Last Updated: Sep 17, 2020

Nucific BIO-X4 Review – Does This Supplement Really Work?

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Nucific BIO-X4 is a supplement that is designed to promote weight management and smoother digestion. The supplement is named “BIO-X4” after its four key benefits. BIO-X4 is designed to help you manage cravings, lose weight, improve your digestion, and boost your metabolism. The product contains a blend of probiotics, digestive enzymes, and weight management ingredients.

The product live up to the hype? Read our full Nucific BIO-X4 review to find out.

About Nucific

BIO-X4 is created by a company called Nucific. The main face behind Nucific is Dr. Amy Lee.

Dr. Amy Lee is certified by the American Board of Internal Medicine. She is also a member of the National Board of Physician Nutrition Specialists and the American Board of Obesity Medicine.

Dr. Amy Lee is also the chief medical officer at the Lindora Clinic, a weight loss and wellness clinic with multiple locations across California. Dr. Lee has treated over 15,000 patients and is well-credentialed as a weight loss specialist.

Dr. Amy Lee of Nucific

Nucific, backed by Dr. Amy Lee, aims to create cutting-edge supplements that are backed by science. The company has a small line of well-researched supplements, many of which relate to gut health.

Let’s take a closer look at the subject of today’s review: BIO-X4.

What is Bio-X4?

BIO-X4 is a 4-in-1 weight management supplement and probiotic. The product is positioned as a blend of four different digestive and fat-loss ingredients that are designed to support weight management and healthy digestion. The formulation contains different probiotic blends, consisting of a total of seven probiotic strains, three different digestive enzymes in a proprietary blend, and two weight management ingredients, Green Tea and Slimaluma. 

Slimaluma is a trademarked Caralluma Fimbriata extract which is used an appetite suppressant. The Green Tea is included for energy and the fat-burning capabilities of EGCG.  The concept is that these two weight management products work in concert with the digestive enhancers, probiotics, and digestive enzymes, to help your body reach its full weight-loss potential. 

Nucific Bio-X4

Let’s take a closer look at the ingredients.

Bio-X4 Key Ingredients

Many of the ingredients in Bio-X4 have been proven to be effective. These ingredients are all popular in the world of weight loss and digestion supplements. This review will explore the combination of the three compounds and the amount of each ingredient. 

Here is the official ingredient list:

  • Probiotics (4 billion CFU – Colony Forming Units) per capsule
    • Lactobacillus Blend: L-acidophilus, L-rhamnosus, and L-plantorum.
    • Bifidobacterum Blend: B-lactis and B-animalis.
  • Digestive Enzyme Blend (43 mg.): Amylase, Bromelain, and Lipase. 
  • Weight Management Blend (100 mg): Green Tea Extract (50% EGCG).
  • Craving Control Blend (166 mg): Slimaluma™ (Caralluma Fimbriata extract)

BIO-X4 offers transparent labeling and does not hide the ingredient doses behind a proprietary blend.

Bio-X4 Ingredients

Here’s a quick breakdown of what each of the ingredients does:

The probiotic blend is designed to promote smoother digestion and improve overall gut health. Probiotic supplementation is becoming increasingly popular as scientists uncover more information on how important gut health is. Gut health has an impact on more than just digestion. It can also impact inflammation, energy levels, and immune health. While BIO-X4 is not marketed as a standalone probiotic supplement, it contains 4 billion CFUs of the most popular strains of probiotics and can deliver many of the benefits you’d expect from probiotics.

BIO-X4 also contains a digestive enzyme blend. Like probiotics, this blend is designed to improve digestive health. Digestive enzymes can help your body break down food more efficiently and get more nutrients out of the food you eat. This blend will be particularly beneficial for users who have noticeable stomach issues. Many people take digestive enzymes to improve digestion and avoid stomach discomfort.

