Nucific BIO-X4 Review – Does This Supplement Really Work?

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By Leslie Waterson

Reviewed by Juliana Tamayo, MS, RDN - Last Updated


What if you could obtain multiple health benefits from one supplement? Wouldn’t it be nice to take a supplement that improved your digestion, helped you manage your weight, and helped you avoid food cravings throughout the day? That’s exactly what Nucific Bio-X4 claims to assist with.

Nucific BIO-X4 is a supplement that is designed to promote weight management and smoother digestion. The product contains a blend of probiotics, digestive enzymes, and weight management ingredients.

Does this dietary supplement live up to the hype? Read our full Nucific BIO-X4 review to find out!

Nucific BIO-X4 Review: Key Facts

BenefitsImproves Digestive Health, Promotes Weight Loss, Boosts Metabolism
IngredientsProbiotics, Digestive Enzymes, Green Tea, and more
DiscountsUp to 60% Off

About Nucific

Nucific is the company behind the BIO-X4 supplement. The main face behind this organization is Dr. Amy Lee.

Dr. Lee is certified by the American Board of Internal Medicine. She is also a member of the National Board of Physician Nutrition Specialists and the American Board of Obesity Medicine.

Also, Dr. Amy Lee is the chief medical officer at the Lindora Clinic, a weight loss and wellness clinic with multiple locations across California. In fact, she has treated over 15,000 patients and is well-credentialed as a weight loss specialist.


Nucific aims to create cutting-edge supplements that are backed by science. The company has a small line of well-researched supplements, many of which relate to gut health.

What is Nucific Bio-X4?

BIO-X4 is a 4-in-1 weight management supplement and probiotic. The supplement is named “BIO-X4” after its four key health benefits.

Unlike other nutritional supplements, this one helps you manage cravings, can promote weight loss, improves your digestive system health, and may even boost your metabolism.

The product is positioned as a blend of four different digestive and fat-loss ingredients that are there to aid weight loss and protect your digestive system.

The formulation contains different probiotic blends, consisting of a total of seven probiotic strains, three different digestive enzymes in a proprietary blend, and two weight management ingredients, Green Tea and Slimaluma. 

Nucific BIO-X4

Let’s take a closer look at the ingredients.

Bio-X4 Key Ingredients

Many of the ingredients in Bio-X4 are scientifically effective. These are all popular in the world of weight loss and digestion supplements.

In this review, we will explore the combination of the three compounds and the amount of each ingredient. 

Here is the official ingredient list:

  • Probiotics (4 billion CFU – Colony Forming Units) per capsule
    • Lactobacillus Blend: Lactobacillus acidophilus, L-rhamnosus, and L-plantorum.
    • Bifidobacterum Blend: B-lactis and B-animalis.
  • Digestive Enzyme Blend (43 mg.): Amylase, Bromelain, and Lipase. 
  • Weight Management Blend (100 mg): Green Tea Extract (50% EGCG).
  • Craving Control Blend (166 mg): Slimaluma™ (Caralluma Fimbriata extract)
Bio-X4 Ingredients

BIO-X4 offers transparent labeling and does not hide the ingredient doses behind a proprietary blend.

Below is a quick breakdown of what each of the ingredients does:

Probiotic Blend

This blend is for improving digestion. Probiotic supplements are becoming increasingly popular as scientists uncover more information on how important gut health is. Probiotics are beneficial to gut bacteria backed by scientific evidence to promote better digestion. They may also help treat health issues such as short bowel syndrome, stomach pain, and irritable bowel syndrome.

Your digestive system has an impact on more than just digestion. It also impacts inflammation, energy levels, and immune health. When things are not balanced, you may notice you gain more weight, have high blood pressure, and feel more fatigue.

While BIO-X4 is not marketed as a standalone probiotic supplement, it contains 4 billion CFUs of the most popular strains of probiotics, such as lactobacillus acidophilus. Evidently, it can deliver many of the other benefits you get from taking supplements with probiotics.

Digestive Enzymes Blend

BIO-X4 also contains a blend designed to support your body’s digestive processes. The main ingredients in this blend are Amylase and Lipase. These are two digestive enzymes that in healthy people work to digest macronutrients effectively.

However, in certain cases, like pancreatic insufficiency, individuals may need enzyme medications. With this blend, everyone will begin to see improvements in how they digest and absorb nutrients.

Digestive enzymes can help your body break down food more efficiently and get more nutrients out of the food you eat. Taking this blend saves you some trouble without making any dietary changes and without adding more health products to your diet.

