Rootine Vitamins Review – Are Personalized Vitamins Worth The Money?

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By Juliana Tamayo, MS, Nutritionist

Reviewed by Juliana Tamayo, MS, RDN - Last Updated

rootine review

Everyone knows that essential vitamins play a key role in nutrition. However, you are probably getting bombarded with a personalized vitamin regimen to add to your dietary routine. 

That is exactly where Rootine comes in. These custom vitamins focus on certain nutrients that your diet might be lacking. If you are on the fence about your next multivitamin, then take a look at our Rootine vitamins review and learn about this company and product. You will see every vitamin brand differently after learning about this supplement.

About Rootine 

Over the past few years, personalized vitamins have become increasingly popular. Scientists and nutritionists recognize that every individual is unique, and a “one-size-fits-all” vitamin may not be the most effective solution.

Rootine is one of the newer personalized nutritional supplement manufacturers to catch our attention. They customize each product they ship to meet the unique needs of every individual customer.

rootine health products

Rootine’s vitamins are shipped in single-serve sachet packets with the customers’ names on them, adding to the personalized feel of the product.

In order to get your custom supplements formulated, the company requires customers to fill out a basic health Rootine test. If possible they recommend sending in genetic data, like 23 and Me or a DNA test, and a blood test to best customize each supplement pack. The company has been featured on NBC and Forbes for its innovative technology and approach to the wellness industry.

rootine vitamin quiz

We have reviewed hundreds of different vitamins and supplements, and there is no doubt that Rootine is unique. The company’s offerings stand out in a crowded industry where it can be difficult to differentiate the value of all of the different products. The question is, are Rootine vitamins worth the money? Keep reading our in-depth Rootine vitamins review to find out.

Rootine Ingredients

Whenever we review a vitamin or supplement, we take a close look at the product’s formulation. In Rootine’s case, the formulation varies by customer, but we will still take a look at a few of the common ingredients in the blends. The idea behind Rootine Vitamins is that blood nutrient levels and DNA tests can help determine how the human body absorbs nutrients and what it needs for each individual.

In this section of our Rootine vitamins review, we will talk about the most important ingredients that are often in a basic multivitamin but also other nutrients that are not. 

If you are not interested in the details of each vitamin, feel free to skip this section and jump to our conclusion where we determine whether or not Rootine is worth paying for.



Phytosterols are often called plant sterols. To put it simply, phytosterols are the plant equivalent of animal cholesterol. There are many different types of phytosterols (sitosterol, campesterol, stigmasterol, etc.) When phytosterols are ingested, they compete for absorption with cholesterol. This is the reason phytosterols have often been recommended in the health and wellness industry as a natural way to lower LDL cholesterol.

Vitamin B6 (as pyridoxine HCl)

Vitamin B6 is a coenzyme involved in numerous metabolic pathways in the body. Most people tend to think of vitamin B6 as an energy booster. This is because vitamin B6, in its active form of pyridoxine-5-phosphate, is needed to help convert stored glycogen into glucose. If B6 is low then energy levels may also drop. This is one of the necessary vitamins for optimal health.

Additionally, pyridoxine is used in something called the methylation cycle. Without B6, levels of a substance called homocysteine may be elevated. This should be a cause for concern because high homocysteine is a risk factor for sudden cardiac death. There are a variety of genetic issues that cause low levels of B6 and even impair B6 metabolism.

Folate (as folic acid or methylfolate (5-MTHF))

Folate, similar to vitamin B6, is a coenzyme responsible for many different actions. Folate has become one of the more prominent vitamins on the market due to our understanding of genetics. Many people have what is called a single nucleotide polymorphism (SNP), which is a fancy way of saying a genetic mutation where one nucleic acid is switched for another one.

There are two different alterations that may occur. They are often referred to as C677T or A1298C. While one single base alteration out of approximately 3 billion bases may seem insignificant, it is not.  These genetic changes result in a dramatic reduction in the body’s ability to transform folic acid into its active 5-methyltetrahydrofolate (5-MTHF). People without the SNP process folic acid normally and there would be no need to use the much more costly 5-MTHF form. 