Green Tea Extract is included to promote weight management. This is the sole ingredient included in the weight management blend, and for good reason. Green Tea Extract contains a natural compound called EGCG which can help you boost your metabolism and aid in weight loss. Some users also report that it increases their energy. While Green Tea Extract will not magically burn fat, it does improve your metabolism and it can help support your weight loss efforts when combined with a proper diet and exercise routine. It is also one of the safer, all-natural ingredients that can be included in a weight loss supplement. 

Lastly, BIO-X4 contains an ingredient called Slimaluma (caralluma fimbriata). Caralluma fimbriata is the sole ingredient in the craving control blend. Caralluma fimbriata us a plant-based ingredient and Slimaluma is the patented version of the plant’s extract. Slimaluma is an ingredient used in many excellent diet products. This ingredient is designed to help users control their unhealthy food cravings. While the green tea extract can help improve your metabolism, the Slimaluma can help you avoid some of the cravings that lead you to eat foods that make you gain weight.

These ingredients work well together to create an “all-in-one” weight loss supplement that promotes healthy weight loss and improved gut health.

Bio-X4 Dosages

The suggested use is one capsule with each meal (three times per day). The label claims you can take up to two capsules per meal, but you should not exceed six capsules per day.

Benefits of Bio-X4

BIO-X4 is designed to support four key areas of digestive health. These include:

  • Reduced appetite – eliminates junk food cravings
  • Fat Burning 
  • Significantly more energy throughout the day
  • Freedom from embarrassing gas, bloating, and irregular bathroom visits

Essentially, BIO-X4 is a supplement designed for people who want to manage all digestive issues with a single supplement. The product is designed to help you reduce cravings, boost your metabolism, and improve your digestion. The end result is a healthier gut and better weight regulation.

One thing we really like about Nucific Bio-X4 is that it focuses on healthy weight loss. Many fat burners are loaded up with stimulants and sketchy ingredients that may have negative side effects. Bio-X4 is designed to help you lose weight in a safe and healthy way.

We wouldn’t even classify Bio-X4 as just a weight loss supplement. As implied by the name, Bio-X4 offers four distinct benefits. It acts as a probiotic supplement that can improve your gut health, it offers a craving control blend that can help you decrease your calorie intake,  it offers digestive enzymes that can improve your digestion, and it offers a weight management blend that can help you shed unwanted pounds.

Bio-X4 Benefits

Who Needs Bio-X4?

BIO-X4 can be helpful to anyone who is trying to slim down naturally without dangerous prescription drugs, radical lifestyle changes, and without impossible-to-maintain diets. For maximum efficacy, Nucific advocates a healthy diet and regular exercise. Those who adhere to this regimen should see results in the first 60 days.

Bio-X4 can also be used by individuals who are looking to improve their digestive health. The probiotics and enzymes can promote smoother digestion, and the green tea extract can boost your metabolism.

Does Bio-X4 Really Work?

With its two potent weight management ingredients, Green Tea Extract and the patented, trademarked Slimaluma, there is every reason to believe the product will perform. There are a plethora of positive Bio-X4 reviews from people who have used the product. The product also passed our review process.

If consumers follow the advice on Nucific’s site, regarding a healthy diet and a balanced exercise regimen when using Bio-X4, there is every reason to believe they will have a positive experience.

Bio-X4 Reviews

If you are considering using Nucific BIO-X4, make sure you have realistic expectations. The supplement contains ingredients that are proven to improve your gut health, boost your metabolism, and help you avoid unwanted food cravings. That said, there is no such thing as a “miracle” supplement that melts away body fat. BIO-X4 is most effective when combined with a healthy diet and a regular exercise routine.

If you are considering buying Bio-X4, you should also consider the digestive benefits. This supplement is not designed just for weight loss. It is also intended to improve your gut health and support smoother digestion. If you are going to pay for a product like Bio-X4, you will get the most value out of it if you are interested in more than just weight loss.

Potential Side Effects of Bio-X4

The potential side effects cited from Bio-X4 are minor; excessive intestinal gas, bloating, minor cramps in the abdominal region, nausea, or constipation, which should subside after a week of use.

