Active Stem Review – Is This Supplement Effective?

Photo of author

By Juliana Tamayo, MS, Nutritionist

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


At Fitness Clone, we have reviewed hundreds of different supplements. Our reviews have covered the waterfront in supplementation, from protein powders to weight loss supplements, pre, and probiotics to enzymes and cognition products.

Now we enter an exciting new realm, one of the most interesting and promising medical discoveries in years, stem cell therapy. Stem cells are the driving force in regenerative medicine and the regenerative therapy field.  

Today, we will be looking at a product called Active Stem.

We will delve into the details of the company, Live Cell Research, LLC (LCR Health), and the product Active Stem. Before that, though, we will discuss the science of stem cells in greater detail. If you are going to use a product like Active Stem, you should understand the science behind it.

So, let’s dive into this Active Stem review and learn more about this product and the research surrounding it!

Active Stem

Stem Cells – Miracle Treatment

Stem cells and stem cell therapy have been called the miracle treatment. It is no wonder that stem cell research is becoming increasingly popular. These “master cells” are cells that develop into blood, brain, bones, and the body’s organs. Researchers believe they could be used to treat a myriad of medical conditions with the potential to repair and regenerate diseased cells. You can think of stem cells as “repair systems” for the body, and stem cell therapy is used to improve your health from a few different angles.

Although there is a great deal of optimism regarding stem cells and regenerative medicine, there is still considerable debate in the medical community as to the effectiveness, applications, and source of cells. The FDA is responsible for regulating stem cell products in the U.S., and to date, it has only approved one product, used in forming blood cells. 

The three primary sources of stem cells are embryonic, adult stem cells, and Induced pluripotent stem cells iPSCs from adult stem cells. Embryonic cells can become any type of cell, while adult stem cells are specific to a certain kind of tissue. iPSC cells are adult cells that have been reprogrammed in a laboratory setting so that they can become another type of tissue. 

There are an incredible number of ongoing clinical studies in the stem cell and regenerative medicine field, and we anticipate many more discoveries and applications.

Active Stem Product Maker

Live Cell Research, LLC – dba LCR Health

Per our standard procedure, we researched the company as well as the product. LCR Health is the dba (doing business as) name of Live Cell Research, LLC. The company, headquartered in Woodland Hills, CA, manufactures supplement products primarily targeted at anti-aging at the cellular level, including Active-PK, Telogenesis, Prime ATP, and the subject of our review Active Stem.

Although we were unable to ascertain the founder of LCR or the ownership, we were introduced on their site to its Chief Medical Officer, Dr. Rand McClain. In the About Us section of the website, Dr. McClain speaks of his twenty years in regenerative medicine.

Ironically, this writer was familiar with Dr. McClain as a frequent contributor to the magazine Max Sports & Fitness, the in-house publication of Anaheim, CA-based Max Muscle Sports Nutrition franchisor. Dr. Rand McClain currently operates a Regenerative & Sports Medicine office in Santa Monica, CA. 

Active Stem Product Doctor

In this Active Stem review, we will detail what the Active Stem product is, and what it is not. Unlike other Active Stem reviews, we will take a close look at the product formulation and key ingredients, but we will also discuss the product’s purported features and benefits and investigate to determine if the product is meeting its marketing claims. We will inform you where you can find the product, review the cost-value relationship, and always provide our rating in terms of effectiveness and value. In other words, we are looking at the whole picture of this product, and whether it truly stands out among the stem cell supplements. 

What Is Active Stem?

Active Stem is a powdered supplement described by the company as, “a cutting-edge blend of 5 powerful ingredients which, in clinical studies, have been shown to boost adult stem cell proliferation in vitro.”

Active Stem Bottle

Let us be clear, LCR Health Active Stem is a supplement containing Vitamin D and a proprietary blend of L-Leucine, Blueberry Fruit, Green Tea Leaf Extract, and L-Carnosine. Active Stem does not contain stem cells or stem cell precursors. 

The supplement is designed to combat aging at the cellular level in order to boost energy, improve cognitive function, maintain strong joints and muscles, and support an active lifestyle.

This stem cell supplement product comes in both powder and capsule form. It is also gluten-free, with no soy or dairy. The company states that all ingredients are independently tested by a third-party facility and offers an “Ironclad” 90-day money-back guarantee. 

Active Stem Key Ingredients

Active Stem is formulated with a simple blend of a few key ingredients.

Active Stem Ingredients

Vitamin D, 50 mcg (micrograms)

Vitamin D supports the absorption of calcium, magnesium, and phosphate in the body. It also plays an essential role in the development of bones and teeth. Vitamin D may help address the softening of the bones, bone loss, and osteoporosis.

However, it should be noted that unless you are vitamin D deficient, supplementation is not necessary. That said, more and more research is being released on the importance and benefits of vitamin D and many individuals will benefit from supplementation. The truth is that vitamin D is essential for healthy brain function, bone marrow strength, and even glucose homeostasis. While you might not need this vitamin, most Americans tend to be deficient in it. 

Proprietary Blend 1,400 mg

If you have previously read our reviews, you understand our dislike of proprietary blends, which do not specify the quantity of each ingredient in the blend. A proprietary blend is not necessarily a “red flag” though. Many companies use proprietary blends to protect their formulations so competitors cannot copy their products.

Still, proprietary blends do not provide full transparency, which makes it more difficult for us to review the effectiveness of a supplement.


This is a branched-chain amino acid frequently found in sports nutrition products, typically in a 2:1: ratio with L-Valine and L-Isoleucine. Studies indicate that L-Leucine plays a role in protein synthesis and can be beneficial in retaining lean muscle.

Blueberry Fruit

Blueberry contains high levels of vitamin C and other antioxidants known to fight free radical damage. Vitamin C is also essential in the absorption of iron and the creation of collagen, all of which can help keep you feeling young and energized. 