The fact Rootine indicates the use of folic acid, or 5-MTHF, indicates their understanding of these SNPs and brings credibility to their claim of customizing based on genetics. Folic acid gets a lot of attention for supporting cell replication and division. As a result, folic acid is vital throughout pregnancy. Additionally, those with folate deficiencies are at risk of elevated homocysteine and impaired neurotransmitter production. However, Rootine does not indicate its ingredient as USP certified.

Vitamin B12 (as methylcobalamin)

Vitamin B12 serves many roles similar to folate and vitamin B6. Vitamin B12 deficiencies are associated with a blood condition called anemia. Anemia occurs when the body is not producing enough red blood cells. Vitamin B12 often comes in one of two forms; cyanocobalamin and methylcobalamin.

Cyanocobalamin is the synthetic form of vitamin B12 and is only found in supplements. Methylcobalamin is widely regarded as the superior option and is the form Rootine vitamins include in their blends.

Vitamin B2 (as riboflavin)

Riboflavin is a very common vitamin supplement marketed to help with energy production. Riboflavin is required by the enzyme Methylenetetrahydrofolate reductase. This enzyme is responsible for the conversion of folate to its active form 5-MTHF. Riboflavin is often marketed to help with energy due to its role in oxygen utilization. It also aids in the breakdown of carbohydrates, proteins, and fats.

Magnesium (as magnesium hydroxide)

Magnesium has been credited as a critical cofactor in over 300 different enzymatic processes. More than 2/3rds of Americans are reported to be deficient in magnesium. Magnesium deficiencies often contribute to poor sleep, muscle spasms, headaches, and general irritability. Magnesium also plays a role in blood sugar control.

With Rootine, you will obtain the nutrient requirements for this mineral. While a quick blood test and lifestyle quiz could figure it out, taking a nutrient formula that has magnesium already is a good idea.  

Vitamin D3 (as cholecalciferol) 

Vitamin D is often thought of as the bone vitamin because it aids in calcium absorption from the gut. Still, vitamin D is responsible for regulating much more than calcium metabolism.

Low levels of vitamin D are often associated with fatigue, chronic pain, and a weak immune system. There are two forms of vitamin D. One is vitamin D2 which is often sold as a prescription at 50,000 IU. However, vitamin D3 is the more active form and is preferred by most physicians and pharmacists.

If you take the Rootine test or lifestyle quiz, you will probably get vitamin D3 suggested as part of your vitamins and minerals package. Although you could go with a recent blood test, almost all adults in North America are somewhat deficient in this vitamin.

Calcium (as calcium carbonate)

When people think of calcium they think of bones. Calcium is actually required for far more than just our bones. It is a principal molecule involved in regulating muscle contraction and cellular communication.

Calcium absorption is regulated with the help of vitamin D and its metabolism is regulated by vitamin K2.

Vitamin C (as ascorbic acid)

Everyone today knows when you are feeling sick, take vitamin C. This vitamin plays a large role in the immune system and fighting off infections.

Although you might need a customized dosage, many supplement companies include vitamin C because it is a powerful antioxidant as well. This vitamin is also a precursor to collagen production and helps with iron absorption in the body.

Vitamin E (as dl-alpha-tocopherol acetate)

Vitamin E was the first vitamin discovered back in 1922 and was originally called vitamine. This vitamin is beneficial for cognitive health, protection from free radicals, cellular processes, and more.

Zinc (as zinc citrate)

Zinc is another vital mineral that plays a large role in the immune system and protein synthesis. As mentioned previously, all-metal elements may come in a variety of forms that enhance absorption/activity. While zinc citrate is not the best form for absorption, it is also not the worst.

Manganese (as manganese sulphate)

Manganese is considered a trace mineral. We do not need as much manganese as other elements, like iron or magnesium. However, manganese is still important to the biological activity of growth, reproduction, and metabolism. A little goes a long way with manganese.

Copper (as copper sulphate)

Another trace mineral, copper is only needed in minute amounts. In fact, copper deficiency is often the result of too much zinc in the diet. The two elements compete for absorption through the same pathway.