These side effects are associated with any type of digestive supplement and not exclusive to Nucific Bio-X4. Bio-X4 contains all-natural ingredients that are well-researched. Side effects should be rare, but you should consult with your physician if you think you may have sensitivities to any of the ingredients in this formula.

Where to Buy Bio-X4

The best place to buy BIO-X4 is on the company’s official website. Each bottle of Nucific contains 90 capsules, which can last anywhere from 30-90 days (depending on how many capsules you take daily).

BIO-X4 Pricing

Each bottle is available for $99, however you can use this link to save 50% and get your first bottle for $49. Further discounts are available when you purchase multiple bottles in advance. You can buy three bottles for $129 ($43/bottle) or six bottles for $240 ($40/bottle). We recommend starting with a single bottle to see if the product works well for you. If it does, it definitely makes sense to save money by ordering a few bottles at a time.

Every order comes with free shipping and is backed by a 90-day money-back guarantee. The 90-day money-back guarantee states that customers can get a full refund if they send the product back within 90 days of purchasing it. You can even get your money back if you have used the entire bottle.

We are always impressed when supplement companies back their products with a money-back guarantee because it means they truly believe in the product. It also means that customers have no financial risk – if they don’t like it, they can send it back for a refund.

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Bio X4 FAQ

We have received a few additional questions about Bio-X4 since our initial review. Here are the answers to the most common questions.

Is Bio-X4 safe to take?

Overall, Bio-X4 is safe to take. The ingredients do not generally have side effects and, when they do, the side effects are usually mild (i.e. stomach discomfort). 

Does Bio-X4 help you lose weight?

Yes, Bio-X4 helps you lose weight. The keyword here is, “help.” If you want to lose weight, you still need to put in the work. Bio-X4 can’t do all of the heavy lifting for you. 

If you combine Bio-X4 with a healthy diet and fitness routine, it can help you shed unwanted pounds.

How often do you take Bio-X4?

Nucific recommends that you take one capsule with each meal for up 3 meals per day. The company mentions that you can increase the dosage to two capsules, but you’re probably better off with one (assuming it is effective for you). Taking two capsules means you will run out of your supply twice as fast (making the product twice as expensive). If you really want to conserve your supply, you could limit your Bio-X4 intake to 1-2 times/day. You may want to experiment with different timing/dosages to see what works best for you.

How Does Bio-X4 compare to other supplements?

Bio-X4 is unique in that it blends ingredients with a broad range of benefits. It is not a standalone probiotic supplement, digestive supplement, or weight loss supplement. It is a combination of all three. While the product is a bit expensive, it offers a broad range of benefits and may be able to replace some of the current supplements you already take. You can also use this link to save 50% on your first purchase to see if the product is effective for you.

It’s hard to compare Bio-X4 to other supplements since the formulation is unique. You can find standalone supplements that contain probiotics, digestive enzymes, Slimaluma, and green tea extract, but we’ve yet to come across a product that combines all of them. 

Bio-X4 scored highly in our review (higher than many competing supplements) and the Bio-X4 reviews from customers are overwhelmingly positive. When it comes to weight loss products, these types of reviews are no easy feat. 

In Summary

BIO X4 contains several verifiably beneficial ingredients for digestive support, appetite suppressant, energy, and fat burn. The product is all-natural and contains well-researched ingredients with little-to-no side effects.

We were impressed with what we uncovered in our BIOX4 review and it seems that customer reviews of BIO-X4 are just as favorable. If you are looking for a supplement that can improve your digestive health and help you lose weight, Bio-X4 may be worth a shot.

Every order is backed by a 90-day money-back guarantee, so you have little risk in trying it.

Nucific BIO-X4 Review
  • Efficacy
  • Value


Bio-X4 by Nucific is a 4-in-1 weight management supplement and probiotic that claims to help manage weight. Does this product do what it says? Is Bio-X4 by Nucific a scam? Read our review to learn the answers to these questions and more.

Disclosure: Some of the links in our articles are from our advertisers. Learn more about how we make money.

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