Green Tea Extract

The green tea extract is included in this weight management blend because it contains a natural compound called EGCG that can help you boost your metabolism and aid in weight loss.

Some users also report that it increases their energy, aside from the weight loss aspect it brings. While Green Tea Extract will not magically burn fat, it does improve your metabolism. In overweight and obese individuals, changing your diet, exercising, and having a healthier lifestyle will make the effects more noticeable.

This blend is also one of the safer, all-natural ingredients that can be included in a weight loss supplement that also happens to boost metabolism and helps reduce appetite. Some individuals have also reported a shrink in their waist circumference after taking this supplement.

Overall, the concept is that green tea extract and Stimaluma work in concert with the digestive enhancers, probiotics, and digestive enzymes, to help your body reach full weight loss effects. 


This ingredient is a trademark of the Caralluma Fimbriata extract, which is used as an appetite suppressant. 

Overall, this is the sole ingredient in the craving control blend. Caralluma fimbriata is a plant-based ingredient and Slimaluma is the patented version. Furthermore, it is an ingredient present in many diet products.

The reasoning behind Slimaluma is to curb cravings. While the green tea extract can help improve your metabolism, the Slimaluma can help you avoid some of the cravings that lead you to eat foods that make you gain weight.

Even more, unhealthy cravings may kill off some of the beneficial gut bacteria you need, so Stimaluma acts both ways by boosting the probiotic strains in the product.

Nucific BIO-X4 Pill Capsules

Benefits of Bio-X4

BIO-X4 is designed to support four key areas of digestive health. These include:

  • Reduced appetite – eliminates junk food cravings
  • Fat Burning 
  • Significantly more energy throughout the day
  • Freedom from embarrassing gas, bloating, and irregular bathroom visits

Essentially, BIO-X4 is a supplement designed for people who want to manage digestive issues with a single supplement. The product helps you reduce cravings, boost your metabolism, and improve your digestion. In the end, you will have a healthier gut and better weight regulation all thanks to active ingredients that happen to be natural.

One thing we like about Nucific Bio-X4 is that it focuses on healthy weight loss. Many fat burners are loaded up with stimulants and sketchy ingredients that may have negative side effects. Bio-X4 will help you lose weight safely and healthily.

We wouldn’t even classify Bio-X4 as just a weight loss supplement. As implied by the name, Bio-X4 offers four distinct benefits.

In fact, it offers a craving control blend that can help you decrease your caloric intake,  it offers digestive enzymes and probiotics that can improve your digestion, and it offers a weight control blend that can help you shed unwanted pounds.

Nucific BIO-X4 Label

Who Needs Bio-X4?

BIO-X4 can be helpful to anyone who is trying to slim down naturally without dangerous prescription drugs, radical lifestyle changes, and impossible-to-maintain diets.

For maximum efficacy, Nucific advocates a healthy diet and regular exercise. Those who adhere to this regimen should see positive results in the first 60 days.

Bio-X4 can also be used by individuals who are looking to improve their digestive health. The probiotics and enzymes can promote smoother digestion, and the green tea extract can boost your metabolism.

Bio-X4 Dosages

The suggested use is one capsule with each meal (three times per day). The label claims you can take up to two capsules per meal, but you should not exceed six capsules per day.

Does Bio-X4 Really Work For Weight Loss?

With its two potent weight control ingredients, Green Tea Extract, and the patented, trademarked Slimaluma, there is every reason to believe the product will perform. There is also some scientific evidence that it is safe and successful at some level for weight loss.

The weight-loss claims, may not be just claims. There are a plethora of positive Bio-X4 reviews from people who have used the product, and Bio-X4 also passed our review process.

If consumers follow the advice on Nucific’s site regarding a healthy diet and a balanced exercise regimen when using Bio-X4, there is every reason to believe they will have a positive experience.

Bio-X4 Reviews

Weight Loss: The Bottom Line

If you are considering using Nucific BIO-X4, make sure you have realistic expectations.

The supplement contains ingredients that are proven to improve your gut health, boost your metabolism, and help you avoid unwanted food cravings.

That said, there is no such thing as a “miracle” supplement that melts away body fat. BIO-X4 is most effective when combined with a healthy diet and a regular exercise routine.

If you are considering buying Bio-X4, you should also consider the digestive benefits. This supplement is not just for weight loss. It is also going to improve your gut health and support smoother digestion.

