Tru Niagen Review – Does This Anti-Aging Supplement Work?

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By Leslie Waterson

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


Although no one can live forever, many of us do crave the capacity to live longer and experience healthy aging. It is critical to differentiate the quality of life as we age than simply extending life. Hence the Niagen tagline “Age Better,” and why this Tru Niagen review can serve you well in deciding whether this supplement is for you or not.

Tru Niagen Anti-Aging Supplements

Nearly one in seven, or 15% of America’s population, is 65 or older. The trend will continue as this number is projected to double in the next decade. Given these trends, it is no wonder anti-aging is big business. 

The size of the market varies based on which studies you quote, anywhere from $66 billion to an estimated $216 billion by 2021. The studies are different due to the definition of the market: topicals, surgical procedures, hormone replacement therapies, pharmaceuticals, and supplements. 

Researchers continue to search for the proverbial “fountain of youth.” Telomeresantioxidants, the CR (Calorie Restriction) dietRapamycinMetformin, and anti-inflammatories are all under investigation. However, one of the latest items getting a massive amount of attention is NAD. 

Enter Tru Niagen, who self-proclaims as the foremost authority on NAD. Read our Tru Niagen review to find out if this supplement you were looking for.

Tru Niagen

What is Tru Niagen

Tru Niagen is an anti-aging dietary supplement, featuring the patented ingredient Niagen (nicotinamide riboside chloride). The product is distributed by ChromaDex, Inc. To quote the Tru Niagen website:

“We use NAD every day for basic functions like sleeping, breathing, eating, and drinking. But our NAD levels decline over time and under stress, which contributes to changes in health. Tru Niagen increases your NAD, every time you take it.”

The statement quotes the standard disclaimer that, “These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

The site states that:

  • There have been more human trials using Niagen than any other form of NR
  • The FDA has done three separate safety studies on the ingredient
  • ChromaDex has conducted more than 100 preclinical studies

Two comments of note that lend to the credibility of Tru Niagen:

  1. ChromaDex has done the right thing and registered Niagen with the FDA, receiving their New Dietary Ingredient status. Far too many supplement companies skip this crucial step.
  2. ChromaDex has also received NSF’s Save for Sport seal. This third-party certification ensures the product contains no banned substances.
Tru Niagen Bottle And Pills

So, what precisely is NAD?

Through our reviews, we aim to make complicated science a little more attainable for everyone. With that in mind, NAD is one of those topics that might sound complex. Per NAD (nicotinamide-adenine dinucleotide) is a coenzyme that is involved in many biochemical oxidation-reduction reactions. 

In this instance, the ChromaDex explanation is probably the most natural and most accurate …

we use NAD every day for basic functions.” 

NAD supplements are increasingly popular and Tru Niagen is one of the leading options right now. Let’s take a closer look at the ingredients so we can better understand the health benefits.

Tru Niagen Supplements- Key Ingredients

The only active ingredient in the product is Niagen (nicotinamide riboside chloride), 150 mg per capsule.

However, the recommended dosage is two Tru Niagen capsules or 300 mg per day. The only other items listed on the Supplement Fact sheet are the components of the Vegetarian capsule.  

Unlike what people think and other supplements, these capsules are caffeine-free and contain no artificial flavors.

Tru Niagen Supplement Facts

Just a Bit of Chemistry

Nicotinamide riboside (NR) is a form of vitamin B3 that acts as a NAD precursor or nicotinamide adenine dinucleotide or NAD+.

When NR is used as a chloride, as in the Niagen patented ingredient, it delivers 88 mg of NR per 100 mg of Niagen. In effect, you are receiving 264 grams of NR per day in the Tru Niagen supplement. 

Vitamin B3 is also known as niacin, niacinamide, or nicotinic acid. B3 is one of the vitamins comprising what is known as the vitamin B complex.

For many years, B vitamins have been common dietary supplements to reduce metabolic stress and promote better health outcomes.

Benefits of Tru Niagen

The true benefit of Tru Niagen is to allow you to do those things you enjoy longer. It does this by giving your cells the NAD they need to generate energy levels.


NAD has been studied in several clinical studies as a potent antioxidant. It prevents cellular damage caused by free radicals 

Heart Health

The main ingredient in Tru Niagen, NAD supports healthy cholesterol levels as well as reducing blood pressure. In turn, NAD can also be good at reducing the risk for heart disease.

Cellular Health

NAD also promotes cellular metabolism and enhances cellular energy.

Reduce Brain Damage and Metabolic Stress

Since NAD is great at deterring oxidative stress, it might help prevent age-related brain degeneration and improve cognitive function.

Other Benefits

Aside from slowing down the aging process, some of the health benefits of Tru Niagen include possible protection against liver disease and liver cancer, promote cellular repair, and improve overall well-being.

Tru Niagen Supplement

Who Needs Tru Niagen?

Today, more people look at the anti-aging market as a preventative strategy. Tru Niagen is ideal for anyone interested in extending their active years and aging gracefully. 

