least a couple months. You can take most of these products indefinitely, and it seems that the benefits may stop when you stop taking them (especially for NMN). So, long-term, continued use seems ideal.

What if I already have a healthy diet and lifestyle? Do I really need these?

We’ll hardly ever say that you 100% NEED a supplement. And a healthy diet and lifestyle certainly go a long way in keeping you healthy. In particular, getting enough sleep, eating a nutrient-dense diet, daily exercise, stress management, and social connection are all great things you can do on a daily basis to boost health and support longevity.

With that said, aging tends to take its toll over a long enough period of time. And these supplements may provide additional support for longevity, even if you already have a healthy diet and lifestyle. Again, we’re not saying that adding these products will make you live to 110. Bu they do seem to provide anti-aging support, especially if you use individualized supplements targeted to your own unique needs and concerns. 

Are longevity supplements safe?

The safety profile differs depending on the ingredients involved. But in general, the ingredients we’ve looked at are safe for most people to consume in regular amounts. 

NMN and other NAD-boosting ingredients may cause nausea, diarrhea, stomach discomfort, flushing, and other symptoms when taken in high doses.

More generally, other ingredients in these formulas may have side effects such as:

  • Headache
  • Allergic reactions
  • Trouble sleeping
  • Drowsiness
  • Mood changes

This isn’t an exhaustive list. Always contact your doctor before taking any supplement. 

Are longevity supplements worth the money?

Longevity supplements can get pretty pricey, especially some of the NAD-boosters. So, whether it’s worth it ultimately depends on your current health situation and the benefits that you experience.

For a younger individual who doesn’t have many issues and only notices slight benefits, it may not be worth it.

But for an older person who has a variety of aging symptoms and ends up experiencing several noticeable benefits, then it’s likely worth it. 

So, it just depends on a few factors. We can’t say that it’s always worth the money, nor will we say that it’s never worth it either!

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Jack Cincotta, MS

Jack Cincotta is a certified holistic health coach through AFPA and a board-certified holistic health practitioner through AADP. He has written hundreds of articles on nutrition and supplementation. Jack has a M.S. degree in Psychology and is passionate about researching the science behind nutrition. He often uses research-backed supplementation protocols for many of his clients to optimize results.