On the other hand, you are going to pay for a product like Bio-X4, you will get the most value out of it if you care about more than just weight loss.

Nucific BIO-X4 Supplement

Is Bio-X4 Safe?

The potential side effects cited from Bio-X4 are minor; excessive intestinal gas, bloating, minor cramps in the abdominal region, nausea, or constipation, which should subside after a week of use.

These side effects are associated with any type of digestive supplement and not exclusive to Nucific Bio-X4.

Keep in mind too that this supplement is allergen-free, gluten-free, lactose-free, contains no synthetic fillers, and no food coloring.

Side effects should be rare, but you should consult with your physician if you think you may have sensitivities to any of the ingredients in this formula.

If you tend to have a severe allergic reaction or have any allergy concerns, always check with your doctor before you start a supplement.

Where to Buy Bio-X4

The best place to buy BIO-X4 is on the company’s official website. Each bottle of Nucific contains 90 capsules, which can last anywhere from 30-90 days depending on what regimen you are using.

Nucific BIO-X4 Website

Each bottle is available for $99, however you can use this link to save 50% and get your first bottle for $49. Package deals are available when you purchase multiple bottles in advance. You can buy three bottles for $129 ($43/bottle) or six bottles for $240 ($40/bottle).

We recommend starting with a single bottle to see if the product works well for you during those early stages. If it does, it definitely makes sense to save money by ordering a few bottles at a time.

Every order comes with free shipping and a 90-day money-back guarantee, so you can get a full refund if they send the product back within 90 days of purchasing it.

As a bonus, you can even get your money back if you have used the entire bottle.

We are always happy when supplement companies back their products with a money-back guarantee because it means they truly believe in their product.

Another fun fact, the product comes in eco-friendly packaging that will give you peace of mind too.

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Bio-X4 FAQ

We have received a few additional questions about Bio-X4 since our initial review. Here are the answers to the most common questions.

Is Bio-X4 safe to take?

Overall, Bio-X4 is safe to take. The ingredients do not generally have side effects and, when they do, the side effects are usually mild (i.e. stomach discomfort). 

While the Food and Drug Administration does not regulate supplements, the company has an FDA disclaimer that is clear about that.

Also, the Caralluma fimbriata in Slimaluma is on the FDA generally recognized as a safe (GRAS) food list.

Does Bio-X4 help you lose weight?

Yes, Bio-X4 helps you lose weight. The keyword here is “help.” If you want to lose weight, you still need to put in the work. Bio-X4 will not do all of the heavy lifting for you. 

If you combine Bio-X4 with a healthy diet and fitness routine, it can help you shed unwanted pounds.

How does Bio-X4 compare to other supplements?

Bio-X4 is unique in that it blends ingredients with a broad range of benefits. It is not a standalone probiotic supplement, digestive supplement, or weight loss supplement.

While the product is a bit expensive, it offers a broad range of benefits and may be able to replace some of the current supplements you already take. You can also use this link to save 50% on your first purchase to see if the product is effective for you.

It is hard to compare Bio-X4 to other supplements since the formulation is unique. You can find standalone supplements that contain probiotics, digestive enzymes, Slimaluma, and green tea extract, but we have yet to come across a product that combines all of them. 

Bio-X4 scored highly in our review (higher than many competing supplements) and the Bio-X4 reviews from customers are overwhelmingly positive. When it comes to weight loss products, these types of reviews are no easy feat. 

Nucific BIO-X4 Review: In Summary

BIO X4 contains several verifiably beneficial ingredients for digestive support, appetite suppressant, energy, and fat burn all in one capsule. The product is all-natural and contains well-researched ingredients with little-to-no side effects.

We were impressed with what we uncovered in our BIOX4 review and it seems that customer reviews of BIO-X4 are just as favorable.

If you are looking for a supplement that can improve your digestive health and help you lose weight, Bio-X4 may be worth a shot.

Every order you make comes with a 90-day money-back guarantee, so you have little risk in trying it.

Start with one capsule and take it slowly, remember that a huge difference will not be noticeable immediately. When you follow a healthy diet, sleep better, and are more active, this product will help your overall health.

Overall Rating:
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Leslie Waterson

Leslie has been passionately involved in the health and fitness industries for over a decade. She is constantly reviewing the latest scientific research and studies in order to take a research-backed approach to lifestyle optimization. Her main areas of interest include nutrition and supplementation. Leslie shares her findings on Fitness Clone to help other health enthusiasts choose the products and routines that will help them achieve their goals.