It can also be beneficial for people over forty who are looking to increase their energy. Clinical trials have shown that more than healthy aging, NAD can promote energy production by boosting NAD levels that then leads to better overall health.

Anyone who feels fatigued, tired, or has concerns about the negative effects of aging, can try taking Tru Niagen.

Tru Niagen Dosages

A bottle of Tru Niagen contains 60 capsules, a 30-day supply if used as recommended. Each capsule contains 150mg of Niagen’s nicotinamide riboside chloride. Users should take two capsules in the morning with or without food.

Does Tru Niagen Perform? 

Since we have covered the science, now it is time to talk about what users are saying about this product.

At the time of writing, there were over 518 reviews of Tru Niagen on Amazon. More than half of the reviews have a 5-star rating. The benefits we saw most frequently were energy and improved sleep.

The most common complaint of responders was not seeing any immediate benefit from the product. 

Nonetheless, Tru Niagen uses proven ingredients and is one of the leading NAD supplements on the market.

Tru Niagen Pills

Potential Side Effects of Tru Niagen

As with any vitamin, supplement, or product, there are potential side effects.

That said, this product is essentially a form of Vitamin B3, and we found very little evidence of people experiencing side effects. Many people will experience a niacin flush with certain B-vitamins. Still, nicotinamide riboside (NR) supplements do not appear to be a trigger.

Some potential side effects include:

  • Nausea
  • Dizziness
  • Headaches
  • Diarrhea
  • Indigestion

For the most part, these will disappear as your body gets used to it. However, older adults might experience increased side effects.

As always, we suggest you check with your doctor or health care provider, particularly if you have any pre-existing conditions, like lower blood pressure or tend to do intense exercise.

Is Tru Niagen Safe?

So far, all clinical trials point to the fact that this supplement is safe. It contains no additives, artificial ingredients, or anything else. The capsule also happens to be vegan, so anyone with dietary restrictions can take it.

But is Tru Niagen FDA approved? No, but no other supplement is. FDA approval does not happen for any dietary supplement, but certain products follow the scientific community. Tru Niagen is a leader in this area and continues to use more research and human studies every day.

Nonetheless, the company’s lead scientist, Dr. Charles Brenner has led the journey into NR as a supplement for cellular function. NR will raise NAD blood levels, improving cellular energy production without causing any metabolic stresses.

You should follow the recommendations, such as taking Tru Niagen once or three times a day with or without food. Within a few weeks, you should see some benefits, particularly as it pertains to your overall health.Tru Niagen

Best Places To Buy Tru Niagen

The number one place where most people purchase the product is the Tru Niagen website.

There was no store locator on the official site, so it was difficult to determine if the product is available in any brick and mortar locations.

Authorized distributors of NR products listed on the website include:

  • NiaCel, from Thorne Research 
  • NAD+ Cell Regenerator™, from Life Extension 
  • N(R) Capsule NAD+ Booster™, from HPN

Although Tru Niagen is the only product using the patented Niagen as an ingredient, there are many other brands that offer a nicotinamide riboside (NR) product.  

Tru Niagen In Hand

Tru Niagen Pricing

The official Tru Niagen site offers several ways to purchase the product, incentivizing consumers to buy more than a single bottle for $50.00.

Three months go for as low as $35.00 / bottle, and a six-month supply is $30.00 per bottle.

There is, of course, the Auto-Ship program, in which you receive a bottle every three months for $35.00 per bottle.

Tru Niagen Bottle In Box

Even though they offer a 30-day money-back guarantee, we think it is a bit limiting because it only accepts unopened and intact products. For the most part, you will also receive your money back if you regret the purchase but not if you dislike the product.

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Tru Niagen Review: In Summary

How does anyone know if their cellular function is healthy? How do you know if your NAD levels are improving?

If you seem to have more energy, that is a good thing. If you are sleeping more soundly with more REM cycles, those are good things. 

We think there has been sufficient testing, and enough positive reviews, to argue that Tru Niagen is worth a test run. Promoting cellular repair and more energy levels is possible when you improve NAD levels too, and that is exactly what this supplement promises to do.

Cellular health depends on nicotinamide riboside chloride because by giving it to your body, you will improve NAD levels at the cellular level.

Although we cannot provide medical advice, we believe that Tru Niagen is generally recognized as a superior supplement thanks to its potential benefits and more than one clinical trial.

Consider improving your energy metabolism and raise NAD levels by taking this supplement. Start taking Tru Niagen once or twice a day and see how your well-being improves within a few weeks.

Overall Rating:
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Leslie Waterson

Leslie has been passionately involved in the health and fitness industries for over a decade. She is constantly reviewing the latest scientific research and studies in order to take a research-backed approach to lifestyle optimization. Her main areas of interest include nutrition and supplementation. Leslie shares her findings on Fitness Clone to help other health enthusiasts choose the products and routines that will help them achieve their goals.