Green Tea Leaf Extract

Green tea contains caffeine, which can boost mental alertness, reduce brain fog, and give you energy balance. Green Tea is also high in antioxidants and may help prevent inflammation. This ingredient may also help with weight management.


This is a dipeptide molecule made up of two amino acids, beta-alanine, and histidine. You can find it in muscles, the heart, brain, liver, and kidneys.

Active Stem Supplement Powder

Active Stem Ingredients: Final Verdict 

In our opinion, these ingredients are common in many other supplements, but they have might be able to meet some of the Active Stem claims.

However, there is no strong evidence that these ingredients can promote stem cell support. More research needs to be done. That said, there is sufficient evidence to show that these ingredients may help boost energy, improve cognitive function, and provide some anti-aging benefits (due to the antioxidants). 

Active Stem Supplement Bottle And Powder

Active Stem Benefits

On the LCR Health website, the company claims that Active Stem can:

  • Combat cellular aging
  • Boost natural energy
  • Support cognitive function
  • Support strong joints and muscles
  • Support a stronger, more active body

It is likely that the supplement can follow through on most of these benefits. Let us address them one by one and discuss how the ingredients may contribute to the claimed benefits.

Reduce Cellular Aging 

All of the ingredients in Active Stem may combat cellular aging to some degree. The formulation contains antioxidants and other ingredients that may improve cellular health.

LCR Health Active Stem combines blueberry fruit, green tea leaf extract, L-Carnosine, and vitamin D all of which play a role in cell function and reduce the risk of cell damage. 

Improve Energy Levels and Boost Cognitive Function 

For the most part, green tea extract may help boost natural energy and support healthy cognitive function. This ingredient, along with blueberry, can make you feel more alert and focused.

Support Muscles and Joints 

Vitamin D and amino acids (L-leucine and L-Carnosine) can help support strong joints and muscles. It is common for athletes to take branched-chain amino acids for recovery and performance.

Active Stem Benefits: Final Verdict 

Overall, Active Stem offers quite a few benefits, the main ones are the energy boost and the protection from free radical damage thanks to the inclusion of antioxidants.

Nonetheless, as you might notice from other Active Stem customer reviews, the extent of the benefits is debatable. Still, you will not do any harm in trying this product. 

Recommended Dosage of Active Stem

The company’s recommended dosage for Active Stem is one scoop per day (3.9 grams) with 16 ounces of water. You could also mix the powder into another beverage of your choosing.

Additionally, Active Stem may be taken with food or on an empty stomach.

Active Stem Label

How Does Active Stem Perform?

As mentioned above, Active Stem delivers on a few of the main benefits claimed by the company. It can help boost your energy, improve mental performance, and fight free radical damage.

Just like promoting stem cell proliferation and/or regeneration, this is a bold claim that is difficult to test. We have to rely on the research, which is not conclusive.

The company is run by a specialist in regeneration and they cite a few studies that support their findings. We are looking forward to more research in this area so we can better gauge the effectiveness of Active Stem in this area.

Scientific research aside, Active Stem reviews are overwhelmingly positive. Users report the following benefits:

  • Increased energy
  • The disappearance of aches and pains
  • Increased mental alertness
  • Healthier skin and nails
  • Weight loss

Granted these are customer reviews posted on the company’s official website and the results will vary by individual.


Is Active Stem Safe?

The main question is does Active Stem work? While that might be up for the debate, its safety is not.

The ingredients and dosages found in Active Stem should not cause any adverse side effects. As always, we recommend you consult with your medical professional before starting any new supplement. 

Where to Buy Active Stem

The best place to buy Active Stem is on the official company website.  The product sells for $69.00 per tub and each tub contains 30 servings (a 30-day supply).  You can use this link to get your first tub for $46.99 ($22 off).

Buy Active Stem

Further savings are available if you stock up in advance. You can get three tubs for $117 ($39/tub) or six tubs for $214.27 ($35.71/tub).

You can also choose to subscribe for an auto-ship plan to save an additional 10% on any package. Subscriptions also come with the benefits of free shipping, price stability, and guaranteed availability. You can cancel your subscription at any time.

Every purchase is backed by a 90-day money-back guarantee. If you are unhappy with the product, you can send it back within the first 90 days and get a full refund. This is an important guarantee for a product like Active Stem since people will go in with different expectations. We respect that the company offers a money-back guarantee. It shows they believe in the product and cares about customer satisfaction. 

Active StemSave up to 24% on Active StemWe scour the web for the best deals on supplements. Want to save up to 24% on Active Stem? Click the button below to get this deal!GET THE DEAL

Final Thoughts: Active Stem Review

Overall, Active Stem is a well-formulated supplement that offers a range of health benefits.

Active Stem ingredients can help increase energy levels, slow down the aging process, and strengthen your muscles. We have a hard time classifying this product as a “stem cell booster” because the research is inconclusive.

That said, the product does deliver on the promoted benefits and it is backed by a 90-day money-back guarantee. Customer reviews cite an impressive list of health benefits so this product may be worth trying if you’re looking for an anti-aging supplement that can boost energy levels.

Take a chance and try this product. As a dietary supplement it is accessible and easy to take, and you can always get your money back if you do not like it! 

Overall Rating:
Photo of author

Juliana Tamayo, MS, Nutritionist

Juliana Tamayo is a registered dietitian with a Master of Science in Nutrition, Dietetics, and Sensory Sciences from the Kansas State University. She also has a B.A in Journalism and Creative writing, and lives in Washington, D.C. where she works as a part-time writer and editor and clinical dietitian. Juliana has experience covering all sorts of health and nutrition topics, including chronic illnesses, medicine, cooking, fitness, alternative healing, and more.