Alpha Lipoic Acid

Often referred to as simply ALA, alpha-lipoic acid may help a variety of different health conditions. ALA is often recommended for those with diabetes and neuropathy. This is due to the fact ALA can help pull glucose out of the blood and bring it into the cell as well as reduce inflammation by targeting something called free radicals.

MSM (as methylsulfonylmethane)

MSM was once regarded as the best alternative treatment for joint pain, and it is often used by people with arthritis. Over the years the popularity of MSM has dipped because of the lack of scientific evidence supporting the claims.

However, MSM has started to gain interest again because of our new understanding of methylation. Not everyone may benefit from MSM but thanks to Rootine’s personalized supplements, the patients that may benefit from it will not need to worry about missing out.

CoQ10 (as coenzyme Q10)

Rootine includes CoQ10 in the form of ubiquinone. This ingredient is becoming increasingly popular as new research comes out showing the importance of this antioxidant.

Iron (as iron bisglycinate)

Iron is required to ensure the transportation of oxygen throughout the body. It is makes up a protein called hemoglobin. Women are at a higher risk of iron deficiency due to their menstrual cycle. Genetics and blood work will clearly indicate if a person needs iron.

Selenium (as sodium selenite / selenomethionene)

Selenium is a trace mineral that many people lack in their diets. This mineral is required to maintain thyroid function and inflammatory balance.

One Brazil nut is enough to provide more than enough selenium for a person each day. Selenomethionine tends to be the preferred option by integrative/function medicine practitioners.

Rootine Vitamins Ingredients

Ingredient Quality

Dr. Daniel Wallerstorfer (PhD.) is the person in charge of Rootine’s ingredient sourcing. Ingredients are subject to rigorous testing for quality, purity, and contamination. The company also subjects its products to third-party lab testing, which is always a good sign.

Rootine Benefits

If you are reading this Rootine vitamins review, you are probably already sold on the importance of taking vitamins. Vitamins can help fill in the gaps in your diet and improve your overall health. For the sake of this review, we will not reiterate all of the benefits of taking vitamins in general. Instead, we will look at the unique benefits of Rootine specifically.

Individual Specificity

Most multivitamins are designed to be a “one-size-fits-all” solution for people who are looking to improve their health. Some companies offer specialized multivitamins for men and women of different ages (i.e., Men’s Daily 55+). Rootine takes this approach a step further by offering a multivitamin that is designed specifically for you.

This approach is built off the premise that we are all unique as individuals. We all have different genetics, lifestyles, diets, and so on.

Rootine operates under the “Test, Take, Track” methodology. First, they offer a few testing options that help them understand your personal needs. You can take a DNA test, a blood test, an online questionnaire, or a combination of all three.

From there, Rootine will formulate a blend of vitamins designed specifically for you, creating a DNA-based vitamin package. You can take the vitamins daily and track your progress in an online dashboard (if you take more blood tests).

This unique process is really what sets Rootine apart. Taking a multivitamin is generally a passive activity. You take your multivitamin with a meal and do not think much of it.

Rootine takes a more active approach to this process, with a focus on effectiveness. Instead of taking just any vitamin and hoping for the best, you get a customized multivitamin and the tools you need to track the results.

Enhanced Nutrient Absorption

Rootine aims to be one of the most effective multivitamin solutions on the market. One issue with many multivitamins is they are difficult for the body to absorb. Ingesting a lot of healthy vitamins and nutrients is useless if your body cannot absorb them.

Rootine uses a unique microbead delivery system to increase nutrient absorption.

They claim their research indicates microbeads enhance absorption in the gut by decreasing competition between the vitamins and minerals.

Additionally, the microbead technology produces a time-release effect of vitamins and minerals. Rootine’s website states absorption takes place over 12+ hours.  

Rootine Vitamins

Does Rootine Work?

Now that we looked at all of the common ingredients and benefits of Rootine, it is time to answer the question you probably came to this Rootine review looking for. Does Rootine work?

Rootine is arguably one of the more effective multivitamins on the market. The company takes a personalized approach to its formulation, utilizes high-quality ingredients, and provides a delivery system designed for maximum nutrient absorption.

It is safe to say that Rootine is an effective multivitamin, and likely more effective than most multivitamins you will find on the shelves of a health store. The next question is – is it worth the money?

We also like the fact that there seem to be no side effects. Some people suggest that there might be intolerance to the slow release microbeads. All in all, these are much easier to take than having trouble swallowing large multivitamins. 

Is Rootine Worth the Money?

By this point, it should be clear that Rootine has taken a unique approach to revolutionizing the multivitamin industry. The product takes an intelligent approach to supplementation and offers high-quality ingredients in custom formulations. Simply put, it is a multivitamin that is better than most.

Of course, price is a factor as well.

rootine dna and blood test

Rootine can only be purchased from the company’s official website. There are three main offerings:

  1. The Personalized Vitamins – $69 for a three-month supply
  2. The DNA Test – $125
  3. The Blood Vitamin Test – $99

There is no doubt that Rootine is one of the more expensive multivitamin solutions on the market. While the product is not cheap in the multivitamin category, it is not exorbitantly priced either (for what you get).

Rootine Nutrition

What Makes Rootine Special 

Let us break things down further to determine whether or not you will get value out of Rootine.

First off, we highly recommend taking the DNA Test and Blood Vitamin Test if you want to get the most value out of Rootine. After all – that is the pitch. You get a customized multivitamin solution based on your biochemistry. If you skip the test, you are missing out on a big part of the product offering.

If you have already taken a DNA test from 23andMe or AncestryDNA, you can upload those results and save the $125 you would spend on a Rootine DNA Test. If you have never taken a DNA test before, expect to spend about $225 on testing to get set up with Rootine (for both the DNA and blood test).

Once you are tested, the only expense is the multivitamins, which are $69 for a three-month supply. This comes down to about $23 per month and we were actually impressed with this price point. This is surprisingly cost-effective for a high-end multivitamin.

Sure, you can find cheaper options, BUT the price is not the only factor to consider. A $10 multivitamin that is ineffective is worthless and a $23 multivitamin that works is a great value.

We were happy with the pricing for Rootine’s multivitamin packets.

The last consideration is retesting. You can take new blood tests in the future to track your results. These tests will run $99 per test and should be taken a few months after starting your Rootine regimen. While these tests certainly add to the value of the service, you can skip them if you prefer not to spend the extra money.

Overall, Rootine is ideal for individuals who are serious about health and supplementation. If you are a casual multivitamin user who picks up the occasional bottle from the grocery store shelf, takes it for a few days, and then repeats the process a few months later, it will be difficult to justify the cost.

If you are serious about health and supplementation and you are looking for a highly effective option, Rootine is definitely worth a shot. The product becomes more cost-effective after the initial testing and the product quality definitely justifies the price point.

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Where to Buy Rootine Personal Vitamins

Rootine can only be bought off the official company website here. You can choose to get a Rootine subscription and receive your vitamins every month. You can also cancel quickly whenever you want. However, because these vitamins are personalized using blood panel results and lifestyle data, you are not able to return them for a refund. 

Rootine Vitamins Review: Final Thoughts 

If you are all in for your health, whether that is precision nutrition, gut health, and a vitamin company that cares, then Rootine is for you. Taking a DNA test and using detailed biological data gives this vitamin company an advantage. We also like that Rootine uses high-grade

nutrients in safe and effective doses. Your daily vitamins are really a custom multivitamin that fits your specific diet and will help you thrive. Although the cost is high, the benefits are also more than other companies. We recommend you try it out at least once if you are serious about your health. If it is not for you, canceling is just one click away.

Overall Rating:
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Juliana Tamayo, MS, Nutritionist

Juliana Tamayo is a registered dietitian with a Master of Science in Nutrition, Dietetics, and Sensory Sciences from the Kansas State University. She also has a B.A in Journalism and Creative writing, and lives in Washington, D.C. where she works as a part-time writer and editor and clinical dietitian. Juliana has experience covering all sorts of health and nutrition topics, including chronic illnesses, medicine, cooking, fitness, alternative healing, and more.